Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Beclin-1 is involved in tongue sole Cynoglossus semilaevis immune defense against bacterial infection | |
Li, Xue-peng1,2 ; Chi, Heng1,2; Zhang, Jian1,2
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| 2018-06-01 | |
| Source Publication | FISH & SHELLFISH IMMUNOLOGY
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| ISSN | 1050-4648 |
| Volume | 77Pages:8-12 |
| Corresponding Author | Zhang, Jian(zhangjian@qdio.ac.cn) |
| Abstract | In mammals, beclin-1 is a key player that regulates autophagic activity. In fish, the immune function of beclin-1 is essentially unknown. In this study, we analyzed the involvement of tongue sole (Cynoglossus semilaevis) beclin-1 (named CsBECN1) in antibacterial immunity. CsBECN1 is composed of 451 amino acid residues and shares 84.5-95.1% overall sequence identities with other teleost beclin-1. CsBECN1 possesses a typical Bcl-2 homology domain 3 and an Atg6 domain. Expression of CsBECN1 occurred in multiple tissues and was upregulated during bacterial infection. Knockdown of CsBECN1 significantly enhanced bacterial dissemination in the tissues of tongue sole, whereas overexpression of CsBECN1 significantly reduced bacterial dissemination. Taken together, these results indicate that CsBECN1 is required for the antibacterial immunity of tongue sole. |
| Keyword | Beclin-1 Cynoglossus semilaevis Gene expression Immune defense |
| DOI | 10.1016/j.fsi.2018.03.023 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[31330081] ; National Natural Science Foundation of China[31502197] ; Key Laboratory of Mariculture (KLM), Ministry of Education, Ocean University of China ; Taishan Scholar Program of Shandong Province |
| WOS Research Area | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| WOS Subject | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| WOS ID | WOS:000432644300002 |
| Publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/159212 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Zhang, Jian |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Li, Xue-peng,Chi, Heng,Zhang, Jian. Beclin-1 is involved in tongue sole Cynoglossus semilaevis immune defense against bacterial infection[J]. FISH & SHELLFISH IMMUNOLOGY,2018,77:8-12. |
| APA | Li, Xue-peng,Chi, Heng,&Zhang, Jian.(2018).Beclin-1 is involved in tongue sole Cynoglossus semilaevis immune defense against bacterial infection.FISH & SHELLFISH IMMUNOLOGY,77,8-12. |
| MLA | Li, Xue-peng,et al."Beclin-1 is involved in tongue sole Cynoglossus semilaevis immune defense against bacterial infection".FISH & SHELLFISH IMMUNOLOGY 77(2018):8-12. |
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