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Laurendecumallenes A-B and laurendecumenynes A-B, halogenated nonterpenoid C-15-Acetogenins from the marine red alga Laurencia decumbens
Ji, Nai-Yun; Li, Xiao-Ming; Li, Ke; Wang, Bin-Gui; Wang, BG, Chinese Acad Sci, Inst Oceanog, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2007-09-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号70期号:9页码:1499-1502
文章类型Article
摘要Four new halogenated nonterpenoid C-15-acetogenins, 4:7,6:13-bisepoxy-9,10-diol-1,12-dibromopentadeca-1,2-diene (1, laurendecumallene A), 4:7,6:12-bisepoxy-9,10-diol-1,13-dibromopentadeca-1,2-diene (2, laurendecumallene 13), (3Z)-6:10,7:13-bisepoxy-12-bromo-9-hydroperoxylpentadeca-3-en-1-yne (3, laurendecumenyne A), and (3Z)-6:10,9:13-bisepoxy-12-bromo-7-chloropentadeca-3-en-1-yne (4, laurendecumenyne 13), together with one known halogenated C-15-acetogenin elatenyne (5) were isolated and identified from the organic extract of the marine red alga Laurencia decumbens. Their structures and relative stereochemistry were established by means of spectroscopic analysis including UV, IR, high-resolution electrospray ionization mass spectrometry (HRESIMS), and ID and 2D NMR techniques. All these metabolites were submitted for the cytotoxic assay against tumor cell line A549 (human lung adenocarcinoma), but all of them were found inactive (IC50 > 10 mu g/mL).; Four new halogenated nonterpenoid C-15-acetogenins, 4:7,6:13-bisepoxy-9,10-diol-1,12-dibromopentadeca-1,2-diene (1, laurendecumallene A), 4:7,6:12-bisepoxy-9,10-diol-1,13-dibromopentadeca-1,2-diene (2, laurendecumallene 13), (3Z)-6:10,7:13-bisepoxy-12-bromo-9-hydroperoxylpentadeca-3-en-1-yne (3, laurendecumenyne A), and (3Z)-6:10,9:13-bisepoxy-12-bromo-7-chloropentadeca-3-en-1-yne (4, laurendecumenyne 13), together with one known halogenated C-15-acetogenin elatenyne (5) were isolated and identified from the organic extract of the marine red alga Laurencia decumbens. Their structures and relative stereochemistry were established by means of spectroscopic analysis including UV, IR, high-resolution electrospray ionization mass spectrometry (HRESIMS), and ID and 2D NMR techniques. All these metabolites were submitted for the cytotoxic assay against tumor cell line A549 (human lung adenocarcinoma), but all of them were found inactive (IC50 > 10 mu g/mL).
关键词Natural-products Metabolites
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np0701172
URL查看原文
收录类别SCI ; IC
语种英语
WOS记录号WOS:000249871200022
引用统计
被引频次:55[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/1617
专题实验海洋生物学重点实验室
通讯作者Wang, BG, Chinese Acad Sci, Inst Oceanog, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
作者单位1.Chinese Acad Sci, Inst Oceanog, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
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Ji, Nai-Yun,Li, Xiao-Ming,Li, Ke,et al. Laurendecumallenes A-B and laurendecumenynes A-B, halogenated nonterpenoid C-15-Acetogenins from the marine red alga Laurencia decumbens[J]. JOURNAL OF NATURAL PRODUCTS,2007,70(9):1499-1502.
APA Ji, Nai-Yun,Li, Xiao-Ming,Li, Ke,Wang, Bin-Gui,&Wang, BG, Chinese Acad Sci, Inst Oceanog, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.(2007).Laurendecumallenes A-B and laurendecumenynes A-B, halogenated nonterpenoid C-15-Acetogenins from the marine red alga Laurencia decumbens.JOURNAL OF NATURAL PRODUCTS,70(9),1499-1502.
MLA Ji, Nai-Yun,et al."Laurendecumallenes A-B and laurendecumenynes A-B, halogenated nonterpenoid C-15-Acetogenins from the marine red alga Laurencia decumbens".JOURNAL OF NATURAL PRODUCTS 70.9(2007):1499-1502.
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