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Tongue sole (Cynoglossus semilaevis) interleukin 10 plays a negative role in the immune response against bacterial infection
Li, Xue-peng1,2; Jiang, Shuai1,2; Sun, Bin1,2,3; Zhang, Jian1,2
2019-12-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume95Pages:93-104
Corresponding AuthorLi, Xue-peng(lixuepeng14@mails.ucas.ac.cn) ; Zhang, Jian(zhangjian@qdio.ac.cn)
AbstractInterleukin-10 (IL-10) is a pleiotropic cytokine and plays a crucial role in immunity. In the current study, we examined the expression patterns and biological functions of tongue sole Cynogiossus semilaevis IL-10 (CsIL-10). CsIL-10 is composed of 186 amino acid residues and shares 46.3%-71.7% identities with other teleost IL-10. Csil-10 expression occurred in multiple tissues and was regulated by bacterial infection. Recombinant CsIL-10 (rCsIL-10) in the form of a dimer bound to a wide range of bacterial species but did not affect bacterial growth. rCsIL-10 could interact with peripheral blood leukocytes (PBL) and significantly reduce the phagocytic activity, ROS production, and apoptosis of PBL. When injected in vivo, rCsIL-10 significantly suppressed the expression of proinflammatory cytokines and promoted bacterial dissemination in tongue sole tissues. Consistently, knock-down of Csil-10 significantly inhibited bacterial infection in tongue sole. Taken together, these results indicate that CsIL-10 plays a negative regulatory role in the immune response against bacterial infection.
KeywordInterleukin-10 Cynoglossus semilaevis Peripheral blood leukocytes Immune defense Bacterial infection
DOI10.1016/j.fsi.2019.10.023
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31802329] ; Shandong Major Science and Technology Innovation Project[2018SDKJ0302-2] ; China Postdoctoral Science Foundation[2018M632733] ; Taishan Scholar Program of Shandong Province
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000503099200008
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/164143
Collection实验海洋生物学重点实验室
Corresponding AuthorLi, Xue-peng; Zhang, Jian
Affiliation1.Chinese Acad Sci, CAS Ctr Ocean Megasci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Xue-peng,Jiang, Shuai,Sun, Bin,et al. Tongue sole (Cynoglossus semilaevis) interleukin 10 plays a negative role in the immune response against bacterial infection[J]. FISH & SHELLFISH IMMUNOLOGY,2019,95:93-104.
APA Li, Xue-peng,Jiang, Shuai,Sun, Bin,&Zhang, Jian.(2019).Tongue sole (Cynoglossus semilaevis) interleukin 10 plays a negative role in the immune response against bacterial infection.FISH & SHELLFISH IMMUNOLOGY,95,93-104.
MLA Li, Xue-peng,et al."Tongue sole (Cynoglossus semilaevis) interleukin 10 plays a negative role in the immune response against bacterial infection".FISH & SHELLFISH IMMUNOLOGY 95(2019):93-104.
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