Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base

doi:10.3390/catal9030278

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	Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base
	Shi, Xiaolin 1,2,4; Li, Xiaowei1,2,4 ; Ma, Lina 1,2,4; Shi, Dayong 1,2,3,4
	2019-03-01
Source Publication	CATALYSTS
ISSN	2073-4344
Volume	9 Issue:3 Pages:14
Corresponding Author	Shi, Dayong(shidayong@qdio.ac.cn)
Abstract	This paper offers an efficient copper-catalyzed oxidative trifluoromethylation of indoles with low-cost CF3SO2Na via C-H activation. Notably, the use of a base is crucial for the trifluoromethylation of indoles. This reaction proceeds efficiently in good to excellent yields and is tolerance of a broad range of functional groups. Furthermore, melatonin, a medicine for sleep disorders, is converted to its 2-CF3 analogue in 68% yield. Studies of possible reaction pathways suggest that this reaction proceeds through a radical process.
Keyword	Cu(II) catalyst Langlois reagent trifluoromethylation indole radical reaction
DOI	10.3390/catal9030278
Indexed By	SCI
Language	英语
Funding Project	National Natural Science Foundation of China[81773586] ; National Natural Science Foundation of China[81703354] ; Key research and development project of Shandong province[2016GSF201193] ; Key research and development project of Shandong province[2016ZDJS07A13] ; Key research and development project of Shandong province[2016GSF115002] ; Key research and development project of Shandong province[2016GSF115009] ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-DQC014] ; Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Program of Chinese Academy of Sciences[ZSTH-026] ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722] ; National Program for Support of Top-notch Young Professionals ; Taishan scholar Youth Project of Shandong province ; National Natural Science Foundation of China[81773586] ; National Natural Science Foundation of China[81703354] ; Key research and development project of Shandong province[2016GSF201193] ; Key research and development project of Shandong province[2016ZDJS07A13] ; Key research and development project of Shandong province[2016GSF115002] ; Key research and development project of Shandong province[2016GSF115009] ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-DQC014] ; Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Program of Chinese Academy of Sciences[ZSTH-026] ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722] ; National Program for Support of Top-notch Young Professionals ; Taishan scholar Youth Project of Shandong province
WOS Research Area	Chemistry
WOS Subject	Chemistry, Physical
WOS ID	WOS:000465012800058
Publisher	MDPI
Citation statistics	Cited Times:9[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.qdio.ac.cn/handle/337002/161096
Collection	实验海洋生物学重点实验室
Corresponding Author	Shi, Dayong
Affiliation	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266000, Shandong, Peoples R China 3.Shandong Univ, State Key Lab Microbial Technol, 72 Binhai Rd, Qingdao 266237, Shandong, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author Affilication	Institute of Oceanology, Chinese Academy of Sciences
Corresponding Author Affilication	Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation GB/T 7714	Shi, Xiaolin,Li, Xiaowei,Ma, Lina,et al. Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base[J]. CATALYSTS,2019,9(3):14.
APA	Shi, Xiaolin,Li, Xiaowei,Ma, Lina,&Shi, Dayong.(2019).Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base.CATALYSTS,9(3),14.
MLA	Shi, Xiaolin,et al."Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base".CATALYSTS 9.3(2019):14.

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