Potential Mechanisms of Action of Curcumin for Cancer Prevention: Focus on Cellular Signaling Pathways and miRNAs

doi:10.7150/ijbs.33710

IOCAS-IR > 实验海洋生物学重点实验室

	Potential Mechanisms of Action of Curcumin for Cancer Prevention: Focus on Cellular Signaling Pathways and miRNAs
	Wang, Man 1; Jiang, Shuai 2; Zhou, Li 3; Yu, Fei 1; Ding, Han 1; Li, Peifeng 1; Zhou, Meng 4; Wang, Kun 1
	2019
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN	1449-2288
卷号	15 期号:6 页码:1200-1214
通讯作者	Wang, Man(wangman@qdu.edu.cn) ; Zhou, Meng(zhoumeng666@foxmail.com) ; Wang, Kun(wangk696@163.com)
摘要	Despite significant progressions in treatment modalities over the last decade, either cancer incidence or mortality is continuously on the rise throughout the world. Current anticancer agents display limited efficacy, accompanied by severe side effects. In order to improve therapeutic outcomes in patients with cancer, it is crucial to identify novel, highly efficacious pharmacological agents. Curcumin, a hydrophobic polyphenol extracted from turmeric, has gained increasing attention due to its powerful anticancer properties. Curcumin can inhibit the growth, invasion and metastasis of various cancers. The anticancer mechanisms of curcumin have been extensively studied. The anticancer effects of curcumin are mainly mediated through its regulation of multiple cellular signaling pathways, including Wnt/beta-catenin, PI3K/Akt, JAK/STAT, MAPK, p53 and NF-kappa B signaling pathways. Moreover, curcumin also orchestrates the expression and activity of oncogenic and tumor-suppressive miRNAs. In this review, we summarized the regulation of these signaling pathways by curcumin in different cancers. We also discussed the modulatory function of curcumin in the downregulation of oncogenic miRNAs and the upregulation of tumor-suppressive miRNAs. An in-depth understanding of the anticancer mechanisms of curcumin will be helpful for developing this promising compound as a therapeutic agent in clinical management of cancer.
关键词	curcumin cancer signaling pathways miRNAs
DOI	10.7150/ijbs.33710
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81701991] ; Applied Basic Research Programs of Qingdao, China[17-1-1-59-jch] ; National Natural Science Foundation of China[81701991] ; Applied Basic Research Programs of Qingdao, China[17-1-1-59-jch]
WOS研究方向	Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS类目	Biochemistry & Molecular Biology ; Biology
WOS记录号	WOS:000471070800008
出版者	IVYSPRING INT PUBL
引用统计	被引频次：108[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/161823
专题	实验海洋生物学重点实验室
通讯作者	Wang, Man; Zhou, Meng; Wang, Kun
作者单位	1.Qingdao Univ, Med Coll, Inst Translat Med, Dengzhou Rd 38, Qingdao 266021, Shandong, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China 3.Wuhan Univ, Anim Biosafety Level Lab 3, Ctr Anim Expt, Sch Med, Wuhan 430071, Hubei, Peoples R China 4.Shandong Univ Qingdao, Qilu Hosp, Dept Dermatol, Qingdao 266000, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Wang, Man,Jiang, Shuai,Zhou, Li,et al. Potential Mechanisms of Action of Curcumin for Cancer Prevention: Focus on Cellular Signaling Pathways and miRNAs[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2019,15(6):1200-1214.
APA	Wang, Man.,Jiang, Shuai.,Zhou, Li.,Yu, Fei.,Ding, Han.,...&Wang, Kun.(2019).Potential Mechanisms of Action of Curcumin for Cancer Prevention: Focus on Cellular Signaling Pathways and miRNAs.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,15(6),1200-1214.
MLA	Wang, Man,et al."Potential Mechanisms of Action of Curcumin for Cancer Prevention: Focus on Cellular Signaling Pathways and miRNAs".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 15.6(2019):1200-1214.