IOCAS-IR  > 海洋环境腐蚀与与生物污损重点实验室
pH-responsive linkages-enabled layer-by-layer assembled antibacterial and antiadhesive multilayer films with polyelectrolyte nanocapsules as biocide delivery vehicles
Cai, Haoyuan1,2,3,4; Wang, Peng1,3,4; Zhang, Dun1,3,4
2019-12-01
Source PublicationJOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
ISSN1773-2247
Volume54Pages:15
Corresponding AuthorWang, Peng(wangpeng@qdio.ac.cn) ; Zhang, Dun(zhangdun@qdio.ac.cn)
AbstractApplication of the polymer capsules as vehicles for antibacterial surface against bacterial infections is restricted by spontaneous leakage and specifically responsive release of antibacterial agents. Herein, we present the integration of pH-responsive nanocapsules as delivery tools for hydrophobic biocide within layer-by-layer (LbL) films utilizing alternating imine linkages as the driving force for assembly, thus enabling the introduction of drug and controlled release. The novel capsules are fabricated by means of electrostatic LbL assembly, namely, tannin acid/chitosan nanocapsules embedded with triclosan@cetyltrimethylammonium bromide micelles (TCS@CTAB/TA/CH). The nanocapsules achieve an excellent pH-responsive activity that the release efficiency of antibacterial agent triclosan (TCS) increases by nearly 61.8% from pH 8 to 4. Subsequently, the smart nanocapsules are alternatively incorporated via imine linkage into the dextran aldehyde (DA) polyelectrolyte multilayers in LbL deposition (denoted as (DA-TCS@CTAB/TA/CH)(n) films). The as-prepared samples are characterized by FTIR, FESEM, TEM, DLS and AFM. Noticeably, the (DA-TCS @CTAB/TA/CH)(20.5) film exhibites optimal pH-responsive activity with release concentration of TCS up to 4.01 mg/L at pH 6. The bacteriostatic percentages of (DA-TCS@CTAB/TA/CH)(20.5) against E. coll. and P. aeruginosa are respectively 99.62% and 97.35% after 24-h incubation at pH 6. Besides, the multilayers are capable of supplying a long-term (30 days) antibacterial property. The self-polishing mechanism of (DA-TCS@CTAB/TA/CH)(n) films is proposed to illuminate the enhanced antibacterial and antiadhesive performances. It seems that the films present a promising way to incorporate biocide to resist bacterial infections and prolong the antimicrobial activity of antibacterial surface.
KeywordAntibacterial pH-responsive Layer-by-layer Self-polishing Antiadhesive
DOI10.1016/j.jddst.2019.101251
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[41576079] ; National Natural Science Foundation of China[41922040] ; Qingdao National Laboratory for Marine Science and Technology[2017ASTCP-ES02] ; AoShan Talent Program
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000505159500080
PublisherELSEVIER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/164107
Collection海洋环境腐蚀与与生物污损重点实验室
Corresponding AuthorWang, Peng; Zhang, Dun
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Environm Corros & Biofouling, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China
2.Univ Chinese Acad Sci, 19 Jia Yuquan Rd, Beijing 100039, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Open Studio Marine Corros & Protect, 1 Wenhai Rd, Qingdao 266237, Shandong, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Cai, Haoyuan,Wang, Peng,Zhang, Dun. pH-responsive linkages-enabled layer-by-layer assembled antibacterial and antiadhesive multilayer films with polyelectrolyte nanocapsules as biocide delivery vehicles[J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,2019,54:15.
APA Cai, Haoyuan,Wang, Peng,&Zhang, Dun.(2019).pH-responsive linkages-enabled layer-by-layer assembled antibacterial and antiadhesive multilayer films with polyelectrolyte nanocapsules as biocide delivery vehicles.JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,54,15.
MLA Cai, Haoyuan,et al."pH-responsive linkages-enabled layer-by-layer assembled antibacterial and antiadhesive multilayer films with polyelectrolyte nanocapsules as biocide delivery vehicles".JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 54(2019):15.
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