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Particle and bacteria uptake by Japanese flounder (Paralichthys olivaceus) red blood cells: Size dependence and pathway specificity
Sun, Bin1,2,3; Sun, Yuan-yuan1,2; Lia, Xue-peng1,2; Jiang, Shuai1,2; Sun, Li1,2
2019-12-01
Source PublicationTISSUE & CELL
ISSN0040-8166
Volume61Pages:79-88
Corresponding AuthorSun, Li(lsun@qdio.ac.cn)
AbstractRed blood cells (RBCs) are traditionally considered non-professional phagocytes functioning predominately in oxygen transport. In the present study, we examined the ability of Japanese flounder (Paralichthys olivaceus), a teleost species with important economic values, RBCs to uptake inorganic particles and bacteria in different size/form, as well as the involving endocytic pathways. We found that flounder RBCs exhibited relatively high uptake/attachment capacities for 0.1 mu m-1.0 mu m (diameter) latex beads, but not for 2.0 mu m beads. For the 0.1 beads, the uptake/attachment was executed through macropinocytosis and caveolae-mediated pathway, while for 0.5 mu m and 1.0 mu m beads, the uptake/attachment depended primarily on macropinocytosis and partially on the caveolin-mediated pathway. In addition to latex beads, flounder RBCs also exhibited an apparent capacity to engulf both live and inactivated bacteria. For live bacteria, the endocytosis was clathrin-mediated, while for inactivated bacteria, clathrin- as well as non-clathrin-mediated endocytosis were involved. Taken together, these results demonstrated that teleost RBCs possess particle uptake/attachment and bacteria phagocytosis capacities via different pathways that depend on the physical size and biological nature of the engulfed objects.
KeywordRed blood cells/erythrocytes Paralichthys olivaceus Endocytosis Phagocytosis
DOI10.1016/j.tice.2019.09.002
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2018YFD0900500] ; Shandong Major Science and Technology Innovation Project[2018SDKJ0302-2] ; AoShan Talents Program ; Qingdao National Laboratory for Marine Science and Technology[2015ASTP] ; Taishan Scholar Program of Shandong Province
WOS Research AreaAnatomy & Morphology ; Cell Biology
WOS SubjectAnatomy & Morphology ; Cell Biology
WOS IDWOS:000497983800011
PublisherCHURCHILL LIVINGSTONE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/163826
Collection实验海洋生物学重点实验室
Corresponding AuthorSun, Li
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Sun, Bin,Sun, Yuan-yuan,Lia, Xue-peng,et al. Particle and bacteria uptake by Japanese flounder (Paralichthys olivaceus) red blood cells: Size dependence and pathway specificity[J]. TISSUE & CELL,2019,61:79-88.
APA Sun, Bin,Sun, Yuan-yuan,Lia, Xue-peng,Jiang, Shuai,&Sun, Li.(2019).Particle and bacteria uptake by Japanese flounder (Paralichthys olivaceus) red blood cells: Size dependence and pathway specificity.TISSUE & CELL,61,79-88.
MLA Sun, Bin,et al."Particle and bacteria uptake by Japanese flounder (Paralichthys olivaceus) red blood cells: Size dependence and pathway specificity".TISSUE & CELL 61(2019):79-88.
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