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Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base
Shi, Xiaolin1,2,4; Li, Xiaowei1,2,4; Ma, Lina1,2,4; Shi, Dayong1,2,3,4
2019-03-01
Source PublicationCATALYSTS
ISSN2073-4344
Volume9Issue:3Pages:14
Corresponding AuthorShi, Dayong(shidayong@qdio.ac.cn)
AbstractThis paper offers an efficient copper-catalyzed oxidative trifluoromethylation of indoles with low-cost CF3SO2Na via C-H activation. Notably, the use of a base is crucial for the trifluoromethylation of indoles. This reaction proceeds efficiently in good to excellent yields and is tolerance of a broad range of functional groups. Furthermore, melatonin, a medicine for sleep disorders, is converted to its 2-CF3 analogue in 68% yield. Studies of possible reaction pathways suggest that this reaction proceeds through a radical process.
KeywordCu(II) catalyst Langlois reagent trifluoromethylation indole radical reaction
DOI10.3390/catal9030278
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[81773586] ; National Natural Science Foundation of China[81703354] ; Key research and development project of Shandong province[2016GSF201193] ; Key research and development project of Shandong province[2016ZDJS07A13] ; Key research and development project of Shandong province[2016GSF115002] ; Key research and development project of Shandong province[2016GSF115009] ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-DQC014] ; Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Program of Chinese Academy of Sciences[ZSTH-026] ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722] ; National Program for Support of Top-notch Young Professionals ; Taishan scholar Youth Project of Shandong province
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
WOS IDWOS:000465012800058
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/161096
Collection实验海洋生物学重点实验室
Corresponding AuthorShi, Dayong
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266000, Shandong, Peoples R China
3.Shandong Univ, State Key Lab Microbial Technol, 72 Binhai Rd, Qingdao 266237, Shandong, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Shi, Xiaolin,Li, Xiaowei,Ma, Lina,et al. Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base[J]. CATALYSTS,2019,9(3):14.
APA Shi, Xiaolin,Li, Xiaowei,Ma, Lina,&Shi, Dayong.(2019).Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base.CATALYSTS,9(3),14.
MLA Shi, Xiaolin,et al."Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base".CATALYSTS 9.3(2019):14.
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