IOCAS-IR  > 海洋生态与环境科学重点实验室
Metabolome responses of the sea cucumber Apostichopus japonicus to multiple environmental stresses: Heat and hypoxia
Huo, Da1,2,3,4; Sun, Lina1,2,4; Zhang, Libin1,2,4; Ru, Xiaoshang1,2,3,4; Liu, Shilin1,2,4; Yang, Hongsheng1,2,4
2019
Source PublicationMARINE POLLUTION BULLETIN
ISSN0025-326X
Volume138Pages:407-420
Corresponding AuthorSun, Lina(sunlina@qdio.ac.cn) ; Yang, Hongsheng(hshyang@ms.qdio.ac.cn)
AbstractEconomically important marine organisms face severe environmental challenges, such as high temperature and low dissolved oxygen, from global climate change. Adverse environmental factors impact the survival and growth of economically important marine organisms, thereby negatively influencing the aquaculture industry. However, little is known about the responses of sea cucumbers to combined environmental co-stressors till now. In this study, ultra-performance liquid chromatography (UPLC) was utilized to obtain metabolic profiles of sea cucumbers. Changes in the concentrations of 84, 68, and 417 metabolites related to the responses of sea cucumbers to heat (26 degrees C), hypoxia (2 mg/L) and the combined stress, respectively, were observed and analyzed. Representative biomarkers were discussed in detail, including deltaline, fusarin C, halichondrin B and rapanone. The concentration of metabolites involved in the regulation of energy metabolism, including amino acid, carbohydrate and lipid metabolism were significantly changed, and the tricarboxylic acid (TCA)-cycle was significantly altered under heat plus hypoxia. We interpreted these changes partly as an adaptation mechanism in response to environmental stress. Based on the decreased accumulation of glutamine, we hypothesized that heat stress is the main factor that interferes with the process of glutamic acid-glutamine metabolism. The present study showed that combined environmental stressors have a more extensive impact on the metabolites of the respiratory tree in sea cucumbers than single stress. These results would facilitate further development of the sea cucumber as an echinoderm model to study mechanisms of response to adverse environments, as well as to help advance knowledge of the adaptation of marine organisms to global climate change.
KeywordSea cucumber Thermal Anoxia Metabolomics UPLC Echinoderm
DOI10.1016/j.marpolbul.2018.11.063
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[41776161] ; National Natural Science Foundation of China[41776162] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U16060404] ; Agricultural Seed Project of Shandong Province[2016LZGC032] ; Qingdao Applied Basic Research Program[17-1-1-49-JCH] ; Creative Team Project of the Laboratory for Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology[LMEES-CTSP-2018-1] ; Taishan Scholars Program (Distinguished Taishan Scholars)
WOS Research AreaEnvironmental Sciences & Ecology ; Marine & Freshwater Biology
WOS SubjectEnvironmental Sciences ; Marine & Freshwater Biology
WOS IDWOS:000457512500049
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/160850
Collection海洋生态与环境科学重点实验室
Corresponding AuthorSun, Lina; Yang, Hongsheng
Affiliation1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Huo, Da,Sun, Lina,Zhang, Libin,et al. Metabolome responses of the sea cucumber Apostichopus japonicus to multiple environmental stresses: Heat and hypoxia[J]. MARINE POLLUTION BULLETIN,2019,138:407-420.
APA Huo, Da,Sun, Lina,Zhang, Libin,Ru, Xiaoshang,Liu, Shilin,&Yang, Hongsheng.(2019).Metabolome responses of the sea cucumber Apostichopus japonicus to multiple environmental stresses: Heat and hypoxia.MARINE POLLUTION BULLETIN,138,407-420.
MLA Huo, Da,et al."Metabolome responses of the sea cucumber Apostichopus japonicus to multiple environmental stresses: Heat and hypoxia".MARINE POLLUTION BULLETIN 138(2019):407-420.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Huo, Da]'s Articles
[Sun, Lina]'s Articles
[Zhang, Libin]'s Articles
Baidu academic
Similar articles in Baidu academic
[Huo, Da]'s Articles
[Sun, Lina]'s Articles
[Zhang, Libin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Huo, Da]'s Articles
[Sun, Lina]'s Articles
[Zhang, Libin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.