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Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides
Zhang, Fan-Zhong1,2,3; Li, Xiao-Ming1,2; Li, Xin1,2; Yang, Sui-Qun1,2; Meng, Ling-Hong1,2; Wang, Bin-Gui1,2,3
2019-05-01
Source PublicationMARINE DRUGS
ISSN1660-3397
Volume17Issue:5Pages:13
Corresponding AuthorMeng, Ling-Hong(m8545303@163.com) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
AbstractFive new polyketides, namely, 5R-hydroxyrecifeiolide (1), 5S-hydroxyrecifeiolide (2), ent-cladospolide F (3), cladospolide G (4), and cladospolide H (5), along with two known compounds (6 and 7), were isolated from the endophytic fungal strain Cladosporium cladosporioides MA-299 that was obtained from the leaves of the mangrove plant Bruguiera gymnorrhiza. The structures of these compounds were established by extensive analysis of 1D/2D NMR data, mass spectrometric data, ECDs and optical rotations, and modified Mosher's method. The structures of 3 and 6 were confirmed by single-crystal X-ray diffraction analysis and this is the first time for reporting the crystal structures of these two compounds. All of the isolated compounds were examined for antimicrobial activities against human and aquatic bacteria and plant pathogenic fungi as well as enzymatic inhibitory activities against acetylcholinesterase. Compounds 1-4, 6, and 7 exhibited antimicrobial activity against some of the tested strains with MIC values ranging from 1.0 to 64 g/mL, while 3 exhibited enzymatic inhibitory activity against acetylcholinesterase with the IC50 value of 40.26 M.
Keywordmangrove plant endophytic fungus Cladosporium cladosporioides polyketides antimicrobial activity acetylcholinesterase enzymatic inhibitory activity
DOI10.3390/md17050296
Indexed BySCI
Language英语
Funding ProjectNatural Science Foundation of China[81673351] ; Natural Science Foundation of China[31600267] ; Natural Science Foundation of Shandong Province, China[ZR2016BQ17] ; Taishan Scholar project from Shandong province
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000470964600049
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/161820
Collection实验海洋生物学重点实验室
Corresponding AuthorMeng, Ling-Hong; Wang, Bin-Gui
Affiliation1.Chinese Acad Sci, Key Lab Expt Marine Biol, Ctr Ocean Mega Sci, Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Fan-Zhong,Li, Xiao-Ming,Li, Xin,et al. Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides[J]. MARINE DRUGS,2019,17(5):13.
APA Zhang, Fan-Zhong,Li, Xiao-Ming,Li, Xin,Yang, Sui-Qun,Meng, Ling-Hong,&Wang, Bin-Gui.(2019).Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides.MARINE DRUGS,17(5),13.
MLA Zhang, Fan-Zhong,et al."Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides".MARINE DRUGS 17.5(2019):13.
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