Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions

doi:10.3389/fchem.2019.00613

IOCAS-IR > 实验海洋生物学重点实验室

	Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions
	Shi, Xiaolin 1,2,3; Li, Xiaowei1,2,3 ; Li, Xiangqian 4; Shi, Dayong 4
	2019-09-06
Source Publication	FRONTIERS IN CHEMISTRY
ISSN	2296-2646
Volume	7 Pages:10
Corresponding Author	Li, Xiangqian(xqli@qdio.ac.cn) ; Shi, Dayong(shidayong@sdu.edu.cn)
Abstract	A highly selective copper-catalyzed trifluoromethylation of indoles is reported with the assistance of a removable directing group. This protocol provides an easy and rapid method to various 2-position-selective trifluoromethylated heteroarenes including indoles, pyrroles, benzofuran, and acetanilide. What is more, the reaction takes place at ambient conditions without any external ligand or additive.
Keyword	C-H functionalization trifluoromethylation indoles copper radical reaction
DOI	10.3389/fchem.2019.00613
Indexed By	SCI
Language	英语
Funding Project	National Natural Science Foundation of China[81773586] ; National Natural Science Foundation of China[81703354] ; Key research and development project of Shandong province[2016GSF201193] ; Key research and development project of Shandong province[2016ZDJS07A13] ; Key research and development project of Shandong province[2016GSF115002] ; Key research and development project of Shandong province[2016GSF115009] ; CAS[QYZDB-SSW-DQC014] ; Project of Discovery, Evaluation and Transformation of Active Natural Compounds ; Chinese Academy of Sciences[ZSTH-026] ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722] ; National Program for Support of Top-notch Young Professionals ; Taishan scholar Youth Project of Shandong province
WOS Research Area	Chemistry
WOS Subject	Chemistry, Multidisciplinary
WOS ID	WOS:000484497100001
Publisher	FRONTIERS MEDIA SA
Citation statistics	Cited Times:2[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.qdio.ac.cn/handle/337002/162691
Collection	实验海洋生物学重点实验室
Corresponding Author	Li, Xiangqian; Shi, Dayong
Affiliation	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Shandong, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Shandong Univ, State Key Lab Microbial Technol, Qingdao, Shandong, Peoples R China
First Author Affilication	Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation GB/T 7714	Shi, Xiaolin,Li, Xiaowei,Li, Xiangqian,et al. Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions[J]. FRONTIERS IN CHEMISTRY,2019,7:10.
APA	Shi, Xiaolin,Li, Xiaowei,Li, Xiangqian,&Shi, Dayong.(2019).Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions.FRONTIERS IN CHEMISTRY,7,10.
MLA	Shi, Xiaolin,et al."Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions".FRONTIERS IN CHEMISTRY 7(2019):10.

Files in This Item:
File Name/Size	DocType	Version	Access	License
Shi-2019-Ligand--and（988KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	View Application Full Text

File name:	Shi-2019-Ligand--and-additive-free--position.pdf
Format:	Adobe PDF

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Institution:
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh

实验海洋生物学重点实验室知识库