Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Genome-wide association analysis of nutrient traits in the oyster Crassostrea gigas: genetic effect and interaction network | |
Meng, Jie1,4,5; Song, Kai1,4,5; Li, Chunyan1,4,6; Liu, Sheng1,4,6; Shi, Ruihui1,4,6; Li, Busu1,4,6; Wang, Ting1,4,6; Li, Ao1,4,6; Que, Huayong1,2,4,5; Li, Li1,3,4,5; Zhang, Guofan1,2,4,5 | |
2019-07-31 | |
发表期刊 | BMC GENOMICS |
ISSN | 1471-2164 |
卷号 | 20期号:1页码:14 |
通讯作者 | Li, Li(lili@qdio.ac.cn) ; Zhang, Guofan(gfzhang@qdio.ac.cn) |
摘要 | Background: Oyster is rich in glycogen and free amino acids and is called "the milk of sea". To understand the main genetic effects of these traits and the genetic networks underlying their correlation, we have conducted the whole genome resequencing with 427 oysters collected from the world-wide scale. Results: After association analysis, 168 clustered significant single nucleotide polymorphism (SNP) loci were identified for glycogen content and 17 SNPs were verified with 288 oyster individuals in another wide populations. These were the most important candidate loci for oyster breeding. Among 24 genes in the 100-kb regions of the leading SNP loci, cytochrome P450 17A1 (CYP17A1) contained a non-synonymous SNP and displayed higher expressions in high glycogen content individuals. This might enhance the gluconeogenesis process by the transcriptionally regulating the expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase). Also, for amino acids content 417 clustered significant SNPs were identified. After genetic network analysis, three node SNP regions were identified to be associated with glycogen, protein, and Asp content, which might explain their significant correlation. Conclusion: Overall, this study provides insights into the genetic correlation among complex traits, which will facilitate future oyster functional studies and breeding through molecular design. |
关键词 | Oyster Nutrient traits Genome resequencing Population structure Genome-wide association study Genetic network |
DOI | 10.1186/s12864-019-5971-z |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[31530079] ; earmarked fund for Modern Agro-industry Technology Research System[CARS-49] ; Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02-03] ; Qingdao National Laboratory for Marine Science and Technology[2017-2B07] ; Shandong Provincial Natural Science Foundation of China[ZR2016DQ13] ; Laboratory for Marine Fisheries Science and Food Production Processes ; National Natural Science Foundation of China[31530079] ; Earmarked Fund for Modern Agro-industry Technology Research System[CARS-49] ; Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02-03] ; Qingdao National Laboratory for Marine Science and Technology[2017-2B07] ; Shandong Provincial Natural Science Foundation of China[ZR2016DQ13] ; Laboratory for Marine Fisheries Science and Food Production Processes |
WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
WOS记录号 | WOS:000482318400004 |
出版者 | BMC |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/162757 |
专题 | 实验海洋生物学重点实验室 |
通讯作者 | Li, Li; Zhang, Guofan |
作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Shandong, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries & Aquaculture, Qingdao 266071, Shandong, Peoples R China 4.Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Shandong, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
第一作者单位 | 中国科学院海洋研究所 |
通讯作者单位 | 中国科学院海洋研究所 |
推荐引用方式 GB/T 7714 | Meng, Jie,Song, Kai,Li, Chunyan,et al. Genome-wide association analysis of nutrient traits in the oyster Crassostrea gigas: genetic effect and interaction network[J]. BMC GENOMICS,2019,20(1):14. |
APA | Meng, Jie.,Song, Kai.,Li, Chunyan.,Liu, Sheng.,Shi, Ruihui.,...&Zhang, Guofan.(2019).Genome-wide association analysis of nutrient traits in the oyster Crassostrea gigas: genetic effect and interaction network.BMC GENOMICS,20(1),14. |
MLA | Meng, Jie,et al."Genome-wide association analysis of nutrient traits in the oyster Crassostrea gigas: genetic effect and interaction network".BMC GENOMICS 20.1(2019):14. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
s12864-019-5971-z.pd(3817KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
Genome-wide associat(3817KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论