Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions | |
Shi, Xiaolin1,2,3; Li, Xiaowei1,2,3 ; Li, Xiangqian4; Shi, Dayong4
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| 2019-09-06 | |
| Source Publication | FRONTIERS IN CHEMISTRY
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| ISSN | 2296-2646 |
| Volume | 7Pages:10 |
| Corresponding Author | Li, Xiangqian(xqli@qdio.ac.cn) ; Shi, Dayong(shidayong@sdu.edu.cn) |
| Abstract | A highly selective copper-catalyzed trifluoromethylation of indoles is reported with the assistance of a removable directing group. This protocol provides an easy and rapid method to various 2-position-selective trifluoromethylated heteroarenes including indoles, pyrroles, benzofuran, and acetanilide. What is more, the reaction takes place at ambient conditions without any external ligand or additive. |
| Keyword | C-H functionalization trifluoromethylation indoles copper radical reaction |
| DOI | 10.3389/fchem.2019.00613 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[81773586] ; National Natural Science Foundation of China[81703354] ; Key research and development project of Shandong province[2016GSF201193] ; Key research and development project of Shandong province[2016ZDJS07A13] ; Key research and development project of Shandong province[2016GSF115002] ; Key research and development project of Shandong province[2016GSF115009] ; CAS[QYZDB-SSW-DQC014] ; Project of Discovery, Evaluation and Transformation of Active Natural Compounds ; Chinese Academy of Sciences[ZSTH-026] ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722] ; National Program for Support of Top-notch Young Professionals ; Taishan scholar Youth Project of Shandong province |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Multidisciplinary |
| WOS ID | WOS:000484497100001 |
| Publisher | FRONTIERS MEDIA SA |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/162691 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Li, Xiangqian; Shi, Dayong |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Shandong, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Shandong Univ, State Key Lab Microbial Technol, Qingdao, Shandong, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Shi, Xiaolin,Li, Xiaowei,Li, Xiangqian,et al. Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions[J]. FRONTIERS IN CHEMISTRY,2019,7:10. |
| APA | Shi, Xiaolin,Li, Xiaowei,Li, Xiangqian,&Shi, Dayong.(2019).Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions.FRONTIERS IN CHEMISTRY,7,10. |
| MLA | Shi, Xiaolin,et al."Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions".FRONTIERS IN CHEMISTRY 7(2019):10. |
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