Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base | |
Shi, Xiaolin1,2,4; Li, Xiaowei1,2,4 ; Ma, Lina1,2,4; Shi, Dayong1,2,3,4
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| 2019-03-01 | |
| Source Publication | CATALYSTS
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| ISSN | 2073-4344 |
| Volume | 9Issue:3Pages:14 |
| Corresponding Author | Shi, Dayong(shidayong@qdio.ac.cn) |
| Abstract | This paper offers an efficient copper-catalyzed oxidative trifluoromethylation of indoles with low-cost CF3SO2Na via C-H activation. Notably, the use of a base is crucial for the trifluoromethylation of indoles. This reaction proceeds efficiently in good to excellent yields and is tolerance of a broad range of functional groups. Furthermore, melatonin, a medicine for sleep disorders, is converted to its 2-CF3 analogue in 68% yield. Studies of possible reaction pathways suggest that this reaction proceeds through a radical process. |
| Keyword | Cu(II) catalyst Langlois reagent trifluoromethylation indole radical reaction |
| DOI | 10.3390/catal9030278 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[81773586] ; National Natural Science Foundation of China[81703354] ; Key research and development project of Shandong province[2016GSF201193] ; Key research and development project of Shandong province[2016ZDJS07A13] ; Key research and development project of Shandong province[2016GSF115002] ; Key research and development project of Shandong province[2016GSF115009] ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-DQC014] ; Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Program of Chinese Academy of Sciences[ZSTH-026] ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722] ; National Program for Support of Top-notch Young Professionals ; Taishan scholar Youth Project of Shandong province |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Physical |
| WOS ID | WOS:000465012800058 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/161096 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Shi, Dayong |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266000, Shandong, Peoples R China 3.Shandong Univ, State Key Lab Microbial Technol, 72 Binhai Rd, Qingdao 266237, Shandong, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Shi, Xiaolin,Li, Xiaowei,Ma, Lina,et al. Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base[J]. CATALYSTS,2019,9(3):14. |
| APA | Shi, Xiaolin,Li, Xiaowei,Ma, Lina,&Shi, Dayong.(2019).Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base.CATALYSTS,9(3),14. |
| MLA | Shi, Xiaolin,et al."Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base".CATALYSTS 9.3(2019):14. |
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