Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery
Yu Weiting1; Zhang Demeng2,4; Liu Xiudong3; Wang Yunhong3; Tong Jun3; Zhang Mengxue4; Ma Xiaojun5
Corresponding AuthorYu Weiting( ; Zhang Demeng(
AbstractTo overcome the fast or burst release of hydrophilic drugs from hydrophilic alginate-based carriers, hydrophobic molecule (vinyl acetate, VAc) was grafted on alginate (Alg), which was further used to prepare drug carriers. Amphiphilic Alg-g-PVAc hydrogel beads were firstly prepared by emulsification/internal gelation technique for the loading of bovine serum albumin (BSA). Then, chitosan was coated on the surface of beads to form novel amphiphilic Alg-g-PVAc/chitosan (Alg-g-PVAc/CS) microcapsules. The BSA-loading amphiphilic Alg-g-PVAc/chitosan (Alg-g-PVAc/CS) microcapsules display similar morphology and size to the hydrophilic alginate/chitosan (AC) microcapsules. However, the drug loading and loading efficiency of BSA in Alg-g-PVAc/CS microcapsules are higher, and the release rate of BSA from Alg-g-PVAc/CS microcapsules is slower. The results demonstrate that the introduction of hydrophobic PVAc on alginate can effectively help retard the release of BSA, and the higher degree of substitution is, the slower the release rate is. In addition, the complex membrane can also be adjusted to delay the release of BSA. As a whole, amphiphilic sodium alginate-vinyl acetate/CS microparticles could be developed for macromolecular drug delivery.
Keywordhydrophobic modification sodium alginate-vinyl acetate amphiphilic Alg-g-PVAc/chitosan microcapsules drug delivery
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[21276033] ; Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances[SKL-BASS1711] ; Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances[SKL-BASS1707] ; National Undergraduates Innovation and Entrepreneurship Training Program of China[201711258000001]
WOS Research AreaMarine & Freshwater Biology ; Oceanography
WOS SubjectLimnology ; Oceanography
WOS IDWOS:000469401600009
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorYu Weiting; Zhang Demeng
Affiliation1.Dalian Univ, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China
3.Dalian Univ, Coll Environm & Chem Engn, Dalian Econ Technol Dev Zone, Dalian 116622, Peoples R China
4.Qingdao Brightmoon Seaweed Grp Co Ltd, State Key Lab Bioact Seaweed Subst, Qingdao 266400, Shandong, Peoples R China
5.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Yu Weiting,Zhang Demeng,Liu Xiudong,et al. Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery[J]. JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2019,37(3):855-862.
APA Yu Weiting.,Zhang Demeng.,Liu Xiudong.,Wang Yunhong.,Tong Jun.,...&Ma Xiaojun.(2019).Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,37(3),855-862.
MLA Yu Weiting,et al."Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery".JOURNAL OF OCEANOLOGY AND LIMNOLOGY 37.3(2019):855-862.
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