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Thiocladospolides A-D, 12-Membered Macrolides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides MA-299 and Structure Revision of Pandangolide 3
Zhang, Fan-Zhong1,2,3; Li, Xiao-Ming1,2; Yang, Sui-Qun1,2; Meng, Ling-Hong1,2; Wang, Bin-Gui1,2,3
2019-06-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号82期号:6页码:1535-1541
通讯作者Meng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
摘要Four new 12-membered macrolides, thiocladospolides A-D (1-4), each possessing a sulfur substitution at C-2, along with the known congener pandangolide 3 (5) and the possible hydrolysis product seco-patulolide C (6), were isolated and identified from the culture extract of Cladosporium cladosporioides MA-299, an endophytic fungus obtained from the leaves of the mangrove plant Bruguiera gymnorrhiza. Their structures were established by interpretation of the NMR spectroscopic and mass spectrometric data. X-ray crystallographic analysis of compound 1, which represents the first crystal structure described for a sulfur-containing 12-membered macrolide, confirmed its structure and absolute configuration. The proposed sulfur side chain at C-3 in pandangolide 3 (5) was revised to be at C-2 by detailed analysis of the NMR data and by a comparison with data for thiocladospolide A (1). The structures for pandangolides 2 and 4 should also be considered for revisions. The isolated compounds were evaluated for the antimicrobial activities against aquatic bacteria and plant pathogens.
DOI10.1021/acs.jnatprod.8b01091
收录类别SCI
语种英语
资助项目Natural Science Foundation of China[81673351] ; Natural Science Foundation of China[31600267] ; Natural Science Foundation of Shandong Province[ZR2016BQ17] ; Taishan Scholar Project from Shandong Province ; Natural Science Foundation of China[81673351] ; Natural Science Foundation of China[31600267] ; Natural Science Foundation of Shandong Province[ZR2016BQ17] ; Taishan Scholar project from Shandong Province
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000473827300017
出版者AMER CHEMICAL SOC
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/161954
专题实验海洋生物学重点实验室
通讯作者Meng, Ling-Hong; Wang, Bin-Gui
作者单位1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
第一作者单位中国科学院海洋研究所
通讯作者单位中国科学院海洋研究所
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GB/T 7714
Zhang, Fan-Zhong,Li, Xiao-Ming,Yang, Sui-Qun,et al. Thiocladospolides A-D, 12-Membered Macrolides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides MA-299 and Structure Revision of Pandangolide 3[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(6):1535-1541.
APA Zhang, Fan-Zhong,Li, Xiao-Ming,Yang, Sui-Qun,Meng, Ling-Hong,&Wang, Bin-Gui.(2019).Thiocladospolides A-D, 12-Membered Macrolides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides MA-299 and Structure Revision of Pandangolide 3.JOURNAL OF NATURAL PRODUCTS,82(6),1535-1541.
MLA Zhang, Fan-Zhong,et al."Thiocladospolides A-D, 12-Membered Macrolides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides MA-299 and Structure Revision of Pandangolide 3".JOURNAL OF NATURAL PRODUCTS 82.6(2019):1535-1541.
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