Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery

doi:10.1007/s00343-019-8127-8

IOCAS-IR

	Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery
	Yu Weiting 1; Zhang Demeng 2,4; Liu Xiudong 3; Wang Yunhong 3; Tong Jun 3; Zhang Mengxue 4; Ma Xiaojun 5
	2019-05-01
发表期刊	JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN	2096-5508
卷号	37 期号:3 页码:855-862
通讯作者	Yu Weiting(yuwt@dicp.ac.cn) ; Zhang Demeng(zdm@bmscn.com)
摘要	To overcome the fast or burst release of hydrophilic drugs from hydrophilic alginate-based carriers, hydrophobic molecule (vinyl acetate, VAc) was grafted on alginate (Alg), which was further used to prepare drug carriers. Amphiphilic Alg-g-PVAc hydrogel beads were firstly prepared by emulsification/internal gelation technique for the loading of bovine serum albumin (BSA). Then, chitosan was coated on the surface of beads to form novel amphiphilic Alg-g-PVAc/chitosan (Alg-g-PVAc/CS) microcapsules. The BSA-loading amphiphilic Alg-g-PVAc/chitosan (Alg-g-PVAc/CS) microcapsules display similar morphology and size to the hydrophilic alginate/chitosan (AC) microcapsules. However, the drug loading and loading efficiency of BSA in Alg-g-PVAc/CS microcapsules are higher, and the release rate of BSA from Alg-g-PVAc/CS microcapsules is slower. The results demonstrate that the introduction of hydrophobic PVAc on alginate can effectively help retard the release of BSA, and the higher degree of substitution is, the slower the release rate is. In addition, the complex membrane can also be adjusted to delay the release of BSA. As a whole, amphiphilic sodium alginate-vinyl acetate/CS microparticles could be developed for macromolecular drug delivery.
关键词	hydrophobic modification sodium alginate-vinyl acetate amphiphilic Alg-g-PVAc/chitosan microcapsules drug delivery
DOI	10.1007/s00343-019-8127-8
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[21276033] ; Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances[SKL-BASS1711] ; Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances[SKL-BASS1707] ; National Undergraduates Innovation and Entrepreneurship Training Program of China[201711258000001] ; National Natural Science Foundation of China[21276033] ; Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances[SKL-BASS1711] ; Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances[SKL-BASS1707] ; National Undergraduates Innovation and Entrepreneurship Training Program of China[201711258000001]
WOS研究方向	Marine & Freshwater Biology ; Oceanography
WOS类目	Limnology ; Oceanography
WOS记录号	WOS:000469401600009
出版者	SCIENCE PRESS
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/161569
专题	中国科学院海洋研究所
通讯作者	Yu Weiting; Zhang Demeng
作者单位	1.Dalian Univ, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China 3.Dalian Univ, Coll Environm & Chem Engn, Dalian Econ Technol Dev Zone, Dalian 116622, Peoples R China 4.Qingdao Brightmoon Seaweed Grp Co Ltd, State Key Lab Bioact Seaweed Subst, Qingdao 266400, Shandong, Peoples R China 5.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Yu Weiting,Zhang Demeng,Liu Xiudong,et al. Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery[J]. JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2019,37(3):855-862.
APA	Yu Weiting.,Zhang Demeng.,Liu Xiudong.,Wang Yunhong.,Tong Jun.,...&Ma Xiaojun.(2019).Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,37(3),855-862.
MLA	Yu Weiting,et al."Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery".JOURNAL OF OCEANOLOGY AND LIMNOLOGY 37.3(2019):855-862.

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