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beta-glucan mitigated trinitrobenzene sulfonic acid-induced enteritis in the rainbow trout (Oncorhynchus mykiss)
Ji, Liqin1,2,3; Fu, Songzhe4; Ji, Renlei5; Li, Xian1,2; Liu, Ying2,4
2019-11-15
Source PublicationAQUACULTURE
ISSN0044-8486
Volume513Pages:9
Corresponding AuthorLiu, Ying(yingliu@dlou.edu.cn)
AbstractEnteritis is a common disease in fish which can be induced by a variety of factors. To study the effects of beta-glucan on enteritis of rainbow trout (Oncorhynchus mykiss), fish were administrated different beta-glucan levels (0, 0.1%, and 0.2%) for 30 days. Then individuals in all groups had enteritis induced with Trinitrobenzene Sulfonic Acid (TNBS) (75 mg per kg of body weight) and were sampled on 3, 6, and 9 days post inflammation (dpi). The growth data showed that 0.2% beta-glucan significantly improved the weight gain, specific growth rate, and feed efficiency (p < .05). The enteritis-induced weight loss percentage was largest on 6 dpi in all groups which was attenuated in the 0.2% beta-glucan group (BG) (p < .05). In addition, 0.1% and 0.2% beta-glucan dose-dependently decreased cumulative mortality rate during enteritis (p < .05). The intestinal histology and related scores of pathomorphological changes indicated that lesions of intestinal structure appeared on 3 dpi and became more severe on 6 dpi in all groups. Comparatively, intestinal lesions were the mildest in the 0.2% BG (p < .05). The changes of white blood cells, red blood cells, and hemoglobin in the 0.1% and 0.2% BG were smaller than in the control group post enteritis (p < .05). Besides that, enteritis increased serum antioxidant activities consisting of SOD, CAT, GSH, GSH-Px, MPO, and T-AOC. However, these increases were weakened in the 0.2% BG (p < .05). Lastly, 0.2% beta-glucan alleviated mRNA up-regulation of pro-inflammatory cytokines including il-1 beta, i1-6, and tnf-alpha in distal intestine, in contrast, it enhanced the mRNA up-regulation of anti-inflammatory cytokine il-10 and host defense peptides including cath-1 and cath-2 < .05). To sum up, this is the first study to induce enteritis with TNBS in rainbow trout. Besides that, 0.1% and 0.2% beta-glucan could dose-dependently mitigate TNBS-induced enteritis in rainbow trout. This research provides the evidence to support beta-glucan as a therapeutic or protective substance in commercial fish enteritis.
Keywordbeta-glucan TNBS Enteritis Rainbow trout
DOI10.1016/j.aquaculture.2019.734393
Indexed BySCI
Language英语
Funding ProjectNational Key Technologies RD Program[2017YFB0404000] ; Key Technologies R&D Program of Shandong Province[2018GHY115031]
WOS Research AreaFisheries ; Marine & Freshwater Biology
WOS SubjectFisheries ; Marine & Freshwater Biology
WOS IDWOS:000497647200011
PublisherELSEVIER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/163754
Collection实验海洋生物学重点实验室
Corresponding AuthorLiu, Ying
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266235, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
4.Dalian Ocean Univ, Sch Marine Sci & Environm Engn, 52 Heroitte St, Dalian 116023, Peoples R China
5.Auburn Univ, Coll Vet Med, Dept Anat Physiol & Pharmacol, Auburn, AL 36849 USA
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Ji, Liqin,Fu, Songzhe,Ji, Renlei,et al. beta-glucan mitigated trinitrobenzene sulfonic acid-induced enteritis in the rainbow trout (Oncorhynchus mykiss)[J]. AQUACULTURE,2019,513:9.
APA Ji, Liqin,Fu, Songzhe,Ji, Renlei,Li, Xian,&Liu, Ying.(2019).beta-glucan mitigated trinitrobenzene sulfonic acid-induced enteritis in the rainbow trout (Oncorhynchus mykiss).AQUACULTURE,513,9.
MLA Ji, Liqin,et al."beta-glucan mitigated trinitrobenzene sulfonic acid-induced enteritis in the rainbow trout (Oncorhynchus mykiss)".AQUACULTURE 513(2019):9.
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