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The first identification of a malectin gene (CfMal) in scallop Chlamys farreri: sequence features and expression profiles
Wang, M. Q.1,3; Wang, B. J.1; Liu, M.1; Jiang, K. Y.1; Wang, L.1,2,4
2019
发表期刊ISJ-INVERTEBRATE SURVIVAL JOURNAL
ISSN1824-307X
卷号16页码:25-33
通讯作者Wang, L.(wanglei@qdio.ac.cn)
摘要Malectin is a newly discovered lectin of the endoplasmic reticulum (ER) that might be involved in innate immunity. Information about the roles of malectin in innate immunity is scarce. In the present study, a novel malectin gene (designated as CfMal) from the Zhikong scallop Chlamys farreri was identified and characterized. Sequence features, tissue distribution, and temporal expression profiles were investigated to infer the potential functions of CfMal in innate immunity. The complete cDNA sequence of CfMal comprised 1,111 bp and contained an open reading frame of 909 bp, which encoded 302 amino acid residues. A malectin domain and a transmembrane region were identified in the predicted protein sequence. CfMal mRNA transcripts were detectable in hemocytes, muscle, mantle, gill, hepatopancreas, and gonads. CfMal expression was highest in hemocytes. Stimulation with Vibrio splendidus increased CfMal expression in hemocytes, gill, and hepatopancreas. The mRNA transcripts of CfMal and three related genes, including binding immunoglobulin protein, heat shock protein 90 kDa beta member 1 protein and ER degradation enhancing alpha-mannosidase like protein 1, increased in scallop hemocytes during an artificial ER-stress. Our results indicate that CfMal might not only be involved in ER-stress, but may also play a role in innate immunity of scallops.
关键词Chlamys farreri innate immunity malectin
收录类别SCI
语种英语
资助项目National Natural Science Foundation of China[U1706209] ; Aoshan Innovation Project in Science and Technology from National Laboratory for Marine Science and Technology[2016ASKJ07] ; Science and Technology Service Network Plan (STS) Major Deployment Project[KFZD-SW-106] ; STS Regional Centre Project (Fujian) from the Chinese Academy of Sciences ; National Natural Science Foundation of China[U1706209] ; Aoshan Innovation Project in Science and Technology from National Laboratory for Marine Science and Technology[2016ASKJ07] ; Science and Technology Service Network Plan (STS) Major Deployment Project[KFZD-SW-106] ; STS Regional Centre Project (Fujian) from the Chinese Academy of Sciences
WOS研究方向Immunology ; Zoology
WOS类目Immunology ; Zoology
WOS记录号WOS:000466031500002
出版者INVERTEBRATE SURVIVAL JOURNAL
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/161362
专题实验海洋生物学重点实验室
通讯作者Wang, L.
作者单位1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China
3.Natl Lab Marine Sci & Technol, Res Platform Marine Mol Biotechnol, Qingdao 266237, Shandong, Peoples R China
4.Chinese Acad Sci, CAS Ctr Ocean Mega Sci, Qingdao 266400, Shandong, Peoples R China
第一作者单位中国科学院海洋研究所
通讯作者单位中国科学院海洋研究所
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Wang, M. Q.,Wang, B. J.,Liu, M.,et al. The first identification of a malectin gene (CfMal) in scallop Chlamys farreri: sequence features and expression profiles[J]. ISJ-INVERTEBRATE SURVIVAL JOURNAL,2019,16:25-33.
APA Wang, M. Q.,Wang, B. J.,Liu, M.,Jiang, K. Y.,&Wang, L..(2019).The first identification of a malectin gene (CfMal) in scallop Chlamys farreri: sequence features and expression profiles.ISJ-INVERTEBRATE SURVIVAL JOURNAL,16,25-33.
MLA Wang, M. Q.,et al."The first identification of a malectin gene (CfMal) in scallop Chlamys farreri: sequence features and expression profiles".ISJ-INVERTEBRATE SURVIVAL JOURNAL 16(2019):25-33.
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