Metabolome responses of the sea cucumber Apostichopus japonicus to multiple environmental stresses: Heat and hypoxia

doi:10.1016/j.marpolbul.2018.11.063

	Metabolome responses of the sea cucumber Apostichopus japonicus to multiple environmental stresses: Heat and hypoxia
	Huo, Da 1,2,3,4; Sun, Lina 1,2,4; Zhang, Libin 1,2,4; Ru, Xiaoshang 1,2,3,4; Liu, Shilin 1,2,4; Yang, Hongsheng1,2,4
	2019
发表期刊	MARINE POLLUTION BULLETIN
ISSN	0025-326X
卷号	138 页码:407-420
通讯作者	Sun, Lina(sunlina@qdio.ac.cn) ; Yang, Hongsheng(hshyang@ms.qdio.ac.cn)
摘要	Economically important marine organisms face severe environmental challenges, such as high temperature and low dissolved oxygen, from global climate change. Adverse environmental factors impact the survival and growth of economically important marine organisms, thereby negatively influencing the aquaculture industry. However, little is known about the responses of sea cucumbers to combined environmental co-stressors till now. In this study, ultra-performance liquid chromatography (UPLC) was utilized to obtain metabolic profiles of sea cucumbers. Changes in the concentrations of 84, 68, and 417 metabolites related to the responses of sea cucumbers to heat (26 degrees C), hypoxia (2 mg/L) and the combined stress, respectively, were observed and analyzed. Representative biomarkers were discussed in detail, including deltaline, fusarin C, halichondrin B and rapanone. The concentration of metabolites involved in the regulation of energy metabolism, including amino acid, carbohydrate and lipid metabolism were significantly changed, and the tricarboxylic acid (TCA)-cycle was significantly altered under heat plus hypoxia. We interpreted these changes partly as an adaptation mechanism in response to environmental stress. Based on the decreased accumulation of glutamine, we hypothesized that heat stress is the main factor that interferes with the process of glutamic acid-glutamine metabolism. The present study showed that combined environmental stressors have a more extensive impact on the metabolites of the respiratory tree in sea cucumbers than single stress. These results would facilitate further development of the sea cucumber as an echinoderm model to study mechanisms of response to adverse environments, as well as to help advance knowledge of the adaptation of marine organisms to global climate change.
关键词	Sea cucumber Thermal Anoxia Metabolomics UPLC Echinoderm
DOI	10.1016/j.marpolbul.2018.11.063
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[41776161] ; National Natural Science Foundation of China[41776162] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U16060404] ; Agricultural Seed Project of Shandong Province[2016LZGC032] ; Qingdao Applied Basic Research Program[17-1-1-49-JCH] ; Creative Team Project of the Laboratory for Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology[LMEES-CTSP-2018-1] ; Taishan Scholars Program (Distinguished Taishan Scholars) ; National Natural Science Foundation of China[41776161] ; National Natural Science Foundation of China[41776162] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U16060404] ; Agricultural Seed Project of Shandong Province[2016LZGC032] ; Qingdao Applied Basic Research Program[17-1-1-49-JCH] ; Creative Team Project of the Laboratory for Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology[LMEES-CTSP-2018-1] ; Taishan Scholars Program (Distinguished Taishan Scholars)
WOS研究方向	Environmental Sciences & Ecology ; Marine & Freshwater Biology
WOS类目	Environmental Sciences ; Marine & Freshwater Biology
WOS记录号	WOS:000457512500049
出版者	PERGAMON-ELSEVIER SCIENCE LTD
引用统计	被引频次：53[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/160850
专题	海洋生态与环境科学重点实验室
通讯作者	Sun, Lina; Yang, Hongsheng
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所; 中国科学院海洋大科学研究中心
通讯作者单位	中国科学院海洋研究所; 中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Huo, Da,Sun, Lina,Zhang, Libin,et al. Metabolome responses of the sea cucumber Apostichopus japonicus to multiple environmental stresses: Heat and hypoxia[J]. MARINE POLLUTION BULLETIN,2019,138:407-420.
APA	Huo, Da,Sun, Lina,Zhang, Libin,Ru, Xiaoshang,Liu, Shilin,&Yang, Hongsheng.(2019).Metabolome responses of the sea cucumber Apostichopus japonicus to multiple environmental stresses: Heat and hypoxia.MARINE POLLUTION BULLETIN,138,407-420.
MLA	Huo, Da,et al."Metabolome responses of the sea cucumber Apostichopus japonicus to multiple environmental stresses: Heat and hypoxia".MARINE POLLUTION BULLETIN 138(2019):407-420.

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