A Novel Candidate Gene Associated With Body Weight in the Pacific White Shrimp Litopenaeus vannamei

doi:10.3389/fgene.2019.00520

IOCAS-IR > 实验海洋生物学重点实验室

	A Novel Candidate Gene Associated With Body Weight in the Pacific White Shrimp Litopenaeus vannamei
	Wang, Quanchao1 ; Yu, Yang1,2 ; Zhang, Qian1,3 ; Zhang, Xiaojun 1,2; Yuan, Jianbo 1,2; Huang, Hao 4; Xiang, Jianhai1,2,5 ; Li, Fuhua 1,2,5
	2019-05-31
发表期刊	FRONTIERS IN GENETICS
ISSN	1664-8021
卷号	10 页码:8
通讯作者	Li, Fuhua(fhli@qdio.ac.cn)
摘要	Improvements of growth traits are always the focus in selective breeding programs for the Pacific white shrimp Litopenaeus vannamei (L. vannamei). Identification of growth-related genes or markers can contribute to the application of modern breeding technologies, and thus accelerate the genetic improvement of growth traits. The aim of this study was to identify the genes and molecular markers associated with the growth traits of L. vannamei. A population of 200 individuals was genotyped using 2b-RAD techniques for genome-wide linkage disequilibrium (LD) analysis and genome-wide association study (GWAS). The results showed that the LD decayed fast in the studied population, which suggest that it is feasible to fine map the growth-related genes with GWAS in L. vannamei. One gene designated as LvSRC, encoding the class C scavenger receptor (SRC), was identified as a growth-related candidate gene by GWAS. Further targeted sequencing of the candidate gene in another population of 322 shrimps revealed that several non-synonymous mutations within LvSRC were significantly associated with the body weight (P < 0.01), and the most significant marker (SRC_24) located in the candidate gene could explain 13% of phenotypic variance. The current results provide not only molecular markers for genetic improvement in L. vannamei, but also new insights for understanding the growth regulation mechanism in penaeid shrimp.
关键词	penaeid shrimp growth traits GWAS candidate gene class C scavenger receptor
DOI	10.3389/fgene.2019.00520
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2018YFD0901301] ; National Natural Science Foundation of China[31830100] ; China Agriculture Research system-48 (CARS-48) ; National Key R&D Program of China[2018YFD0901301] ; National Natural Science Foundation of China[31830100] ; China Agriculture Research System-48 (CARS-48)
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000470234400001
出版者	FRONTIERS MEDIA SA
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/161560
专题	实验海洋生物学重点实验室
通讯作者	Li, Fuhua
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Shandong, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Hainan Grand Suntop Ocean Breeding Co Ltd, Wenchang, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Shandong, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Wang, Quanchao,Yu, Yang,Zhang, Qian,et al. A Novel Candidate Gene Associated With Body Weight in the Pacific White Shrimp Litopenaeus vannamei[J]. FRONTIERS IN GENETICS,2019,10:8.
APA	Wang, Quanchao.,Yu, Yang.,Zhang, Qian.,Zhang, Xiaojun.,Yuan, Jianbo.,...&Li, Fuhua.(2019).A Novel Candidate Gene Associated With Body Weight in the Pacific White Shrimp Litopenaeus vannamei.FRONTIERS IN GENETICS,10,8.
MLA	Wang, Quanchao,et al."A Novel Candidate Gene Associated With Body Weight in the Pacific White Shrimp Litopenaeus vannamei".FRONTIERS IN GENETICS 10(2019):8.

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A Novel Candidate Ge（1385KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览