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Structure, absolute configuration and biological evaluation of polyoxygenated meroterpenoids from the marine algal-derived Aspergillus terreus EN-539
Li, Hong-Lei1,2,3; Li, Xiao-Ming1,2,3; Li, Xin1,2,3; Yang, Sui-Qun1,2,3; Wang, Bin-Gui1,2,3
2019-08-01
Source PublicationPHYTOCHEMISTRY LETTERS
ISSN1874-3900
Volume32Pages:138-142
Corresponding AuthorWang, Bin-Gui(wangbg@ms.qdio.ac.cn)
AbstractTwo new meroterpenoids, aperterpenes N (1) and O (2), along with two known structurally related derivatives, terretonins A (3) and G (4), were isolated and identified from the marine algal-derived endophytic fungus Aspergillus terreus EN-539. Their structures and absolute configurations were determined by a detailed interpretation of spectroscopic data and by X-ray crystallographic analysis. This is the first establishment of the absolute configurations for terretonins A (3) and G (4). Compound 1 showed inhibitory activity against influenza neuraminidase (IC50 = 18.0 nM), and compound 4 showed inhibitory activity against Micrococcus luteus and Staphylococcus aureus, with MIC values of 32 and 8 mu g/mL, respectively.
KeywordAspergillus terreus Laurencia okamurai Meroterpenoids Influenza neuraminidase inhibitor Antibacterial activity
DOI10.1016/j.phytol.2019.05.017
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31330009] ; Natural Science Foundation of Shandong Province[ZR2018BD031] ; China Postdoctoral Science Foundation[2018M632732] ; Taishan Scholar Program from Shandong Province
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal
WOS IDWOS:000476725000027
PublisherELSEVIER
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/162772
Collection实验海洋生物学重点实验室
Corresponding AuthorWang, Bin-Gui
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Shandong, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Hong-Lei,Li, Xiao-Ming,Li, Xin,et al. Structure, absolute configuration and biological evaluation of polyoxygenated meroterpenoids from the marine algal-derived Aspergillus terreus EN-539[J]. PHYTOCHEMISTRY LETTERS,2019,32:138-142.
APA Li, Hong-Lei,Li, Xiao-Ming,Li, Xin,Yang, Sui-Qun,&Wang, Bin-Gui.(2019).Structure, absolute configuration and biological evaluation of polyoxygenated meroterpenoids from the marine algal-derived Aspergillus terreus EN-539.PHYTOCHEMISTRY LETTERS,32,138-142.
MLA Li, Hong-Lei,et al."Structure, absolute configuration and biological evaluation of polyoxygenated meroterpenoids from the marine algal-derived Aspergillus terreus EN-539".PHYTOCHEMISTRY LETTERS 32(2019):138-142.
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