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Antioxidant defenses and immune responses of flounder Paralichthys olivaceus larvae under methylmercury exposure
Ren, Zhonghua1,3; Liu, Jinhu1,2; Huang, Wei4; Cao, Liang1,2; Cui, Wenting1,3; Dou, Shuozeng1,2,3
2019-11-01
发表期刊COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
ISSN1532-0456
卷号225页码:11
通讯作者Cao, Liang(caoliang@qdio.ac.cn) ; Dou, Shuozeng(szdou@qdio.ac.cn)
摘要Methylmercury (MeHg) is a highly toxic contaminant in coastal environments and poses threats to marine fish in early life stages (ELSs). However, MeHg toxicity to fish embryos and larvae is not well investigated. This study investigated the antioxidant defenses and immune responses of flounder Paralichthys olivaceus larvae exposed to waterborne MeHg (0, 0.1, 1.0 and 10.0 mu g L-1) for 35 days, from embryogenesis to settlement. The results revealed that metal accumulation in the larvae was positively correlated with MeHg concentration, reduced larval growth and survival. The activities of catalase and glutathione reductase were significantly increased at 10.0 mu g L-1, while glutathione peroxidase activity and lipid peroxidation level were significantly increased at concentrations over 1.0 mu g L-1. The corresponding antioxidant-related genes were upregulated under MeHg exposure (cat and gpx at 10.0 mu g L-1; gr over 1.0 mu g L-1). Lysozyme content was significantly increased, but immunoglobulin M content was significantly decreased at 10.0 mu g L-1. The immune-related genes were significantly upregulated (hsp70 at 0.1 and 10.0 mu g L-1; lzm and il-1 beta over 1.0 mu g L-1; tnf-alpha and il-6 at 10.0 mu g L-1) or downregulated (igm, over 0.1 mu g L-1). Overall, MeHg exposure induced oxidative stress and caused immunotoxicity at concentrations over 1.0 mu g L-1 and 10.0 mu g L-1, respectively. The transcription of selected genes correlated with the corresponding biochemical markers in response to MeHg toxicity. These findings improve our knowledge to better understand the mechanisms by which marine fish at ELSs cope with oxidative stress and immunotoxicity induced by MeHg.
关键词Metal accumulation Larval growth Biochemical markers Gene transcription Oxidative stress Immunotoxicity
DOI10.1016/j.cbpc.2019.108589
收录类别SCI
语种英语
资助项目National Key Basic Research Program[2015CB453302] ; National Natural Science Foundation of China[41406176] ; National Natural Science Foundation of China[41306112] ; National Key Basic Research Program[2015CB453302] ; National Natural Science Foundation of China[41406176] ; National Natural Science Foundation of China[41306112]
WOS研究方向Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology
WOS类目Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology
WOS记录号WOS:000488304600018
出版者ELSEVIER SCIENCE INC
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/163221
专题海洋生态与环境科学重点实验室
通讯作者Cao, Liang; Dou, Shuozeng
作者单位1.Chinese Acad Sci, Ctr Ocean Mega Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266071, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
4.State Ocean Adm, Inst Oceanog 2, Key Lab Marine Ecosyst & Biogeochem, Hangzhou 310000, Zhejiang, Peoples R China
第一作者单位中国科学院海洋研究所
通讯作者单位中国科学院海洋研究所
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GB/T 7714
Ren, Zhonghua,Liu, Jinhu,Huang, Wei,et al. Antioxidant defenses and immune responses of flounder Paralichthys olivaceus larvae under methylmercury exposure[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,2019,225:11.
APA Ren, Zhonghua,Liu, Jinhu,Huang, Wei,Cao, Liang,Cui, Wenting,&Dou, Shuozeng.(2019).Antioxidant defenses and immune responses of flounder Paralichthys olivaceus larvae under methylmercury exposure.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,225,11.
MLA Ren, Zhonghua,et al."Antioxidant defenses and immune responses of flounder Paralichthys olivaceus larvae under methylmercury exposure".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 225(2019):11.
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