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CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs
Luo, Jiao1,2; Jiang, Bo2; Li, Chao2; Jia, Xiaoling2; Shi, Dayong3
2019
Source PublicationMARINE DRUGS
ISSN1660-3397
Volume17Issue:1Pages:15
Corresponding AuthorShi, Dayong(shidayong@sdu.edu.cn)
AbstractRNA-binding proteins (RBPs) lie at the center of posttranscriptional regulation and the dysregulation of RBPs contributes to diabetes. Therefore, the modulation of RBPs is anticipated to become a potential therapeutic approach to diabetes. CYC27 is a synthetic derivative of marine bromophenol BDB, which is isolated from red alga Rhodomela confervoides. In this study, we found that CYC27 significantly lowered the blood glucose levels of diabetic BKS db mice. Moreover, CYC27 effectively ameliorated dyslipidemia in BKS db mice by reducing their total serum cholesterol (TC) and triglyceride (TG) levels. Furthermore, CYC27 was an insulin-sensitizing agent with increased insulin-stimulated phosphorylation of insulin receptors and relevant downstream factors. Finally, to systemically study the mechanisms of CYC27, label-free quantitative phosphoproteomic analysis was performed to investigate global changes in phosphorylation. Enriched GO annotation showed that most regulated phosphoproteins were related to RNA splicing and RNA processing. Enriched KEGG analysis showed that a spliceosome-associated pathway was the predominant pathway after CYC27 treatment. Protein-protein interaction (PPI) analysis showed that CYC27 modulated the process of mRNA splicing via phosphorylation of the relevant RBPs, including upregulated Cstf3 and Srrt. Our results suggested that CYC27 treatment exerted promising anti-diabetic effects by sensitizing the insulin signaling pathways and modulating RNA splicing-associated RBPs.
Keywordbrominated organic compounds hypoglycemic activity insulin-sensitizing effect RBPs RNA splicing
DOI10.3390/md17010049
Indexed BySCI
Language英语
Funding ProjectKey Research and Development Project of the Shandong Province[2018GSF118208] ; Key Research and Development Project of the Shandong Province[2016ZDJS07A13] ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-DQC014] ; National Program for Support of Top-notch Young Professionals ; Fund of Taishan Scholar Project ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722] ; NSFC-Shandong Joint Fund[U1706213] ; Qingdao Marine Biomedical Science and Technology Innovation Center Project[2017-CXZX01-1-1] ; Qingdao Marine Biomedical Science and Technology Innovation Center Project[2017-CXZX01-3-9]
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000458053200049
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/160871
Collection实验海洋生物学重点实验室
Corresponding AuthorShi, Dayong
Affiliation1.Qingdao Univ, Sch Publ Hlth, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
3.Shandong Univ, State Key Lab Microbial Technol, Jinan 250100, Shandong, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Luo, Jiao,Jiang, Bo,Li, Chao,et al. CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs[J]. MARINE DRUGS,2019,17(1):15.
APA Luo, Jiao,Jiang, Bo,Li, Chao,Jia, Xiaoling,&Shi, Dayong.(2019).CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs.MARINE DRUGS,17(1),15.
MLA Luo, Jiao,et al."CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs".MARINE DRUGS 17.1(2019):15.
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