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Prenylated Phenol and Benzofuran Derivatives from Aspergillus terreus EN-539, an Endophytic Fungus Derived from Marine Red Alga Laurencia okamurai
Li, Hong-Lei1,2,3; Li, Xiao-Ming1,2,3; Yang, Sui-Qun1,2,3; Meng, Ling-Hong1,2,3; Li, Xin1,2,3; Wang, Bin-Gui1,2,3
2019-11-01
Source PublicationMARINE DRUGS
Volume17Issue:11Pages:9
Corresponding AuthorWang, Bin-Gui(wangbg@ms.qdio.ac.cn)
AbstractThree new prenylated phenol derivatives, terreprenphenols A-C (1-3), along with four known related compounds (4-7), were isolated from Aspergillus terreus EN-539, an endophytic fungus obtained from the marine red alga Laurencia okamurai. The structures of these compounds were established by extensive analysis of 1D/2D NMR data, mass spectrometric data, and optical rotation (OR). The corresponding relationship between absolute configuration and optical rotation for known compounds anodendroic acid (4) and asperterreusine C (5) was ambiguous in literature, and their absolute configurations were therefore discussed and confirmed for the first time by time-dependent density functional (TDDFT) ECD and OR calculations. Compounds 1-7 inhibited some common aquatic bacteria with MIC values ranging from 2 to 64 mu g/mL.
KeywordLaurencia okamurai Aspergillus terreus endophytic fungus prenylated phenol benzofuran antibacterial activity
DOI10.3390/md17110605
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31330009] ; Natural Science Foundation of Shandong Province[ZR2018BD031] ; China Postdoctoral Science Foundation[2018M632732]
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000502262200049
PublisherMDPI
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/164095
Collection实验海洋生物学重点实验室
Corresponding AuthorWang, Bin-Gui
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Shandong, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Hong-Lei,Li, Xiao-Ming,Yang, Sui-Qun,et al. Prenylated Phenol and Benzofuran Derivatives from Aspergillus terreus EN-539, an Endophytic Fungus Derived from Marine Red Alga Laurencia okamurai[J]. MARINE DRUGS,2019,17(11):9.
APA Li, Hong-Lei,Li, Xiao-Ming,Yang, Sui-Qun,Meng, Ling-Hong,Li, Xin,&Wang, Bin-Gui.(2019).Prenylated Phenol and Benzofuran Derivatives from Aspergillus terreus EN-539, an Endophytic Fungus Derived from Marine Red Alga Laurencia okamurai.MARINE DRUGS,17(11),9.
MLA Li, Hong-Lei,et al."Prenylated Phenol and Benzofuran Derivatives from Aspergillus terreus EN-539, an Endophytic Fungus Derived from Marine Red Alga Laurencia okamurai".MARINE DRUGS 17.11(2019):9.
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