Chinikomycins A and B: Isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp isolate M045

doi:10.1021/np030518r

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	Chinikomycins A and B: Isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp isolate M045
	Li, FC ; Maskey, RP ; Qin, S ; Sattler, I ; Fiebig, HH ; Maier, A ; Zeeck, A ; Laatsch, H ; Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany
	2005-03-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	68 期号:3 页码:349-353
文章类型	Article
摘要	In our screening of marine Streptomycetes for bioactive principles, two novel antitumor antibiotics designated as chinikomycins A (2a) and B (2b) were isolated together with manumycin A (1), and their structures were elucidated by a detailed interpretation of their spectra. Chinikomycins A (2a) and B (2b) are chlorine-containing aromatized manumycin derivatives of the type 64-pABA-2 with an unusual para orientation of the side chains. They exhibited antitumor activity against different human cancer cell lines, but were inactive in antiviral, antimicrobial, and phytotoxicity tests.; In our screening of marine Streptomycetes for bioactive principles, two novel antitumor antibiotics designated as chinikomycins A (2a) and B (2b) were isolated together with manumycin A (1), and their structures were elucidated by a detailed interpretation of their spectra. Chinikomycins A (2a) and B (2b) are chlorine-containing aromatized manumycin derivatives of the type 64-pABA-2 with an unusual para orientation of the side chains. They exhibited antitumor activity against different human cancer cell lines, but were inactive in antiviral, antimicrobial, and phytotoxicity tests.
关键词	Manumycin
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1021/np030518r
URL	查看原文
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000227927700008
引用统计	被引频次：77[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/1629
专题	实验海洋生物学重点实验室
通讯作者	Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany
作者单位	1.Univ Gottingen, Dept Organ & Biomol Chem, D-37077 Gottingen, Germany 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Oncotest GmbH, D-79108 Freiburg, Germany
推荐引用方式 GB/T 7714	Li, FC,Maskey, RP,Qin, S,et al. Chinikomycins A and B: Isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp isolate M045[J]. JOURNAL OF NATURAL PRODUCTS,2005,68(3):349-353.
APA	Li, FC.,Maskey, RP.,Qin, S.,Sattler, I.,Fiebig, HH.,...&Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany.(2005).Chinikomycins A and B: Isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp isolate M045.JOURNAL OF NATURAL PRODUCTS,68(3),349-353.
MLA	Li, FC,et al."Chinikomycins A and B: Isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp isolate M045".JOURNAL OF NATURAL PRODUCTS 68.3(2005):349-353.

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