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Potential Mechanisms of Action of Curcumin for Cancer Prevention: Focus on Cellular Signaling Pathways and miRNAs
Wang, Man1; Jiang, Shuai2; Zhou, Li3; Yu, Fei1; Ding, Han1; Li, Peifeng1; Zhou, Meng4; Wang, Kun1
Corresponding AuthorWang, Man( ; Zhou, Meng( ; Wang, Kun(
AbstractDespite significant progressions in treatment modalities over the last decade, either cancer incidence or mortality is continuously on the rise throughout the world. Current anticancer agents display limited efficacy, accompanied by severe side effects. In order to improve therapeutic outcomes in patients with cancer, it is crucial to identify novel, highly efficacious pharmacological agents. Curcumin, a hydrophobic polyphenol extracted from turmeric, has gained increasing attention due to its powerful anticancer properties. Curcumin can inhibit the growth, invasion and metastasis of various cancers. The anticancer mechanisms of curcumin have been extensively studied. The anticancer effects of curcumin are mainly mediated through its regulation of multiple cellular signaling pathways, including Wnt/beta-catenin, PI3K/Akt, JAK/STAT, MAPK, p53 and NF-kappa B signaling pathways. Moreover, curcumin also orchestrates the expression and activity of oncogenic and tumor-suppressive miRNAs. In this review, we summarized the regulation of these signaling pathways by curcumin in different cancers. We also discussed the modulatory function of curcumin in the downregulation of oncogenic miRNAs and the upregulation of tumor-suppressive miRNAs. An in-depth understanding of the anticancer mechanisms of curcumin will be helpful for developing this promising compound as a therapeutic agent in clinical management of cancer.
Keywordcurcumin cancer signaling pathways miRNAs
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81701991] ; Applied Basic Research Programs of Qingdao, China[17-1-1-59-jch]
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS SubjectBiochemistry & Molecular Biology ; Biology
WOS IDWOS:000471070800008
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Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorWang, Man; Zhou, Meng; Wang, Kun
Affiliation1.Qingdao Univ, Med Coll, Inst Translat Med, Dengzhou Rd 38, Qingdao 266021, Shandong, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China
3.Wuhan Univ, Anim Biosafety Level Lab 3, Ctr Anim Expt, Sch Med, Wuhan 430071, Hubei, Peoples R China
4.Shandong Univ Qingdao, Qilu Hosp, Dept Dermatol, Qingdao 266000, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Man,Jiang, Shuai,Zhou, Li,et al. Potential Mechanisms of Action of Curcumin for Cancer Prevention: Focus on Cellular Signaling Pathways and miRNAs[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2019,15(6):1200-1214.
APA Wang, Man.,Jiang, Shuai.,Zhou, Li.,Yu, Fei.,Ding, Han.,...&Wang, Kun.(2019).Potential Mechanisms of Action of Curcumin for Cancer Prevention: Focus on Cellular Signaling Pathways and miRNAs.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,15(6),1200-1214.
MLA Wang, Man,et al."Potential Mechanisms of Action of Curcumin for Cancer Prevention: Focus on Cellular Signaling Pathways and miRNAs".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 15.6(2019):1200-1214.
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