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Molecular characterization of a defender against apoptotic cell death 1 gene (CfDAD1) from the mollusk Chlamys farreri
Wang, M. Q.1,3; Wang, B. J.1; Liu, M.1; Jiang, K. Y.1; Wang, L.1,2,4
2018
发表期刊ISJ-INVERTEBRATE SURVIVAL JOURNAL
ISSN1824-307X
卷号15页码:294-301
通讯作者Wang, L.(wanglei@qdio.ac.cn)
摘要The defender against apoptotic cell death 1 (DAD1) was a negative regulator to inhibit the apoptosis process. In the present study, a DAD1 gene (designated as CfDAD1) was identified in Zhikong scallop Chlamys farreri. Its full-length cDNA sequence of CfDAD1 contained a 342 bp open reading frame (ORF), which encoded a mature protein of 113 amino acids. A DAD domain was revealed from the deduced protein sequence of CfDAD1. The mRNA transcripts of CfDAD1 could be detectable in all the investigated tissues, including hemocytes, muscle, mantle, gill, hepatopancreas and gonad, among which the maximum expression level were found in hemocytes. Being infected with Vibrio splendidus, Staphylococcus aureus or Yarrowia lipolytica, the mRNA expression levels of CfDAD1 in hemocytes were all significantly up-regulated. Moreover, the apoptosis level of CfDAD1-suppressed group was significant higher than those of control groups. All these results indicated that CfDAD1 was efficient negative regulator of apoptosis and involved in the innate immune responses of scallop.
关键词Apoptosis Chlamys farreri Innate immunity
收录类别SCI
语种英语
资助项目National Natural Science Foundation of China[U1706209] ; Qingdao National Laboratory for Marine Science and Technology[2016ASKJ07] ; Science and Technology Service Network Plan (STS) Major Deployment Project[KFZD-SW-106] ; STS Regional Centre Project (Fujian province) from Chinese Academy of Sciences ; National Natural Science Foundation of China[U1706209] ; Qingdao National Laboratory for Marine Science and Technology[2016ASKJ07] ; Science and Technology Service Network Plan (STS) Major Deployment Project[KFZD-SW-106] ; STS Regional Centre Project (Fujian province) from Chinese Academy of Sciences
WOS研究方向Immunology ; Zoology
WOS类目Immunology ; Zoology
WOS记录号WOS:000443548300005
出版者INVERTEBRATE SURVIVAL JOURNAL
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/160028
专题实验海洋生物学重点实验室
通讯作者Wang, L.
作者单位1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Res Platform Marine Mol Biotechnol, Qingdao 266237, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266400, Peoples R China
第一作者单位中国科学院海洋研究所
通讯作者单位中国科学院海洋研究所;  中国科学院海洋大科学研究中心
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Wang, M. Q.,Wang, B. J.,Liu, M.,et al. Molecular characterization of a defender against apoptotic cell death 1 gene (CfDAD1) from the mollusk Chlamys farreri[J]. ISJ-INVERTEBRATE SURVIVAL JOURNAL,2018,15:294-301.
APA Wang, M. Q.,Wang, B. J.,Liu, M.,Jiang, K. Y.,&Wang, L..(2018).Molecular characterization of a defender against apoptotic cell death 1 gene (CfDAD1) from the mollusk Chlamys farreri.ISJ-INVERTEBRATE SURVIVAL JOURNAL,15,294-301.
MLA Wang, M. Q.,et al."Molecular characterization of a defender against apoptotic cell death 1 gene (CfDAD1) from the mollusk Chlamys farreri".ISJ-INVERTEBRATE SURVIVAL JOURNAL 15(2018):294-301.
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