Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| An i-type lysozyme (CfLyzl) involved in innate immunity is essential for the survival of Chlamys farreri during Vibrio stimulation | |
Wang, M. Q.1,3; Wang, B. J.1; Liu, M.1; Jiang, K. Y.1; Wang, L.1,2,4
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| 2018 | |
| Source Publication | ISJ-INVERTEBRATE SURVIVAL JOURNAL
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| ISSN | 1824-307X |
| Volume | 15Pages:285-293 |
| Corresponding Author | Wang, L.(wanglei@qdio.ac.cn) |
| Abstract | Lysozymes act as key components of the innate immunity in invertebrates and play a pivotal role in early defense against invading microbe infection. In this study, an i-type lysozyme homology was identified and characterized in Zhikong scallop Chlamys farreri (designated as CfLyzl). The full-length cDNA sequence of CfLyzl contained a 702 bp open reading frame (ORF), which encoded a polypeptide of 233 amino acids and contained a typical destabilase function domain. The mRNA transcripts of CfLyzl were detectable in all the investigated tissues, including hemocytes, muscle, mantle, gill, hepatopancreas and gonad with the peak level in hemocytes. Being stimulated by Vibrio splendidus, the mRNA transcripts of CfLyzl significantly increased in hemocytes. The CfLyzl-suppressed scallops turned to be more susceptible to Vibrio. All these results indicated that CfLyzl acted as an efficient effector in the innate immunity and was also essential for hosts' survival during Vibrio stimulation in Zhikong scallop. |
| Keyword | Chlamys farreri Innate immunity Invertebrate type lysozyme |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[U1706209] ; Polit National Laboratory for Marine Science and Technology[2016ASKJ07] ; Science and Technology Service Network Plan (STS) Major Deployment Project[KFZD-SW-106] ; STS Regional Centre Project (Fujian province) from Chinese Academy of Sciences ; National Natural Science Foundation of China[U1706209] ; Polit National Laboratory for Marine Science and Technology[2016ASKJ07] ; Science and Technology Service Network Plan (STS) Major Deployment Project[KFZD-SW-106] ; STS Regional Centre Project (Fujian province) from Chinese Academy of Sciences |
| WOS Research Area | Immunology ; Zoology |
| WOS Subject | Immunology ; Zoology |
| WOS ID | WOS:000443548300004 |
| Publisher | INVERTEBRATE SURVIVAL JOURNAL |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/159998 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Wang, L. |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol, Res Platform Marine Mol Biotechnol, Qingdao 266237, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266400, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Wang, M. Q.,Wang, B. J.,Liu, M.,et al. An i-type lysozyme (CfLyzl) involved in innate immunity is essential for the survival of Chlamys farreri during Vibrio stimulation[J]. ISJ-INVERTEBRATE SURVIVAL JOURNAL,2018,15:285-293. |
| APA | Wang, M. Q.,Wang, B. J.,Liu, M.,Jiang, K. Y.,&Wang, L..(2018).An i-type lysozyme (CfLyzl) involved in innate immunity is essential for the survival of Chlamys farreri during Vibrio stimulation.ISJ-INVERTEBRATE SURVIVAL JOURNAL,15,285-293. |
| MLA | Wang, M. Q.,et al."An i-type lysozyme (CfLyzl) involved in innate immunity is essential for the survival of Chlamys farreri during Vibrio stimulation".ISJ-INVERTEBRATE SURVIVAL JOURNAL 15(2018):285-293. |
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| An i-type lysozyme (（1170KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View | |
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