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The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity
Liu, Huaide1; Wang, Jing2,3,4; Zhang, Quanbin2,3; Zhang, Hong2,3
2018-07-01
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
Volume113Pages:82-89
Corresponding AuthorWang, Jing(jingwang@qdio.ac.cn)
AbstractTen fucoidan (FPS) derivatives were successfully synthesized, and their potential neuroprotective and anticomplement activities were investigated employing various established in vitro systems. The aim of the present study was to investigate the effects of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activities. All FPS derivatives possessed considerable neuroprotective and anticomplement activities and had stronger activities than FPS in certain tests. The in vitro results found that sulfated and benzoylated derivatives could reverse the decreased mitochondrial activity and decreased lactate dehydrogenase (LDH) and reactive oxygen species (ROS) release induced by 6-hydroxydopamine (6-OHDA, P < 0.01 or P < 0.001), which provides further evidence that sulfate and benzoylate groups could enhance the neuroprotective activity of fucoidan. In anticomplement experiments, all samples showed anticomplement activity in both systems; however, the sulfated and benzoylated derivatives showed better activity than fucoidan, with higher molecular weights showing the strongest activity. Available data suggested that substituted groups of fucoidan played an important role on neuroprotective and anticomplement activities. The mechanism of the influence of the neuroprotective and anticomplement activities of samples of the substituted groups was indicated. (C) 2018 Published by Elsevier B.V.
KeywordFucoidan derivatives Molecular weights Substitute group Neuroprotective Anticomplement
DOI10.1016/j.ijbiomac.2018.02.109
Indexed BySCI
Language英语
Funding ProjectFujian the Science and Technology Project of Fujian Province[2017T3015] ; Science and Technology Project of Shandong Province[2016GSF115031] ; Open Fund Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology[0F2015N007] ; Youth Innovation Promotion Association of CAS[2016190] ; Natural Science Foundation of China (NSFC)[41406144] ; Natural Science Foundation of the Jiangsu Higher Education Institutions of China[15KJB170016]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS IDWOS:000432503100011
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/159246
Collection实验海洋生物学重点实验室
Corresponding AuthorWang, Jing
Affiliation1.Nantong Univ, Sch Ocean, Sch Life Sci, Nantong, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Nantong Branch, Nantong, Jiangsu, Peoples R China
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Liu, Huaide,Wang, Jing,Zhang, Quanbin,et al. The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,113:82-89.
APA Liu, Huaide,Wang, Jing,Zhang, Quanbin,&Zhang, Hong.(2018).The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,113,82-89.
MLA Liu, Huaide,et al."The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 113(2018):82-89.
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