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Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway
Xu, Kuo1; Guo, Chuanlong1,2; Meng, Jie1,3; Tian, Haiying4; Guo, Shuju1; Shi, Dayong1,5
2019-04-01
Source PublicationMARINE DRUGS
ISSN1660-3397
Volume17Issue:4Pages:11
Corresponding AuthorGuo, Shuju(guoshuju@qdio.ac.cn) ; Shi, Dayong(shidayong@qdio.ac.cn)
AbstractA study on the secondary metabolites of Aspergillus sp. XNM-4, which was derived from marine algae Leathesia nana (Chordariaceae), led to the identification of one previously undescribed (1) and seventeen known compounds (2-18). Their planar structures were established by extensive spectroscopic analyses, while the stereochemical assignments were defined by electronic circular dichroism (ECD) calculations. The biological activities of the compounds were assessed on five human cancer cell lines (PANC-1, A549, MDA-MB-231, Caco-2, and SK-OV-3), and one human normal cell line (HL-7702) using an MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide] assay. Among them, the dimeric naphthopyrones 7, 10 and 12 exhibited potent cytotoxicity. Further mechanism studies showed that 12 induced apoptosis, arrested the cell cycle at the G0/G1 phase in the PANC-1 cells, caused morphological changes and generated ROS; and it induces PANC-1 cells apoptosis via ROS-mediated PI3K/Akt signaling pathway.
KeywordAspergillus naphthopyrones cytotoxicity endophytic fungus Leathesia nana
DOI10.3390/md17040207
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81803375] ; National Postdoctoral Program for Innovative Talents[BX201700247] ; China Postdoctoral Science Foundation[2018M630804] ; Natural Science Foundation of Shandong Province[ZR2016DQ07] ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722]
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000467307100014
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/161356
Collection实验海洋生物学重点实验室
Corresponding AuthorGuo, Shuju; Shi, Dayong
Affiliation1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Univ Sci & Technol, Coll Chem Engn, Dept Pharm, Qingdao 266042, Shandong, Peoples R China
3.Qingdao Agr Univ, Coll Resources & Environm, Qingdao 266109, Shandong, Peoples R China
4.China Tobacco Henan Ind Co Ltd, Technol Ctr, Zhengzhou 450000, Henan, Peoples R China
5.Shandong Univ, Sch Life Sci, State Key Lab Microbial Technol, 72 Binhai Rd, Qingdao 266237, Shandong, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Xu, Kuo,Guo, Chuanlong,Meng, Jie,et al. Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway[J]. MARINE DRUGS,2019,17(4):11.
APA Xu, Kuo,Guo, Chuanlong,Meng, Jie,Tian, Haiying,Guo, Shuju,&Shi, Dayong.(2019).Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway.MARINE DRUGS,17(4),11.
MLA Xu, Kuo,et al."Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway".MARINE DRUGS 17.4(2019):11.
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