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Dietary beta-glucan modulate haematological parameters, cytokines and gene expression in TLR and ERK pathways of rainbow trout (Oncorhynchus mykiss) during infection by Aeromonas salmonicida
Ji, Liqin1,2,3,4; Fu, Songzhe5; Sun, Guoxiang1; Li, Xian1,2,4; Liu, Ying2,5
2019-12-13
Source PublicationAQUACULTURE RESEARCH
ISSN1355-557X
Pages12
Corresponding AuthorLiu, Ying(yingliu@dlou.edu.cn)
AbstractTo explore the role of beta-glucan (0, 0.05%, 0.1% and 0.2%) in resisting bacteria, rainbow trout (Oncorhynchus mykiss) was challenged with Aeromonas salmonicida after 42-day beta-glucan administration, and then sampled at 0, 2, 4 and 6 days post infection (dpi). The data showed that 0.2% beta-glucan reduced the accumulated mortality rates compared with the ICG (infected control group) (p ). The white blood cells, red blood cells and haemoglobin were higher in the 0.2% beta-glucan group (BG) than the ICG (p ). 0.1% and 0.2% beta-glucan elevated serum total antioxidative capability and glutathione activity but alleviated the increase of serum alkaline phosphatase activity and glucose concentration (p < .05) during infection. Serum TNF-alpha, IL-1 beta, IL-8 and IgM in three BGs elevated remarkably on 6 dpi compared with the ICG (p ). Expression of tnf, il1b and cxcl8 of the head kidney in the 0.1% and 0.2% BGs was higher than the ICG on 4 dpi while ighm expression in the 0.2% BG was higher than in the ICG on 2 and 6 dpi (p ). 0.1% and 0.2% beta-glucan increased the expression of tlr5m, tlr5s, tmek and myd88 in the spleen after infection (p < .05). Similarly, 0.2% beta-glucan up-regulated the expression of tmek, myd88, oncmyk-dab and c3 in head kidney (p < .05). Overall, 0.2% dietary beta-glucan effectively decreased accumulated mortality rate by modulating the biochemistry process, cytokines, and activating TLR and ERK signalling pathways during A. salmonicida infection.
KeywordAeromonas salmonicida cytokines rainbow trout TLR and ERK signalling pathways beta-glucans
DOI10.1111/are.14436
Indexed BySCI
Language英语
Funding ProjectNational Key Technologies RD Program[2017YFB0404000] ; National key R&D Program of China[2017YFD0701700] ; Key R&D Program of Guangdong Province[2019B020215001] ; National Natural Science Founds[31672673] ; Key Technologies R&D Program of Shandong Province[2018GHY115031]
WOS Research AreaFisheries
WOS SubjectFisheries
WOS IDWOS:000502358400001
PublisherWILEY
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/163751
Collection实验海洋生物学重点实验室
Corresponding AuthorLiu, Ying
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Shandong, Peoples R China
5.Dalian Ocean Univ, Sch Marine Sci & Environm Engn, 52 Heroitte St, Dalian 116023, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Ji, Liqin,Fu, Songzhe,Sun, Guoxiang,et al. Dietary beta-glucan modulate haematological parameters, cytokines and gene expression in TLR and ERK pathways of rainbow trout (Oncorhynchus mykiss) during infection by Aeromonas salmonicida[J]. AQUACULTURE RESEARCH,2019:12.
APA Ji, Liqin,Fu, Songzhe,Sun, Guoxiang,Li, Xian,&Liu, Ying.(2019).Dietary beta-glucan modulate haematological parameters, cytokines and gene expression in TLR and ERK pathways of rainbow trout (Oncorhynchus mykiss) during infection by Aeromonas salmonicida.AQUACULTURE RESEARCH,12.
MLA Ji, Liqin,et al."Dietary beta-glucan modulate haematological parameters, cytokines and gene expression in TLR and ERK pathways of rainbow trout (Oncorhynchus mykiss) during infection by Aeromonas salmonicida".AQUACULTURE RESEARCH (2019):12.
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