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Responses of antioxidant defenses in the clam Mactra veneriformis to 2,2 ',4, 4 '-tetrabromodiphenyl ether exposure
Dong, Shihang1; Yang, Yanyan2; Cheng, Bo3; Ren, Chuanbo2; Zhang, Huawei2; Xu, Hua4; Zhu, Na1; Wang, Wansheng1; Dang, Yongjian1; Li, Mingzhu1; Chen, Jun1; Wang, Kai1; Zhang, Libin5; Fang, Yan1
2019-03-01
Source PublicationCOMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
ISSN1532-0456
Volume217Pages:98-105
Corresponding AuthorFang, Yan(fly12689@163.com)
AbstractAntioxidant enzymes play essential roles against oxidative stress caused by 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), which is ubiquitous in marine environment and organisms. However, research on antioxidant responses to BDE-47 in marine bivalves is scarce. In this study, we identified the full-length cDNA of catalase (CAT), and glutathione peroxidase (GPx) in the clam Mactra veneriformis. Subsequently, the responses of CAT, GPx, and copper, zinc-superoxide dismutase (Cu, Zn-SOD) were investigated in the clams exposed to 0.1, 1, and 10 mu g/L BDE-47 for 7 days, and then depurated in natural seawater for 3 days. MvCAT and MvGPx contained conserved sequences. The deduced amino acid sequences shared high similarity with CATs and GPxs in other mollusks. M. veneriformis accumulated BDE-47 in a dose-dependent manner and eliminated BDE-47 poorly. BDE-47 induced a time- and dose-dependent increase of malondialdehyde content. Both the dose and the duration had significant effect on mRNA expressions and activities of the three antioxidants. Cu, Zn-SOD responded to BDE-47 earlier than CAT and GPx. The antioxidant responses could recover after depuration. These results suggested that M. veneriformis could accumulate BDE-47 efficiently. Antioxidant enzymes were triggered to counter the oxidative stress generated by BDE-47. Cu, Zn-SOD acted as the first defense against oxidative stress, while CAT and GPx intervened later. This study is therefore helpful in understanding the antioxidant responses to PBDEs in marine bivalves.
KeywordCatalase Glutathione peroxidase Superoxide dismutase 2,2 ',4,4 '-Tetrabromodiphenyl ether Malondialdehyde Mactra veneriformis
DOI10.1016/j.cbpc.2018.12.003
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[41206120] ; National Natural Science Foundation of China[31502191] ; National Natural Science Foundation of China[31502173] ; Development Plan of Science and Technology in Yantai[2011062] ; Ludong University Research Funding[210-32040301] ; Innovative Project of Undergraduate[201710451328] ; Innovative Project of Undergraduate[171133]
WOS Research AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology
WOS IDWOS:000463848100011
PublisherELSEVIER SCIENCE INC
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/161147
Collection中国科学院海洋研究所
Corresponding AuthorFang, Yan
Affiliation1.Ludong Univ, Sch Agr, Yantai 264025, Peoples R China
2.Shandong Marine Resource & Environm Res Inst, Shandong Prov Key Lab Restorat Marine Ecol, Yantai 264006, Peoples R China
3.Chinese Acad Fishery Sci, Aquat Prod Qual & Stand Res Ctr, Beijing 100141, Peoples R China
4.Yantai Environm Monitoring Ctr Stn, Yantai 264000, Peoples R China
5.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Dong, Shihang,Yang, Yanyan,Cheng, Bo,et al. Responses of antioxidant defenses in the clam Mactra veneriformis to 2,2 ',4, 4 '-tetrabromodiphenyl ether exposure[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,2019,217:98-105.
APA Dong, Shihang.,Yang, Yanyan.,Cheng, Bo.,Ren, Chuanbo.,Zhang, Huawei.,...&Fang, Yan.(2019).Responses of antioxidant defenses in the clam Mactra veneriformis to 2,2 ',4, 4 '-tetrabromodiphenyl ether exposure.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,217,98-105.
MLA Dong, Shihang,et al."Responses of antioxidant defenses in the clam Mactra veneriformis to 2,2 ',4, 4 '-tetrabromodiphenyl ether exposure".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 217(2019):98-105.
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