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The antiviral property of Sargassum fusiforme polysaccharide for avian leukosis virus subgroup J in vitro and in vivo
Sun, Yuhao1,2,3; Chen, Xiaolin1,2; Zhang, Lili4; Liu, Hong1,2,3; Liu, Song1,2; Yu, Huahua1,2; Wang, Xueqin1,2; Qin, Yukun1,2; Li, Pengcheng1,2
2019-10-01
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
Volume138Pages:70-78
Corresponding AuthorChen, Xiaolin(chenzl@odio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
AbstractAvian Leukosis Virus Subgroup J.(ALV-J) is an oncogenic retrovirus, mainly spread by vertical and horizontal transmission, which have caused severe losses in world poultry industry. Sargassum fusiforme polysaccharide (SFP), a marine algae sulfated polysaccharide, has attracted more attention due to its variously biological activities. In this study, the anti-ALV-J property of SFP was assessed in vivo and in vitro. The results demonstrated that different Mw of SFPs showed virustatic activity to ALV-J in vitro by combining with the virus when ALV-J adsorbed onto the host cells. When treated with SFPs, the ALV-J gene and protein expression reduced clearly and SFP-3 (Molecular weight 9 kDa) had the best antiviral effect. Results in vivo showed that the immunosuppression of the ALV-J infected chickens were relieved by SFP-3. Moreover, SFP-3 obviously inhibit the viral shedding and alleviated the organs damage caused by ALV-J. This study offered a new method for ALV-J treatment and enriched the potential application of SFP. (C) 2019 Elsevier B.V. All rights reserved.
KeywordSargassum fusiforme Polysaccharide Antiviral
DOI10.1016/j.ijbiomac2019.07.073
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2018YFD0901104] ; Shandong Province Key Research and Development Project[2018GHY115008] ; Shandong Province Key Research and Development Project[2017GHY215008] ; Qingdao Science and Technology Project[17-3-3-60-nsh]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS IDWOS:000487569000008
PublisherELSEVIER
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Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/163405
Collection实验海洋生物学重点实验室
Corresponding AuthorChen, Xiaolin; Li, Pengcheng
Affiliation1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266071, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Shandong Agr Univ, Coll Chem & Mat Sci, Tai An 271018, Shandong, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Sun, Yuhao,Chen, Xiaolin,Zhang, Lili,et al. The antiviral property of Sargassum fusiforme polysaccharide for avian leukosis virus subgroup J in vitro and in vivo[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2019,138:70-78.
APA Sun, Yuhao.,Chen, Xiaolin.,Zhang, Lili.,Liu, Hong.,Liu, Song.,...&Li, Pengcheng.(2019).The antiviral property of Sargassum fusiforme polysaccharide for avian leukosis virus subgroup J in vitro and in vivo.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,138,70-78.
MLA Sun, Yuhao,et al."The antiviral property of Sargassum fusiforme polysaccharide for avian leukosis virus subgroup J in vitro and in vivo".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 138(2019):70-78.
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