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Antimicrobial Sesquiterpenoid Derivatives and Monoterpenoids from the Deep-Sea Sediment-Derived Fungus Aspergillus versicolor SD-330
Li, Xiao-Dong1,2; Li, Xiao-Ming1,3,4; Yin, Xiu-Li2; Li, Xin1,3,4; Wang, Bin-Gui1,3,4
2019-10-01
Source PublicationMARINE DRUGS
Volume17Issue:10Pages:12
Corresponding AuthorLi, Xin(lixin@qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
AbstractTwo new antimicrobial bisabolane-type sesquiterpenoid derivatives, ent-aspergoterpenin C (compound 1) and 7-O-methylhydroxysydonic acid (2), and two new butyrolactone-type monoterpenoids, pestalotiolactones C (3) and D (4), along with a known monoterpenoid pestalotiolactone A (5) and four known bisabolane sesquiterpenoids (6-9), were isolated and identified from the deep-sea sediment-derived fungus Aspergillus versicolor SD-330. The structures of these compounds were elucidated on the basis of spectroscopic analysis, and the absolute configurations of the new compounds 1-4 were determined by the combination of NOESY and TDDFT-ECD calculations and X-ray crystallographic analysis. Additionally, we first determined and reported the absolute configuration of the known monoterpenoid pestalotiolactone A (5) through the X-ray crystallographic experiment. All of these isolated compounds were evaluated for antimicrobial activities against human and aquatic pathogenic bacteria. Compounds 1, 2, 6 and 9 exhibited selective inhibitory activities against zoonotic pathogenic bacteria such as Escherichia coli, Edwardsiella tarda, Vibrio anguillarum and V. harveyi, with MIC values ranging from 1.0 to 8.0 mu g/mL.
Keyworddeep-sea sediment-derived fungus Aspergillus versicolor bisabolane-type sesquiterpenoids monoterpenoids antimicrobial activity
DOI10.3390/md17100563
Indexed BySCI
Language英语
Funding ProjectStrategic Priority Research Program of the Chinese Academy of Sciences[XDA22050401] ; Aoshan Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2016ASKJ14] ; National Natural Science Foundation of China[31700043] ; China Postdoctoral Science Foundation[2016LH00033] ; China Postdoctoral Science Foundation[2017M612358] ; China Postdoctoral Science Foundation[2017M612360] ; Research Vessel KEXUE of the National Major Science and Technology Infrastructure from the Chinese Academy of Sciences[KEXUE2018G28] ; Taishan Scholar Project from Shandong Province ; Shandong Provincial Natural Science Foundation[ZR2017BB073]
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000498064500023
PublisherMDPI
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/163775
Collection实验海洋生物学重点实验室
Corresponding AuthorLi, Xin; Wang, Bin-Gui
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Chunhui Rd 17, Yantai 264003, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Shandong, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Xiao-Dong,Li, Xiao-Ming,Yin, Xiu-Li,et al. Antimicrobial Sesquiterpenoid Derivatives and Monoterpenoids from the Deep-Sea Sediment-Derived Fungus Aspergillus versicolor SD-330[J]. MARINE DRUGS,2019,17(10):12.
APA Li, Xiao-Dong,Li, Xiao-Ming,Yin, Xiu-Li,Li, Xin,&Wang, Bin-Gui.(2019).Antimicrobial Sesquiterpenoid Derivatives and Monoterpenoids from the Deep-Sea Sediment-Derived Fungus Aspergillus versicolor SD-330.MARINE DRUGS,17(10),12.
MLA Li, Xiao-Dong,et al."Antimicrobial Sesquiterpenoid Derivatives and Monoterpenoids from the Deep-Sea Sediment-Derived Fungus Aspergillus versicolor SD-330".MARINE DRUGS 17.10(2019):12.
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