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Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides
Zhang, Fan-Zhong1,2,3; Li, Xiao-Ming1,2; Li, Xin1,2; Yang, Sui-Qun1,2; Meng, Ling-Hong1,2; Wang, Bin-Gui1,2,3
2019-05-01
发表期刊MARINE DRUGS
ISSN1660-3397
卷号17期号:5页码:13
通讯作者Meng, Ling-Hong(m8545303@163.com) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
摘要Five new polyketides, namely, 5R-hydroxyrecifeiolide (1), 5S-hydroxyrecifeiolide (2), ent-cladospolide F (3), cladospolide G (4), and cladospolide H (5), along with two known compounds (6 and 7), were isolated from the endophytic fungal strain Cladosporium cladosporioides MA-299 that was obtained from the leaves of the mangrove plant Bruguiera gymnorrhiza. The structures of these compounds were established by extensive analysis of 1D/2D NMR data, mass spectrometric data, ECDs and optical rotations, and modified Mosher's method. The structures of 3 and 6 were confirmed by single-crystal X-ray diffraction analysis and this is the first time for reporting the crystal structures of these two compounds. All of the isolated compounds were examined for antimicrobial activities against human and aquatic bacteria and plant pathogenic fungi as well as enzymatic inhibitory activities against acetylcholinesterase. Compounds 1-4, 6, and 7 exhibited antimicrobial activity against some of the tested strains with MIC values ranging from 1.0 to 64 g/mL, while 3 exhibited enzymatic inhibitory activity against acetylcholinesterase with the IC50 value of 40.26 M.
关键词mangrove plant endophytic fungus Cladosporium cladosporioides polyketides antimicrobial activity acetylcholinesterase enzymatic inhibitory activity
DOI10.3390/md17050296
收录类别SCI
语种英语
资助项目Natural Science Foundation of China[81673351] ; Natural Science Foundation of China[31600267] ; Natural Science Foundation of Shandong Province, China[ZR2016BQ17] ; Taishan Scholar Project from Shandong Province ; Natural Science Foundation of China[81673351] ; Natural Science Foundation of China[31600267] ; Natural Science Foundation of Shandong Province, China[ZR2016BQ17] ; Taishan Scholar project from Shandong province
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal
WOS记录号WOS:000470964600049
出版者MDPI
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/161820
专题实验海洋生物学重点实验室
通讯作者Meng, Ling-Hong; Wang, Bin-Gui
作者单位1.Chinese Acad Sci, Key Lab Expt Marine Biol, Ctr Ocean Mega Sci, Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
第一作者单位中国科学院海洋研究所
通讯作者单位中国科学院海洋研究所
推荐引用方式
GB/T 7714
Zhang, Fan-Zhong,Li, Xiao-Ming,Li, Xin,et al. Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides[J]. MARINE DRUGS,2019,17(5):13.
APA Zhang, Fan-Zhong,Li, Xiao-Ming,Li, Xin,Yang, Sui-Qun,Meng, Ling-Hong,&Wang, Bin-Gui.(2019).Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides.MARINE DRUGS,17(5),13.
MLA Zhang, Fan-Zhong,et al."Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides".MARINE DRUGS 17.5(2019):13.
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