Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Inhibitory Effect of Metalloproteinase Inhibitors on Skin Cell Inflammation Induced by Jellyfish Nemopilema nomurai Nematocyst Venom | |
Li, Aoyu1,2,3,4; Yu, Huahua1,2,3 ; Li, Rongfeng1,2,3; Liu, Song1,2,3; Xing, Ronge1,2,3; Li, Pengcheng1,2,3
| |
| 2019-03-10 | |
| 发表期刊 | TOXINS
 |
| ISSN | 2072-6651 |
| 卷号 | 11期号:3页码:12 |
| 通讯作者 | Yu, Huahua(yuhuahua@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn) |
| 摘要 | Jellyfish envenomations result in extensive dermatological symptoms, clinically named as jellyfish dermatitis, which can seriously affect the daily activities and physical health of people. Inflammatory response accompanies the whole process of jellyfish dermatitis and the complexity of jellyfish venom components makes it difficult to treat jellyfish dermatitis symptoms effectively. Moreover, inhibiting inflammation is essential for the treatment of jellyfish stings and exploring the main components of jellyfish venom that cause inflammation is an urgent research area. In this study, the inhibitory effects of matrix metalloproteinase (MMP) inhibitors for venom-induced inflammation were explored at a cellular level. The expression of the three inflammatory factors, IL-6, TNF-alpha and MCP-1 in two skin cell lines, human keratinocyte cells (HaCaT) and human embryonic skin fibroblasts cells (CCC-ESF-1), at the cellular level, after treatment with the inhibitors of jellyfish Nemopilema nomurai (N. nomurai) nematocyst venom (NnNV-I), were determined. The results showed that inhibitors of MMP can significantly reduce the toxic effects of jellyfish Nemopilema nomurai nematocyst venom (NnNV) to skin cells. The expression levels of the three inflammatory factors IL-6, MCP-1, and TNF-alpha in the cells were also significantly decreased, indicating that MMPs in jellyfish venom are probably vital factors leading to jellyfish dermatitis. This study is beneficial in the prevention and treatment of jellyfish stings. |
| 关键词 | Nemopilema nomurai nematocyst venom (NnNV) jellyfish dermatitis matrix metalloproteinases (MMPs) inflammatory factors skin cells |
| DOI | 10.3390/toxins11030156 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[41776163] ; National Key RD Plan[2017YFE0111100-04] ; Key Research and Development Plan of Shandong Province[2017GHY215003] ; Qingdao Science and Technology Project[17-3-3-21-nsh] ; National Natural Science Foundation of China[41776163] ; National Key RD Plan[2017YFE0111100-04] ; Key Research and Development Plan of Shandong Province[2017GHY215003] ; Qingdao Science and Technology Project[17-3-3-21-nsh] |
| WOS研究方向 | Food Science & Technology ; Toxicology |
| WOS类目 | Food Science & Technology ; Toxicology |
| WOS记录号 | WOS:000464475100001 |
| 出版者 | MDPI |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/161165 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Yu, Huahua; Li, Pengcheng |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Biol Prod, Qingdao 266237, Shandong, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China 4.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 通讯作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Li, Aoyu,Yu, Huahua,Li, Rongfeng,et al. Inhibitory Effect of Metalloproteinase Inhibitors on Skin Cell Inflammation Induced by Jellyfish Nemopilema nomurai Nematocyst Venom[J]. TOXINS,2019,11(3):12. |
| APA | Li, Aoyu,Yu, Huahua,Li, Rongfeng,Liu, Song,Xing, Ronge,&Li, Pengcheng.(2019).Inhibitory Effect of Metalloproteinase Inhibitors on Skin Cell Inflammation Induced by Jellyfish Nemopilema nomurai Nematocyst Venom.TOXINS,11(3),12. |
| MLA | Li, Aoyu,et al."Inhibitory Effect of Metalloproteinase Inhibitors on Skin Cell Inflammation Induced by Jellyfish Nemopilema nomurai Nematocyst Venom".TOXINS 11.3(2019):12. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Inhibitory Effect of（1461KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论