Institutional Repository of Key Laboratory of Marine Environmental Corrosion and Bio-fouling, IOCAS
| pH-responsive linkages-enabled layer-by-layer assembled antibacterial and antiadhesive multilayer films with polyelectrolyte nanocapsules as biocide delivery vehicles | |
| Cai, Haoyuan1,2,3,4; Wang, Peng1,3,4; Zhang, Dun1,3,4 | |
| 2019-12-01 | |
| Source Publication | JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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| ISSN | 1773-2247 |
| Volume | 54Pages:15 |
| Abstract | Application of the polymer capsules as vehicles for antibacterial surface against bacterial infections is restricted by spontaneous leakage and specifically responsive release of antibacterial agents. Herein, we present the integration of pH-responsive nanocapsules as delivery tools for hydrophobic biocide within layer-by-layer (LbL) films utilizing alternating imine linkages as the driving force for assembly, thus enabling the introduction of drug and controlled release. The novel capsules are fabricated by means of electrostatic LbL assembly, namely, tannin acid/chitosan nanocapsules embedded with triclosan@cetyltrimethylammonium bromide micelles (TCS@CTAB/TA/CH). The nanocapsules achieve an excellent pH-responsive activity that the release efficiency of antibacterial agent triclosan (TCS) increases by nearly 61.8% from pH 8 to 4. Subsequently, the smart nanocapsules are alternatively incorporated via imine linkage into the dextran aldehyde (DA) polyelectrolyte multilayers in LbL deposition (denoted as (DA-TCS@CTAB/TA/CH)(n) films). The as-prepared samples are characterized by FTIR, FESEM, TEM, DLS and AFM. Noticeably, the (DA-TCS @CTAB/TA/CH)(20.5) film exhibites optimal pH-responsive activity with release concentration of TCS up to 4.01 mg/L at pH 6. The bacteriostatic percentages of (DA-TCS@CTAB/TA/CH)(20.5) against E. coll. and P. aeruginosa are respectively 99.62% and 97.35% after 24-h incubation at pH 6. Besides, the multilayers are capable of supplying a long-term (30 days) antibacterial property. The self-polishing mechanism of (DA-TCS@CTAB/TA/CH)(n) films is proposed to illuminate the enhanced antibacterial and antiadhesive performances. It seems that the films present a promising way to incorporate biocide to resist bacterial infections and prolong the antimicrobial activity of antibacterial surface. |
| Keyword | Antibacterial pH-responsive Layer-by-layer Self-polishing Antiadhesive |
| DOI | 10.1016/j.jddst.2019.101251 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[41922040] ; AoShan Talent Program ; Qingdao National Laboratory for Marine Science and Technology[2017ASTCP-ES02] ; National Natural Science Foundation of China[41576079] ; National Natural Science Foundation of China[41576079] ; Qingdao National Laboratory for Marine Science and Technology[2017ASTCP-ES02] ; AoShan Talent Program ; National Natural Science Foundation of China[41922040] |
| WOS Research Area | Pharmacology & Pharmacy |
| WOS Subject | Pharmacology & Pharmacy |
| WOS ID | WOS:000505159500080 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Version | 出版稿 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/164107 |
| Collection | 海洋环境腐蚀与与生物污损重点实验室 |
| Corresponding Author | Wang, Peng; Zhang, Dun |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Environm Corros & Biofouling, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China 2.Univ Chinese Acad Sci, 19 Jia Yuquan Rd, Beijing 100039, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Open Studio Marine Corros & Protect, 1 Wenhai Rd, Qingdao 266237, Shandong, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences; Center for Ocean Mega-Science, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences; Center for Ocean Mega-Science, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Cai, Haoyuan,Wang, Peng,Zhang, Dun. pH-responsive linkages-enabled layer-by-layer assembled antibacterial and antiadhesive multilayer films with polyelectrolyte nanocapsules as biocide delivery vehicles[J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,2019,54:15. |
| APA | Cai, Haoyuan,Wang, Peng,&Zhang, Dun.(2019).pH-responsive linkages-enabled layer-by-layer assembled antibacterial and antiadhesive multilayer films with polyelectrolyte nanocapsules as biocide delivery vehicles.JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,54,15. |
| MLA | Cai, Haoyuan,et al."pH-responsive linkages-enabled layer-by-layer assembled antibacterial and antiadhesive multilayer films with polyelectrolyte nanocapsules as biocide delivery vehicles".JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 54(2019):15. |
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| File Name/Size | DocType | Version | Access | License | ||
| pH-responsive linkag（5269KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View | |
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