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An i-type lysozyme (CfLyzl) involved in innate immunity is essential for the survival of Chlamys farreri during Vibrio stimulation
Wang, M. Q.1,3; Wang, B. J.1; Liu, M.1; Jiang, K. Y.1; Wang, L.1,2,4
2018
Source PublicationISJ-INVERTEBRATE SURVIVAL JOURNAL
ISSN1824-307X
Volume15Pages:285-293
Corresponding AuthorWang, L.(wanglei@qdio.ac.cn)
AbstractLysozymes act as key components of the innate immunity in invertebrates and play a pivotal role in early defense against invading microbe infection. In this study, an i-type lysozyme homology was identified and characterized in Zhikong scallop Chlamys farreri (designated as CfLyzl). The full-length cDNA sequence of CfLyzl contained a 702 bp open reading frame (ORF), which encoded a polypeptide of 233 amino acids and contained a typical destabilase function domain. The mRNA transcripts of CfLyzl were detectable in all the investigated tissues, including hemocytes, muscle, mantle, gill, hepatopancreas and gonad with the peak level in hemocytes. Being stimulated by Vibrio splendidus, the mRNA transcripts of CfLyzl significantly increased in hemocytes. The CfLyzl-suppressed scallops turned to be more susceptible to Vibrio. All these results indicated that CfLyzl acted as an efficient effector in the innate immunity and was also essential for hosts' survival during Vibrio stimulation in Zhikong scallop.
KeywordChlamys farreri Innate immunity Invertebrate type lysozyme
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[U1706209] ; Polit National Laboratory for Marine Science and Technology[2016ASKJ07] ; Science and Technology Service Network Plan (STS) Major Deployment Project[KFZD-SW-106] ; STS Regional Centre Project (Fujian province) from Chinese Academy of Sciences
WOS Research AreaImmunology ; Zoology
WOS SubjectImmunology ; Zoology
WOS IDWOS:000443548300004
PublisherINVERTEBRATE SURVIVAL JOURNAL
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/159998
Collection实验海洋生物学重点实验室
Corresponding AuthorWang, L.
Affiliation1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol, Res Platform Marine Mol Biotechnol, Qingdao 266237, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266400, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wang, M. Q.,Wang, B. J.,Liu, M.,et al. An i-type lysozyme (CfLyzl) involved in innate immunity is essential for the survival of Chlamys farreri during Vibrio stimulation[J]. ISJ-INVERTEBRATE SURVIVAL JOURNAL,2018,15:285-293.
APA Wang, M. Q.,Wang, B. J.,Liu, M.,Jiang, K. Y.,&Wang, L..(2018).An i-type lysozyme (CfLyzl) involved in innate immunity is essential for the survival of Chlamys farreri during Vibrio stimulation.ISJ-INVERTEBRATE SURVIVAL JOURNAL,15,285-293.
MLA Wang, M. Q.,et al."An i-type lysozyme (CfLyzl) involved in innate immunity is essential for the survival of Chlamys farreri during Vibrio stimulation".ISJ-INVERTEBRATE SURVIVAL JOURNAL 15(2018):285-293.
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