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Macropinocytosis-dependent endocytosis of Japanese flounder IgM(+) B cells and its regulation by CD22
Li, Yi-qun1,2,3,4; Sun, Li1,2,3; Li, Jun2,3,5
2019
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume84Pages:138-147
Corresponding AuthorSun, Li(lsun@qdio.ac.cn) ; Li, Jun(jli@lssu.edu)
AbstractB cells in fish are proven to be endocytic and have a great contribution to innate immunity like phagocytosis. In this study, the endocytic capacity and the corresponding internalization pathways of IgM(+) B cells in Japanese flounder (Paralichthys olivaceus) were investigated. The results showed that IgM(+) B cells in peripheral blood leukocytes (PBL) and splenic leukocytes (SL) exhibited different abilities to ingest 0.5 mu m and 1 pm latex beads through macropinocytosis-dependent endocytic pathway. Japanese flounder CD22 (PoCD22) co-stimulatory signals were identified to be essential for the innate immune responses in B cells. Most of IgM+ B cells and some IgM(-) cells were demonstrated to be PoCD22 positive. When PoCD22 was blocked by antibody, the endocytic activities and reactive oxygen species (ROS) activities of SL IgM(+) B cells were significantly increased, while the endocytic and ROS activities of PBL IgM(+) B cells were significant decreased. These results collectively suggest that Japanese flounder IgM(+) B cells are able to employ macropinocytosis-dependent endocytic pathway, which is under the regulation of CD22.
KeywordParalichthys olivaceus IgM(+) B cells Endocytosis Macropinocytosis CD22 B cell regulation
DOI10.1016/j.fsi.2018.09.068
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31528019] ; AoShan Talents Program from Qingdao National Laboratory for Marine Science and Technology[2015ASTP] ; Taishan Scholar Program of Shandong Province
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000457666800017
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/160826
Collection实验海洋生物学重点实验室
Corresponding AuthorSun, Li; Li, Jun
Affiliation1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266071, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Lake Super State Univ, Sch Biol Sci, 650 W Easterday Ave, Sault Ste Marie, MI 49783 USA
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Yi-qun,Sun, Li,Li, Jun. Macropinocytosis-dependent endocytosis of Japanese flounder IgM(+) B cells and its regulation by CD22[J]. FISH & SHELLFISH IMMUNOLOGY,2019,84:138-147.
APA Li, Yi-qun,Sun, Li,&Li, Jun.(2019).Macropinocytosis-dependent endocytosis of Japanese flounder IgM(+) B cells and its regulation by CD22.FISH & SHELLFISH IMMUNOLOGY,84,138-147.
MLA Li, Yi-qun,et al."Macropinocytosis-dependent endocytosis of Japanese flounder IgM(+) B cells and its regulation by CD22".FISH & SHELLFISH IMMUNOLOGY 84(2019):138-147.
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