IOCAS-IR  > 实验海洋生物学重点实验室
Investigation of the Amide Proton Solvent Exchange Properties of Glycosaminoglycan Oligosaccharides
Green, Andrew R.1; Li, Kecheng1,2,3; Lockard, Blake1; Young, Robert P.1,4; Mueller, Leonard J.1; Larive, Cynthia K.1
2019-06-06
发表期刊JOURNAL OF PHYSICAL CHEMISTRY B
ISSN1520-6106
卷号123期号:22页码:4653-4662
通讯作者Larive, Cynthia K.(clarive@ucr.edu)
摘要One-dimensional H-1 NMR experiments were conducted for aqueous solutions of glycosaminoglycan oligosaccharides to measure the amide proton temperature coefficients and activation energy barriers for solvent exchange and evaluate the effect of pH on the solvent exchange properties. A library of mono- and oligosaccharides was prepared by enzymatic depolymerization of amide-containing polysaccharides and by chemical modification of heparin and heparan sulfate saccharides including members that contain a 3-O-sulfated glucosamine residue. The systematic evaluation of this saccharide library facilitated assessment of the effects of structural characteristics, such as size, sulfation number and site, and glycosidic linkage, on amide proton solvent exchange rates. Charge repulsion by neighboring negatively charged sulfate and carboxylate groups was found to have a significant impact on the catalysis of amide proton solvent exchange by hydroxide. This observation leads to the conclusion that solvent exchange rates must be interpreted within the context of a given chemical environment. On their own, slow exchange rates do not conclusively establish the involvement of a labile proton in a hydrogen bond, and additional supporting experimental evidence such as reduced temperature coefficients is required.
DOI10.1021/acs.jpcb.9b01794
收录类别SCI
语种英语
资助项目NSF[CHE-1626673] ; NIH[R01GM097569] ; China Scholarship Council[201504910405] ; NSF[CHE-1626673] ; NIH[R01GM097569] ; China Scholarship Council[201504910405]
WOS研究方向Chemistry
WOS类目Chemistry, Physical
WOS记录号WOS:000470938100005
出版者AMER CHEMICAL SOC
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/161835
专题实验海洋生物学重点实验室
通讯作者Larive, Cynthia K.
作者单位1.Univ Calif Riverside, Dept Chem, Riverside, CA 92501 USA
2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Megasci, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Shandong, Peoples R China
4.Pacific Northwest Natl Lab, Environm Mol Sci Lab, Richland, WA 99352 USA
推荐引用方式
GB/T 7714
Green, Andrew R.,Li, Kecheng,Lockard, Blake,et al. Investigation of the Amide Proton Solvent Exchange Properties of Glycosaminoglycan Oligosaccharides[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2019,123(22):4653-4662.
APA Green, Andrew R.,Li, Kecheng,Lockard, Blake,Young, Robert P.,Mueller, Leonard J.,&Larive, Cynthia K..(2019).Investigation of the Amide Proton Solvent Exchange Properties of Glycosaminoglycan Oligosaccharides.JOURNAL OF PHYSICAL CHEMISTRY B,123(22),4653-4662.
MLA Green, Andrew R.,et al."Investigation of the Amide Proton Solvent Exchange Properties of Glycosaminoglycan Oligosaccharides".JOURNAL OF PHYSICAL CHEMISTRY B 123.22(2019):4653-4662.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Investigation of the(2121KB)期刊论文出版稿限制开放CC BY-NC-SA浏览
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Green, Andrew R.]的文章
[Li, Kecheng]的文章
[Lockard, Blake]的文章
百度学术
百度学术中相似的文章
[Green, Andrew R.]的文章
[Li, Kecheng]的文章
[Lockard, Blake]的文章
必应学术
必应学术中相似的文章
[Green, Andrew R.]的文章
[Li, Kecheng]的文章
[Lockard, Blake]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Investigation of the Amide Proton Solvent Exchange Properties of Glycosaminoglycan Oligosaccharides.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。