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Trained Innate Immunity of Fish Is a Viable Approach in Larval Aquaculture
Zhang, Zuobing1; Chi, Heng2,3; Dalmo, Roy A.3
2019-01-25
发表期刊FRONTIERS IN IMMUNOLOGY
ISSN1664-3224
卷号10页码:5
通讯作者Zhang, Zuobing(zbzhang@sxu.edu.cn) ; Chi, Heng(chiheng@qdio.ac.cn) ; Dalmo, Roy A.(roy.dalmo@uit.no)
摘要The general understanding has been that only adaptive immunity is capable of immunological memory, but this concept has been challenged in recent years by studies showing that innate immune systems can mount resistance to reinfection-as the innate immune system can adapt its function following an insult. Innate immune training offers an attractive approach in intensive fish larval rearing, especially since the adaptive immune system is not fully developed. Trained innate immunity will potentially favor robust fish in terms of resistance to viral and bacterial diseases. So-called immunostimulants such as beta-glucans have for decades been used both in laboratories and in intensive fish aquaculture. Treatment of fish by beta-glucans (and by other substances with pathogen-associated molecular patterns) often induces activation of non-specific/innate immune mechanisms and induces higher disease resistance. The reported effects of e.g., beta-glucans fit nicely into the concept "trained innate immunity," but the research on fish does not yet include analysis of epigenetic changes that may be a prerequisite for long-lasting trained innate immunity. In this "perspective," we will discuss how in practical terms and based on prior knowledge one can introduce innate immune training in brood stock fish, and their offspring, and whether innate immune training by beta-glucans is a viable approach in larval aquaculture.
关键词trained innate immunity aquaculture fish beta-glucan fish larvae
DOI10.3389/fimmu.2019.00042
收录类别SCI
语种英语
资助项目Research Council of Norway[237315] ; Research Council of Norway[239140] ; University of Tromso (UIT The Arctic University of Norway Open Access publication Fund) ; Tromso Research Foundation ; Research Council of Norway[237315] ; Research Council of Norway[239140] ; University of Tromso (UIT The Arctic University of Norway Open Access publication Fund) ; Tromso Research Foundation
WOS研究方向Immunology
WOS类目Immunology
WOS记录号WOS:000456847600001
出版者FRONTIERS MEDIA SA
引用统计
被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/160639
专题实验海洋生物学重点实验室
通讯作者Zhang, Zuobing; Chi, Heng; Dalmo, Roy A.
作者单位1.Shanxi Univ, Sch Life Sci, Taiyuan, Shanxi, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
3.Univ Tromso Arctic Univ Norway, Res Grp Aquaculture & Environm, Norwegian Coll Fishery Sci, Fac Biosci Fisheries & Econ, Tromso, Norway
通讯作者单位中国科学院海洋研究所
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Zhang, Zuobing,Chi, Heng,Dalmo, Roy A.. Trained Innate Immunity of Fish Is a Viable Approach in Larval Aquaculture[J]. FRONTIERS IN IMMUNOLOGY,2019,10:5.
APA Zhang, Zuobing,Chi, Heng,&Dalmo, Roy A..(2019).Trained Innate Immunity of Fish Is a Viable Approach in Larval Aquaculture.FRONTIERS IN IMMUNOLOGY,10,5.
MLA Zhang, Zuobing,et al."Trained Innate Immunity of Fish Is a Viable Approach in Larval Aquaculture".FRONTIERS IN IMMUNOLOGY 10(2019):5.
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