IOCAS-IR  > 实验海洋生物学重点实验室
Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway
Xu, Kuo1; Guo, Chuanlong1,2; Meng, Jie1,3; Tian, Haiying4; Guo, Shuju1; Shi, Dayong1,5
2019-04-01
发表期刊MARINE DRUGS
ISSN1660-3397
卷号17期号:4页码:11
通讯作者Guo, Shuju(guoshuju@qdio.ac.cn) ; Shi, Dayong(shidayong@qdio.ac.cn)
摘要A study on the secondary metabolites of Aspergillus sp. XNM-4, which was derived from marine algae Leathesia nana (Chordariaceae), led to the identification of one previously undescribed (1) and seventeen known compounds (2-18). Their planar structures were established by extensive spectroscopic analyses, while the stereochemical assignments were defined by electronic circular dichroism (ECD) calculations. The biological activities of the compounds were assessed on five human cancer cell lines (PANC-1, A549, MDA-MB-231, Caco-2, and SK-OV-3), and one human normal cell line (HL-7702) using an MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide] assay. Among them, the dimeric naphthopyrones 7, 10 and 12 exhibited potent cytotoxicity. Further mechanism studies showed that 12 induced apoptosis, arrested the cell cycle at the G0/G1 phase in the PANC-1 cells, caused morphological changes and generated ROS; and it induces PANC-1 cells apoptosis via ROS-mediated PI3K/Akt signaling pathway.
关键词Aspergillus naphthopyrones cytotoxicity endophytic fungus Leathesia nana
DOI10.3390/md17040207
收录类别SCI
语种英语
资助项目National Natural Science Foundation of China[81803375] ; National Postdoctoral Program for Innovative Talents[BX201700247] ; China Postdoctoral Science Foundation[2018M630804] ; Natural Science Foundation of Shandong Province[ZR2016DQ07] ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722] ; National Natural Science Foundation of China[81803375] ; National Postdoctoral Program for Innovative Talents[BX201700247] ; China Postdoctoral Science Foundation[2018M630804] ; Natural Science Foundation of Shandong Province[ZR2016DQ07] ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722]
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal
WOS记录号WOS:000467307100014
出版者MDPI
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/161356
专题实验海洋生物学重点实验室
通讯作者Guo, Shuju; Shi, Dayong
作者单位1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Univ Sci & Technol, Coll Chem Engn, Dept Pharm, Qingdao 266042, Shandong, Peoples R China
3.Qingdao Agr Univ, Coll Resources & Environm, Qingdao 266109, Shandong, Peoples R China
4.China Tobacco Henan Ind Co Ltd, Technol Ctr, Zhengzhou 450000, Henan, Peoples R China
5.Shandong Univ, Sch Life Sci, State Key Lab Microbial Technol, 72 Binhai Rd, Qingdao 266237, Shandong, Peoples R China
第一作者单位中国科学院海洋研究所
通讯作者单位中国科学院海洋研究所
推荐引用方式
GB/T 7714
Xu, Kuo,Guo, Chuanlong,Meng, Jie,et al. Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway[J]. MARINE DRUGS,2019,17(4):11.
APA Xu, Kuo,Guo, Chuanlong,Meng, Jie,Tian, Haiying,Guo, Shuju,&Shi, Dayong.(2019).Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway.MARINE DRUGS,17(4),11.
MLA Xu, Kuo,et al."Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway".MARINE DRUGS 17.4(2019):11.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
marinedrugs-17-00207(3680KB)期刊论文出版稿限制开放CC BY-NC-SA浏览
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xu, Kuo]的文章
[Guo, Chuanlong]的文章
[Meng, Jie]的文章
百度学术
百度学术中相似的文章
[Xu, Kuo]的文章
[Guo, Chuanlong]的文章
[Meng, Jie]的文章
必应学术
必应学术中相似的文章
[Xu, Kuo]的文章
[Guo, Chuanlong]的文章
[Meng, Jie]的文章
相关权益政策
暂无数据
收藏/分享
文件名: marinedrugs-17-00207-v2.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。