IOCAS-IR
Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea
Yan, Pengcheng1; Li, Ge; Wang, Chaojie; Wu, Jianzhang1; Sun, Zhongmin2; Martin, Gary E.3; Wang, Xiao4; Reibarkh, Mikhail4; Sauri, Josep5; Gustafson, Kirk R.1,6
2019-09-20
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号21期号:18页码:7577-7581
通讯作者Yan, Pengcheng(yanpc@wmu.edu.cn) ; Wu, Jianzhang(wujianzhang@wmu.edu.cn) ; Gustafson, Kirk R.(gustafki@mail.nih.gov)
摘要The challenging structural motif of dictyospiromide (1), a spirosuccinimide alkaloid with antioxidant properties that are associated with activation of the Nrf2/ARE signaling pathway, was assigned using contemporary NMR experiments complemented with anisotropic NMR, chiroptical, and computational methodologies. Anisotropic NMR parameters provided critical orthogonal verification of the configuration of the difficult to assign spiro carbon and the other stereogenic centers in 1.
DOI10.1021/acs.orglett.9b02856
收录类别SCI
语种英语
资助项目Natural Science Foundation of Zhejiang Province, China[LQ19H300003] ; Natural Science Foundation of Zhejiang Province, China[Y19B020043] ; Public Project of Zhejiang Province[2017C37042] ; Outstanding Youth Foundation from Wenzhou Medical University[604091809] ; Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences[201707] ; Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research ; Natural Science Foundation of Zhejiang Province, China[LQ19H300003] ; Natural Science Foundation of Zhejiang Province, China[Y19B020043] ; Public Project of Zhejiang Province[2017C37042] ; Outstanding Youth Foundation from Wenzhou Medical University[604091809] ; Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences[201707] ; Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000487577200081
出版者AMER CHEMICAL SOC
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/162987
专题中国科学院海洋研究所
通讯作者Yan, Pengcheng; Wu, Jianzhang; Gustafson, Kirk R.
作者单位1.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China
3.Seton Hall Univ, Dept Chem & Biochem, S Orange, NJ 07079 USA
4.Merck & Co Inc, Analyt Res & Dev, Struct Elucidat Grp, Rahway, NJ 07065 USA
5.Merck & Co Inc, Analyt Res & Dev, Struct Elucidat Grp, Boston, MA 02115 USA
6.NCI, Ctr Canc Res, Mol Targets Program, Frederick, MD 21702 USA
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GB/T 7714
Yan, Pengcheng,Li, Ge,Wang, Chaojie,et al. Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea[J]. ORGANIC LETTERS,2019,21(18):7577-7581.
APA Yan, Pengcheng.,Li, Ge.,Wang, Chaojie.,Wu, Jianzhang.,Sun, Zhongmin.,...&Gustafson, Kirk R..(2019).Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea.ORGANIC LETTERS,21(18),7577-7581.
MLA Yan, Pengcheng,et al."Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea".ORGANIC LETTERS 21.18(2019):7577-7581.
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