Institutional Repository of Key Laboratory of Marine Environmental Corrosion and Bio-fouling, IOCAS
| pH-responsive linkages-enabled layer-by-layer assembled antibacterial and antiadhesive multilayer films with polyelectrolyte nanocapsules as biocide delivery vehicles | |
| Cai, Haoyuan1,2,3,4; Wang, Peng1,3,4; Zhang, Dun1,3,4 | |
| 2019-12-01 | |
| 发表期刊 | JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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| ISSN | 1773-2247 |
| 卷号 | 54页码:15 |
| 摘要 | Application of the polymer capsules as vehicles for antibacterial surface against bacterial infections is restricted by spontaneous leakage and specifically responsive release of antibacterial agents. Herein, we present the integration of pH-responsive nanocapsules as delivery tools for hydrophobic biocide within layer-by-layer (LbL) films utilizing alternating imine linkages as the driving force for assembly, thus enabling the introduction of drug and controlled release. The novel capsules are fabricated by means of electrostatic LbL assembly, namely, tannin acid/chitosan nanocapsules embedded with triclosan@cetyltrimethylammonium bromide micelles (TCS@CTAB/TA/CH). The nanocapsules achieve an excellent pH-responsive activity that the release efficiency of antibacterial agent triclosan (TCS) increases by nearly 61.8% from pH 8 to 4. Subsequently, the smart nanocapsules are alternatively incorporated via imine linkage into the dextran aldehyde (DA) polyelectrolyte multilayers in LbL deposition (denoted as (DA-TCS@CTAB/TA/CH)(n) films). The as-prepared samples are characterized by FTIR, FESEM, TEM, DLS and AFM. Noticeably, the (DA-TCS @CTAB/TA/CH)(20.5) film exhibites optimal pH-responsive activity with release concentration of TCS up to 4.01 mg/L at pH 6. The bacteriostatic percentages of (DA-TCS@CTAB/TA/CH)(20.5) against E. coll. and P. aeruginosa are respectively 99.62% and 97.35% after 24-h incubation at pH 6. Besides, the multilayers are capable of supplying a long-term (30 days) antibacterial property. The self-polishing mechanism of (DA-TCS@CTAB/TA/CH)(n) films is proposed to illuminate the enhanced antibacterial and antiadhesive performances. It seems that the films present a promising way to incorporate biocide to resist bacterial infections and prolong the antimicrobial activity of antibacterial surface. |
| 关键词 | Antibacterial pH-responsive Layer-by-layer Self-polishing Antiadhesive |
| DOI | 10.1016/j.jddst.2019.101251 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[41922040] ; AoShan Talent Program ; Qingdao National Laboratory for Marine Science and Technology[2017ASTCP-ES02] ; National Natural Science Foundation of China[41576079] ; National Natural Science Foundation of China[41576079] ; Qingdao National Laboratory for Marine Science and Technology[2017ASTCP-ES02] ; AoShan Talent Program ; National Natural Science Foundation of China[41922040] |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Pharmacology & Pharmacy |
| WOS记录号 | WOS:000505159500080 |
| 出版者 | ELSEVIER |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 版本 | 出版稿 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/164107 |
| 专题 | 海洋环境腐蚀与生物污损重点实验室 |
| 通讯作者 | Wang, Peng; Zhang, Dun |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Environm Corros & Biofouling, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China 2.Univ Chinese Acad Sci, 19 Jia Yuquan Rd, Beijing 100039, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Open Studio Marine Corros & Protect, 1 Wenhai Rd, Qingdao 266237, Shandong, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所; 中国科学院海洋大科学研究中心 |
| 通讯作者单位 | 中国科学院海洋研究所; 中国科学院海洋大科学研究中心 |
| 推荐引用方式 GB/T 7714 | Cai, Haoyuan,Wang, Peng,Zhang, Dun. pH-responsive linkages-enabled layer-by-layer assembled antibacterial and antiadhesive multilayer films with polyelectrolyte nanocapsules as biocide delivery vehicles[J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,2019,54:15. |
| APA | Cai, Haoyuan,Wang, Peng,&Zhang, Dun.(2019).pH-responsive linkages-enabled layer-by-layer assembled antibacterial and antiadhesive multilayer films with polyelectrolyte nanocapsules as biocide delivery vehicles.JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,54,15. |
| MLA | Cai, Haoyuan,et al."pH-responsive linkages-enabled layer-by-layer assembled antibacterial and antiadhesive multilayer films with polyelectrolyte nanocapsules as biocide delivery vehicles".JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 54(2019):15. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| pH-responsive linkag（5269KB） | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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