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The improved antiviral activities of amino-modified chitosan derivatives on Newcastle virus
He, Xiaofei1,2,3; Xing, Ronge1,2,3; Liu, Song1,2,3; Qin, Yukun1,2,3; Li, Kecheng1,2,3; Yu, Huahua1,2,3; Li, Pengcheng1,2,3
2019-06-07
Source PublicationDRUG AND CHEMICAL TOXICOLOGY
ISSN0148-0545
Pages6
Corresponding AuthorXing, Ronge(xingronge@qdio.ac.cn)
AbstractChitosan is widely used as a medical material because of its excellent biological activities. However, the low solubility of natural chitosan limited its medicinal activity to some extent. The solubility can be improved by introducing more active groups and lowering molecular weight. Therefore, 6-amine chitosan derivatives were synthesized in this paper since more active groups were introduced to increase the medicinal activity. Those derivatives were characterized by elemental analysis, HPLC, and FT-IR and the antiviral activity was tested by hemagglutination tests. Finally, 6-amine chitosan derivatives improved the antiviral activity, especially after the introduction of bromine ion. When 6-deoxy-6-bromo-N-phthaloyl chitosan was 1 g/L, they reduced the hemagglutination titer of virus to zero. The RT-PCR result showed that the expression level of TNF-alpha and IFN-beta increased significantly, which indicated that the antiviral activity of amino-modified chitosan worked through the stimulation of immune response.
Keyword6-Deoxy-6-bromo-N-phthaloyl chitosan antiviral activity Newcastle virus mechanism assumption
DOI10.1080/01480545.2019.1620264
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2018YFC0311305] ; Special projects of Foshan science and technology innovation team[2017IT100054]
WOS Research AreaChemistry ; Pharmacology & Pharmacy ; Toxicology
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy ; Toxicology
WOS IDWOS:000473846600001
PublisherTAYLOR & FRANCIS LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/161972
Collection实验海洋生物学重点实验室
Corresponding AuthorXing, Ronge
Affiliation1.Chinese Acad Sci, Ctr Ocean Mega Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Shandong, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Shandong, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
He, Xiaofei,Xing, Ronge,Liu, Song,et al. The improved antiviral activities of amino-modified chitosan derivatives on Newcastle virus[J]. DRUG AND CHEMICAL TOXICOLOGY,2019:6.
APA He, Xiaofei.,Xing, Ronge.,Liu, Song.,Qin, Yukun.,Li, Kecheng.,...&Li, Pengcheng.(2019).The improved antiviral activities of amino-modified chitosan derivatives on Newcastle virus.DRUG AND CHEMICAL TOXICOLOGY,6.
MLA He, Xiaofei,et al."The improved antiviral activities of amino-modified chitosan derivatives on Newcastle virus".DRUG AND CHEMICAL TOXICOLOGY (2019):6.
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