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Trained Innate Immunity of Fish Is a Viable Approach in Larval Aquaculture
Zhang, Zuobing1; Chi, Heng2,3; Dalmo, Roy A.3
Corresponding AuthorZhang, Zuobing( ; Chi, Heng( ; Dalmo, Roy A.(
AbstractThe general understanding has been that only adaptive immunity is capable of immunological memory, but this concept has been challenged in recent years by studies showing that innate immune systems can mount resistance to reinfection-as the innate immune system can adapt its function following an insult. Innate immune training offers an attractive approach in intensive fish larval rearing, especially since the adaptive immune system is not fully developed. Trained innate immunity will potentially favor robust fish in terms of resistance to viral and bacterial diseases. So-called immunostimulants such as beta-glucans have for decades been used both in laboratories and in intensive fish aquaculture. Treatment of fish by beta-glucans (and by other substances with pathogen-associated molecular patterns) often induces activation of non-specific/innate immune mechanisms and induces higher disease resistance. The reported effects of e.g., beta-glucans fit nicely into the concept "trained innate immunity," but the research on fish does not yet include analysis of epigenetic changes that may be a prerequisite for long-lasting trained innate immunity. In this "perspective," we will discuss how in practical terms and based on prior knowledge one can introduce innate immune training in brood stock fish, and their offspring, and whether innate immune training by beta-glucans is a viable approach in larval aquaculture.
Keywordtrained innate immunity aquaculture fish beta-glucan fish larvae
Indexed BySCI
Funding ProjectResearch Council of Norway[237315] ; Research Council of Norway[239140] ; University of Tromso (UIT The Arctic University of Norway Open Access publication Fund) ; Tromso Research Foundation
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000456847600001
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorZhang, Zuobing; Chi, Heng; Dalmo, Roy A.
Affiliation1.Shanxi Univ, Sch Life Sci, Taiyuan, Shanxi, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
3.Univ Tromso Arctic Univ Norway, Res Grp Aquaculture & Environm, Norwegian Coll Fishery Sci, Fac Biosci Fisheries & Econ, Tromso, Norway
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Zuobing,Chi, Heng,Dalmo, Roy A.. Trained Innate Immunity of Fish Is a Viable Approach in Larval Aquaculture[J]. FRONTIERS IN IMMUNOLOGY,2019,10:5.
APA Zhang, Zuobing,Chi, Heng,&Dalmo, Roy A..(2019).Trained Innate Immunity of Fish Is a Viable Approach in Larval Aquaculture.FRONTIERS IN IMMUNOLOGY,10,5.
MLA Zhang, Zuobing,et al."Trained Innate Immunity of Fish Is a Viable Approach in Larval Aquaculture".FRONTIERS IN IMMUNOLOGY 10(2019):5.
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