Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Laurendecumallenes A-B and laurendecumenynes A-B, halogenated nonterpenoid C-15-Acetogenins from the marine red alga Laurencia decumbens | |
Ji, Nai-Yun; Li, Xiao-Ming; Li, Ke; Wang, Bin-Gui; Wang, BG, Chinese Acad Sci, Inst Oceanog, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China | |
2007-09-01 | |
发表期刊 | JOURNAL OF NATURAL PRODUCTS |
ISSN | 0163-3864 |
卷号 | 70期号:9页码:1499-1502 |
文章类型 | Article |
摘要 | Four new halogenated nonterpenoid C-15-acetogenins, 4:7,6:13-bisepoxy-9,10-diol-1,12-dibromopentadeca-1,2-diene (1, laurendecumallene A), 4:7,6:12-bisepoxy-9,10-diol-1,13-dibromopentadeca-1,2-diene (2, laurendecumallene 13), (3Z)-6:10,7:13-bisepoxy-12-bromo-9-hydroperoxylpentadeca-3-en-1-yne (3, laurendecumenyne A), and (3Z)-6:10,9:13-bisepoxy-12-bromo-7-chloropentadeca-3-en-1-yne (4, laurendecumenyne 13), together with one known halogenated C-15-acetogenin elatenyne (5) were isolated and identified from the organic extract of the marine red alga Laurencia decumbens. Their structures and relative stereochemistry were established by means of spectroscopic analysis including UV, IR, high-resolution electrospray ionization mass spectrometry (HRESIMS), and ID and 2D NMR techniques. All these metabolites were submitted for the cytotoxic assay against tumor cell line A549 (human lung adenocarcinoma), but all of them were found inactive (IC50 > 10 mu g/mL).; Four new halogenated nonterpenoid C-15-acetogenins, 4:7,6:13-bisepoxy-9,10-diol-1,12-dibromopentadeca-1,2-diene (1, laurendecumallene A), 4:7,6:12-bisepoxy-9,10-diol-1,13-dibromopentadeca-1,2-diene (2, laurendecumallene 13), (3Z)-6:10,7:13-bisepoxy-12-bromo-9-hydroperoxylpentadeca-3-en-1-yne (3, laurendecumenyne A), and (3Z)-6:10,9:13-bisepoxy-12-bromo-7-chloropentadeca-3-en-1-yne (4, laurendecumenyne 13), together with one known halogenated C-15-acetogenin elatenyne (5) were isolated and identified from the organic extract of the marine red alga Laurencia decumbens. Their structures and relative stereochemistry were established by means of spectroscopic analysis including UV, IR, high-resolution electrospray ionization mass spectrometry (HRESIMS), and ID and 2D NMR techniques. All these metabolites were submitted for the cytotoxic assay against tumor cell line A549 (human lung adenocarcinoma), but all of them were found inactive (IC50 > 10 mu g/mL). |
关键词 | Natural-products Metabolites |
学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
DOI | 10.1021/np0701172 |
URL | 查看原文 |
收录类别 | SCI ; IC |
语种 | 英语 |
WOS记录号 | WOS:000249871200022 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/1617 |
专题 | 实验海洋生物学重点实验室 |
通讯作者 | Wang, BG, Chinese Acad Sci, Inst Oceanog, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China |
作者单位 | 1.Chinese Acad Sci, Inst Oceanog, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Ji, Nai-Yun,Li, Xiao-Ming,Li, Ke,et al. Laurendecumallenes A-B and laurendecumenynes A-B, halogenated nonterpenoid C-15-Acetogenins from the marine red alga Laurencia decumbens[J]. JOURNAL OF NATURAL PRODUCTS,2007,70(9):1499-1502. |
APA | Ji, Nai-Yun,Li, Xiao-Ming,Li, Ke,Wang, Bin-Gui,&Wang, BG, Chinese Acad Sci, Inst Oceanog, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.(2007).Laurendecumallenes A-B and laurendecumenynes A-B, halogenated nonterpenoid C-15-Acetogenins from the marine red alga Laurencia decumbens.JOURNAL OF NATURAL PRODUCTS,70(9),1499-1502. |
MLA | Ji, Nai-Yun,et al."Laurendecumallenes A-B and laurendecumenynes A-B, halogenated nonterpenoid C-15-Acetogenins from the marine red alga Laurencia decumbens".JOURNAL OF NATURAL PRODUCTS 70.9(2007):1499-1502. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Ji-2007-Laurendecuma(95KB) | 限制开放 | -- | 浏览 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论