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Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization
Qin, Yukun1,2; Liu, Weixiang1,2,3; Xing, Ronge1,2; Liu, Song1,2; Li, Kecheng1,2; Li, Pengcheng1,2
2018-03-01
Source PublicationMOLECULES
ISSN1420-3049
Volume23Issue:3Pages:13
Corresponding AuthorQin, Yukun(ykqin@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
AbstractIn this study, 3-methyl-1,2,4-triazolyl chitosan (MTACS) and 3-chloromethyl-1,2,4-triazolyl chitosan (CMTACS) were prepared via cyclization of acyl thiourea chitosan (TUGS). Their structures were confirmed by FT-IR, H-1-NMR, elemental analysis, DSC, XRD, and SEM. The conformations were predicted using the Gaussian 09 program. Additionally, the antifungal properties of MTACS and CMTACS against Stemphylium solani weber (S. solani), Alternaria porn (A. porfi), and Gloeosporium theae-sinensis (G. theae-sinensis) were assayed in vitro and ranged from 250 mu g/mL to 1000 mu g/mL. The results showed that MTACS and CMTACS exhibited enhanced inhibitory effect on the selected fungi compared to the original chitosan and TUCS. In particular, they displayed better antifungal activities against A. porn and G. theae-sinensis than that of the positive control, Triadimefon. The findings described here may lead to them being used as antifungal agents for crop protection.
Keywordsynthesis 1,2,4-triazolyl acyl thiourea chitosan antifungal activity
DOI10.3390/molecules23030594
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[41306071] ; Qingdao science and technology plan[17-3-3-60-nsh] ; NSFC Shandong joint fund[U1606403] ; key Research Program of the Chinese Academy of Sciences[KFZD-SW-106]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000428514100085
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/158970
Collection实验海洋生物学重点实验室
Corresponding AuthorQin, Yukun; Li, Pengcheng
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Qin, Yukun,Liu, Weixiang,Xing, Ronge,et al. Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization[J]. MOLECULES,2018,23(3):13.
APA Qin, Yukun,Liu, Weixiang,Xing, Ronge,Liu, Song,Li, Kecheng,&Li, Pengcheng.(2018).Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization.MOLECULES,23(3),13.
MLA Qin, Yukun,et al."Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization".MOLECULES 23.3(2018):13.
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