| Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions |
| Shi, Xiaolin1,2,3; Li, Xiaowei1,2,3 ; Li, Xiangqian4; Shi, Dayong4
|
| 2019-09-06
|
| Source Publication | FRONTIERS IN CHEMISTRY
 |
| ISSN | 2296-2646
|
| Volume | 7Pages:10 |
| Corresponding Author | Li, Xiangqian(xqli@qdio.ac.cn)
; Shi, Dayong(shidayong@sdu.edu.cn)
|
| Abstract | A highly selective copper-catalyzed trifluoromethylation of indoles is reported with the assistance of a removable directing group. This protocol provides an easy and rapid method to various 2-position-selective trifluoromethylated heteroarenes including indoles, pyrroles, benzofuran, and acetanilide. What is more, the reaction takes place at ambient conditions without any external ligand or additive. |
| Keyword | C-H functionalization
trifluoromethylation
indoles
copper
radical reaction
|
| DOI | 10.3389/fchem.2019.00613
|
| Indexed By | SCI
|
| Language | 英语
|
| Funding Project | National Natural Science Foundation of China[81773586]
; National Natural Science Foundation of China[81703354]
; Key research and development project of Shandong province[2016GSF201193]
; Key research and development project of Shandong province[2016ZDJS07A13]
; Key research and development project of Shandong province[2016GSF115002]
; Key research and development project of Shandong province[2016GSF115009]
; CAS[QYZDB-SSW-DQC014]
; Project of Discovery, Evaluation and Transformation of Active Natural Compounds
; Chinese Academy of Sciences[ZSTH-026]
; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722]
; National Program for Support of Top-notch Young Professionals
; Taishan scholar Youth Project of Shandong province
; National Natural Science Foundation of China[81773586]
; National Natural Science Foundation of China[81703354]
; Key research and development project of Shandong province[2016GSF201193]
; Key research and development project of Shandong province[2016ZDJS07A13]
; Key research and development project of Shandong province[2016GSF115002]
; Key research and development project of Shandong province[2016GSF115009]
; CAS[QYZDB-SSW-DQC014]
; Project of Discovery, Evaluation and Transformation of Active Natural Compounds
; Chinese Academy of Sciences[ZSTH-026]
; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722]
; National Program for Support of Top-notch Young Professionals
; Taishan scholar Youth Project of Shandong province
|
| WOS Research Area | Chemistry
|
| WOS Subject | Chemistry, Multidisciplinary
|
| WOS ID | WOS:000484497100001
|
| Publisher | FRONTIERS MEDIA SA
|
| Citation statistics |
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| Document Type | 期刊论文
|
| Identifier | http://ir.qdio.ac.cn/handle/337002/162691
|
| Collection | 实验海洋生物学重点实验室
|
| Corresponding Author | Li, Xiangqian; Shi, Dayong |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Shandong Univ, State Key Lab Microbial Technol, Qingdao, Shandong, Peoples R China
|
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences
|
Recommended Citation
GB/T 7714 |
Shi, Xiaolin,Li, Xiaowei,Li, Xiangqian,et al. Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions[J]. FRONTIERS IN CHEMISTRY,2019,7:10.
|
| APA |
Shi, Xiaolin,Li, Xiaowei,Li, Xiangqian,&Shi, Dayong.(2019).Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions.FRONTIERS IN CHEMISTRY,7,10.
|
| MLA |
Shi, Xiaolin,et al."Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions".FRONTIERS IN CHEMISTRY 7(2019):10.
|
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