| Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base |
| Shi, Xiaolin1,2,4; Li, Xiaowei1,2,4 ; Ma, Lina1,2,4; Shi, Dayong1,2,3,4
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| 2019-03-01
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Source Publication | CATALYSTS
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ISSN | 2073-4344
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Volume | 9Issue:3Pages:14 |
Corresponding Author | Shi, Dayong(shidayong@qdio.ac.cn)
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Abstract | This paper offers an efficient copper-catalyzed oxidative trifluoromethylation of indoles with low-cost CF3SO2Na via C-H activation. Notably, the use of a base is crucial for the trifluoromethylation of indoles. This reaction proceeds efficiently in good to excellent yields and is tolerance of a broad range of functional groups. Furthermore, melatonin, a medicine for sleep disorders, is converted to its 2-CF3 analogue in 68% yield. Studies of possible reaction pathways suggest that this reaction proceeds through a radical process. |
Keyword | Cu(II) catalyst
Langlois reagent
trifluoromethylation
indole
radical reaction
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DOI | 10.3390/catal9030278
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Indexed By | SCI
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Language | 英语
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Funding Project | National Natural Science Foundation of China[81773586]
; National Natural Science Foundation of China[81703354]
; Key research and development project of Shandong province[2016GSF201193]
; Key research and development project of Shandong province[2016ZDJS07A13]
; Key research and development project of Shandong province[2016GSF115002]
; Key research and development project of Shandong province[2016GSF115009]
; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-DQC014]
; Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Program of Chinese Academy of Sciences[ZSTH-026]
; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722]
; National Program for Support of Top-notch Young Professionals
; Taishan scholar Youth Project of Shandong province
; National Natural Science Foundation of China[81773586]
; National Natural Science Foundation of China[81703354]
; Key research and development project of Shandong province[2016GSF201193]
; Key research and development project of Shandong province[2016ZDJS07A13]
; Key research and development project of Shandong province[2016GSF115002]
; Key research and development project of Shandong province[2016GSF115009]
; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-DQC014]
; Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Program of Chinese Academy of Sciences[ZSTH-026]
; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722]
; National Program for Support of Top-notch Young Professionals
; Taishan scholar Youth Project of Shandong province
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WOS Research Area | Chemistry
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WOS Subject | Chemistry, Physical
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WOS ID | WOS:000465012800058
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Publisher | MDPI
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Citation statistics |
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Document Type | 期刊论文
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Identifier | http://ir.qdio.ac.cn/handle/337002/161096
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Collection | 实验海洋生物学重点实验室
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Corresponding Author | Shi, Dayong |
Affiliation | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266000, Shandong, Peoples R China 3.Shandong Univ, State Key Lab Microbial Technol, 72 Binhai Rd, Qingdao 266237, Shandong, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences
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Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences
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Recommended Citation GB/T 7714 |
Shi, Xiaolin,Li, Xiaowei,Ma, Lina,et al. Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base[J]. CATALYSTS,2019,9(3):14.
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APA |
Shi, Xiaolin,Li, Xiaowei,Ma, Lina,&Shi, Dayong.(2019).Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base.CATALYSTS,9(3),14.
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MLA |
Shi, Xiaolin,et al."Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base".CATALYSTS 9.3(2019):14.
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