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Beclin-1 is involved in tongue sole Cynoglossus semilaevis immune defense against bacterial infection
Li, Xue-peng1,2; Chi, Heng1,2; Zhang, Jian1,2
2018-06-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume77Pages:8-12
Corresponding AuthorZhang, Jian(zhangjian@qdio.ac.cn)
AbstractIn mammals, beclin-1 is a key player that regulates autophagic activity. In fish, the immune function of beclin-1 is essentially unknown. In this study, we analyzed the involvement of tongue sole (Cynoglossus semilaevis) beclin-1 (named CsBECN1) in antibacterial immunity. CsBECN1 is composed of 451 amino acid residues and shares 84.5-95.1% overall sequence identities with other teleost beclin-1. CsBECN1 possesses a typical Bcl-2 homology domain 3 and an Atg6 domain. Expression of CsBECN1 occurred in multiple tissues and was upregulated during bacterial infection. Knockdown of CsBECN1 significantly enhanced bacterial dissemination in the tissues of tongue sole, whereas overexpression of CsBECN1 significantly reduced bacterial dissemination. Taken together, these results indicate that CsBECN1 is required for the antibacterial immunity of tongue sole.
KeywordBeclin-1 Cynoglossus semilaevis Gene expression Immune defense
DOI10.1016/j.fsi.2018.03.023
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31330081] ; National Natural Science Foundation of China[31502197] ; Key Laboratory of Mariculture (KLM), Ministry of Education, Ocean University of China ; Taishan Scholar Program of Shandong Province
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000432644300002
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
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Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/159212
Collection实验海洋生物学重点实验室
Corresponding AuthorZhang, Jian
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Xue-peng,Chi, Heng,Zhang, Jian. Beclin-1 is involved in tongue sole Cynoglossus semilaevis immune defense against bacterial infection[J]. FISH & SHELLFISH IMMUNOLOGY,2018,77:8-12.
APA Li, Xue-peng,Chi, Heng,&Zhang, Jian.(2018).Beclin-1 is involved in tongue sole Cynoglossus semilaevis immune defense against bacterial infection.FISH & SHELLFISH IMMUNOLOGY,77,8-12.
MLA Li, Xue-peng,et al."Beclin-1 is involved in tongue sole Cynoglossus semilaevis immune defense against bacterial infection".FISH & SHELLFISH IMMUNOLOGY 77(2018):8-12.
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