Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization

doi:10.3390/molecules23030594

IOCAS-IR > 实验海洋生物学重点实验室

	Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization
	Qin, Yukun 1,2; Liu, Weixiang 1,2,3; Xing, Ronge1,2 ; Liu, Song 1,2; Li, Kecheng 1,2; Li, Pengcheng1,2
	2018-03-01
发表期刊	MOLECULES
ISSN	1420-3049
卷号	23 期号:3 页码:13
摘要	In this study, 3-methyl-1,2,4-triazolyl chitosan (MTACS) and 3-chloromethyl-1,2,4-triazolyl chitosan (CMTACS) were prepared via cyclization of acyl thiourea chitosan (TUGS). Their structures were confirmed by FT-IR, H-1-NMR, elemental analysis, DSC, XRD, and SEM. The conformations were predicted using the Gaussian 09 program. Additionally, the antifungal properties of MTACS and CMTACS against Stemphylium solani weber (S. solani), Alternaria porn (A. porfi), and Gloeosporium theae-sinensis (G. theae-sinensis) were assayed in vitro and ranged from 250 mu g/mL to 1000 mu g/mL. The results showed that MTACS and CMTACS exhibited enhanced inhibitory effect on the selected fungi compared to the original chitosan and TUCS. In particular, they displayed better antifungal activities against A. porn and G. theae-sinensis than that of the positive control, Triadimefon. The findings described here may lead to them being used as antifungal agents for crop protection.
关键词	synthesis 1,2,4-triazolyl acyl thiourea chitosan antifungal activity
DOI	10.3390/molecules23030594
收录类别	SCI
语种	英语
资助项目	NSFC Shandong joint fund[U1606403] ; Qingdao science and technology plan[17-3-3-60-nsh] ; National Natural Science Foundation of China[41306071] ; Key Research Program of the Chinese Academy of Sciences[KFZD-SW-106] ; Key Research Program of the Chinese Academy of Sciences[KFZD-SW-106] ; National Natural Science Foundation of China[41306071] ; Qingdao science and technology plan[17-3-3-60-nsh] ; NSFC Shandong joint fund[U1606403]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000428514100085
出版者	MDPI
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/158970
专题	实验海洋生物学重点实验室
通讯作者	Qin, Yukun; Li, Pengcheng
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Qin, Yukun,Liu, Weixiang,Xing, Ronge,et al. Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization[J]. MOLECULES,2018,23(3):13.
APA	Qin, Yukun,Liu, Weixiang,Xing, Ronge,Liu, Song,Li, Kecheng,&Li, Pengcheng.(2018).Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization.MOLECULES,23(3),13.
MLA	Qin, Yukun,et al."Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization".MOLECULES 23.3(2018):13.

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Cyclization Reaction（5247KB）	期刊论文	作者接受稿	限制开放	CC BY-NC-SA	浏览