Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| The improved antiviral activities of amino-modified chitosan derivatives on Newcastle virus | |
He, Xiaofei1,2,3; Xing, Ronge1,2,3 ; Liu, Song1,2,3; Qin, Yukun1,2,3; Li, Kecheng1,2,3; Yu, Huahua1,2,3; Li, Pengcheng1,2,3
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| 2019-06-07 | |
| 发表期刊 | DRUG AND CHEMICAL TOXICOLOGY
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| ISSN | 0148-0545 |
| 页码 | 6 |
| 通讯作者 | Xing, Ronge(xingronge@qdio.ac.cn) |
| 摘要 | Chitosan is widely used as a medical material because of its excellent biological activities. However, the low solubility of natural chitosan limited its medicinal activity to some extent. The solubility can be improved by introducing more active groups and lowering molecular weight. Therefore, 6-amine chitosan derivatives were synthesized in this paper since more active groups were introduced to increase the medicinal activity. Those derivatives were characterized by elemental analysis, HPLC, and FT-IR and the antiviral activity was tested by hemagglutination tests. Finally, 6-amine chitosan derivatives improved the antiviral activity, especially after the introduction of bromine ion. When 6-deoxy-6-bromo-N-phthaloyl chitosan was 1 g/L, they reduced the hemagglutination titer of virus to zero. The RT-PCR result showed that the expression level of TNF-alpha and IFN-beta increased significantly, which indicated that the antiviral activity of amino-modified chitosan worked through the stimulation of immune response. |
| 关键词 | 6-Deoxy-6-bromo-N-phthaloyl chitosan antiviral activity Newcastle virus mechanism assumption |
| DOI | 10.1080/01480545.2019.1620264 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Key R&D Program of China[2018YFC0311305] ; Special projects of Foshan science and technology innovation team[2017IT100054] ; National Key R&D Program of China[2018YFC0311305] ; Special projects of Foshan science and technology innovation team[2017IT100054] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy ; Toxicology |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy ; Toxicology |
| WOS记录号 | WOS:000473846600001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/161972 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Xing, Ronge |
| 作者单位 | 1.Chinese Acad Sci, Ctr Ocean Mega Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Shandong, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Shandong, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 通讯作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | He, Xiaofei,Xing, Ronge,Liu, Song,et al. The improved antiviral activities of amino-modified chitosan derivatives on Newcastle virus[J]. DRUG AND CHEMICAL TOXICOLOGY,2019:6. |
| APA | He, Xiaofei.,Xing, Ronge.,Liu, Song.,Qin, Yukun.,Li, Kecheng.,...&Li, Pengcheng.(2019).The improved antiviral activities of amino-modified chitosan derivatives on Newcastle virus.DRUG AND CHEMICAL TOXICOLOGY,6. |
| MLA | He, Xiaofei,et al."The improved antiviral activities of amino-modified chitosan derivatives on Newcastle virus".DRUG AND CHEMICAL TOXICOLOGY (2019):6. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| The improved antivir（589KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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