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Noncoding RNAs as Molecular Targets of Resveratrol Underlying Its Anticancer Effects
Wang, Man1; Jiang, Shuai2; Yu, Fei1; Zhou, Li3; Wang, Kun1
Corresponding AuthorWang, Man( ; Wang, Kun(
AbstractCancer is a significant disease burden worldwide. Chemotherapy is the mainstay of cancer treatment. Clinically used chemotherapeutic agents may elicit severe side effects. Remarkably, most of cancer cells develop chemoresistance after a period of treatment. Therefore, it is imperative to seek more effective agents without side effects. In recent years, increasing research efforts have attempted to identify natural agents that may be used alone or in combination with traditional therapeutics for cancer management. Resveratrol is a natural polyphenolic phytoalexin that can be found in various foods including blueberries, peanuts, and red wine. As a natural food ingredient, resveratrol possesses antioxidant, anti-inflammatory, and cardioprotective properties. Moreover, resveratrol exhibited promising effects in suppressing the initiation and progression of cancers. Noncoding RNAs (ncRNAs) have been universally accepted as vital regulators in cancer pathogenesis. The modulation of miRNAs and lncRNAs by resveratrol has been described. Thus, the mechanism involving the domination of ncRNA function is one of the keys to understand the anticancer effects of resveratrol. In this review, we focus on the antagonistic effects of resveratrol on cancer progression through regulation of miRNAs and lncRNAs. We also discuss the potential application of resveratrol in cancer management.
Keywordresveratrol cancer miRNA incRNA anticancer effect
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81701991] ; Applied Basic Research Programs of Qingdao, China[17-1-1-59-jch]
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:000466988400001
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Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorWang, Man; Wang, Kun
Affiliation1.Qingdao Univ, Med Coll, Inst Translat Med, Dengzhou Rd 38, Qingdao 266021, Shandong, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China
3.Wuhan Univ, Sch Med, Ctr Expt Anim, Anim Biosafety Level Lab 3, Wuhan 430071, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Wang, Man,Jiang, Shuai,Yu, Fei,et al. Noncoding RNAs as Molecular Targets of Resveratrol Underlying Its Anticancer Effects[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(17):4709-4719.
APA Wang, Man,Jiang, Shuai,Yu, Fei,Zhou, Li,&Wang, Kun.(2019).Noncoding RNAs as Molecular Targets of Resveratrol Underlying Its Anticancer Effects.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(17),4709-4719.
MLA Wang, Man,et al."Noncoding RNAs as Molecular Targets of Resveratrol Underlying Its Anticancer Effects".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.17(2019):4709-4719.
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