The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer
Wang, Man1; Jiang, Shuai2; Zhang, Yinfeng1; Li, Peifeng1; Wang, Kun1
Source PublicationCANCERS
Corresponding AuthorWang, Man( ; Wang, Kun(
AbstractCancer is a category of diseases involving abnormal cell growth with the potential to invade other parts of the body. Chemotherapy is the most widely used first-line treatment for multiple forms of cancer. Chemotherapeutic agents act via targeting the cellular apoptotic pathway. However, cancer cells usually acquire chemoresistance, leading to poor outcomes in cancer patients. For that reason, it is imperative to discover other cell death pathways for improved cancer intervention. Pyroptosis is a new form of programmed cell death that commonly occurs upon pathogen invasion. Pyroptosis is marked by cell swelling and plasma membrane rupture, which results in the release of cytosolic contents into the extracellular space. Currently, pyroptosis is proposed to be an alternative mode of cell death in cancer treatment. Accumulating evidence shows that the key components of pyroptotic cell death pathways, including inflammasomes, gasdermins and pro-inflammatory cytokines, are involved in the initiation and progression of cancer. Interfering with pyroptotic cell death pathways may represent a promising therapeutic option for cancer management. In this review, we describe the current knowledge regarding the biological significance of pyroptotic cell death pathways in cancer pathogenesis and also discuss their potential therapeutic utility.
Keywordpyroptosis cancer inflammasome gasdermin pro-inflammatory cytokine cancer pathogenesis therapeutic utility
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81701991] ; Applied Basic Research Programs of Qingdao, China[17-1-1-59-jch]
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000489719000098
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Document Type期刊论文
Corresponding AuthorWang, Man; Wang, Kun
Affiliation1.Qingdao Univ, Inst Translat Med, Med Coll, Dengzhou Rd 38, Qingdao 266021, Shandong, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Man,Jiang, Shuai,Zhang, Yinfeng,et al. The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer[J]. CANCERS,2019,11(9):26.
APA Wang, Man,Jiang, Shuai,Zhang, Yinfeng,Li, Peifeng,&Wang, Kun.(2019).The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer.CANCERS,11(9),26.
MLA Wang, Man,et al."The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer".CANCERS 11.9(2019):26.
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