Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| A Ultrasensitive Near-Infrared Fluorescent Probe Reveals Pyroglutamate Aminopeptidase 1 Can Be a New Inflammatory Cytokine | |
| Gong, Qiuyu1,2,3; Zou, Ruifen1,2,3,4; Xing, Jie1,2,3,4; Xiang, Lingchao1,2,3; Zhang, Renshuai5; Wu, Aiguo1,2,3 | |
| 2018-04-01 | |
| 发表期刊 | ADVANCED SCIENCE
 |
| ISSN | 2198-3844 |
| 卷号 | 5期号:4页码:7 |
| 通讯作者 | Wu, Aiguo(aiguo@nimte.ac.cn) |
| 摘要 | Previous study showed that pyroglutamate aminopeptidase 1 (PGP-1) has a relationship with the immune response in cells. However, whether PGP-1 is involved in inflammatory response in vivo and can serve as a new inflammatory cytokine are still unclear. To address these issues, a new near-infrared fluorescent probe, which exhibits high selectivity and super sensitivity, is developed. With this probe, the up-regulation of PGP-1 (evidenced by western blot) in BALB/c mice legs and livers under the stimulation of two main immunopotentiators is revealed for the first time. The occurrence of inflammatory process (including tissue necrosis) in mice is determined by up-regulation of tumor necrosis factor-alpha and hematoxylin-eosin staining. Interestingly, it is revealed for the first time that knocking down PGP-1 leads to the weakness of inflammatory process in RAW264.7 cells. These new findings suggest that PGP-1 is indeed involved in inflammatory response in vivo and can be a new inflammatory cytokine. |
| 关键词 | inflammatory cytokine near-infrared fluorescent probes pyroglutamate aminopeptidase 1 |
| DOI | 10.1002/advs.201700664 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | China Postdoctoral Science Foundation[2016M601983] ; National Nature Science Foundation of China[21705157] ; National Nature Science Foundation of China[U1432114] ; Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund[U1501501] ; Hundred Talents Program of Chinese Academy of Sciences[2010-735] ; Key Breakthrough Program of Chinese Academy of Sciences[KGZD-EW-T06] ; Science & Technology Bureau of Ningbo City[2015C50004] ; Science & Technology Bureau of Ningbo City[2015B11002] ; Science & Technology Bureau of Ningbo City[2017C110022] ; Zhejiang Province Financial Supporting[2017C03042] ; Zhejiang Province Financial Supporting[LY18H180011] ; China Postdoctoral Science Foundation[2016M601983] ; National Nature Science Foundation of China[21705157] ; National Nature Science Foundation of China[U1432114] ; Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund[U1501501] ; Hundred Talents Program of Chinese Academy of Sciences[2010-735] ; Key Breakthrough Program of Chinese Academy of Sciences[KGZD-EW-T06] ; Science & Technology Bureau of Ningbo City[2015C50004] ; Science & Technology Bureau of Ningbo City[2015B11002] ; Science & Technology Bureau of Ningbo City[2017C110022] ; Zhejiang Province Financial Supporting[2017C03042] ; Zhejiang Province Financial Supporting[LY18H180011] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| WOS记录号 | WOS:000430460200012 |
| 出版者 | WILEY |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/158709 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Wu, Aiguo |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Magnet Mat & Devices CAS, 1219 ZhongGuan West Rd, Ningbo 315201, Zhejiang, Peoples R China 2.Chinese Acad Sci, Key Lab Addit Mfg Mat Zhejiang Prov, 1219 ZhongGuan West Rd, Ningbo 315201, Zhejiang, Peoples R China 3.Chinese Acad Sci, Div Funct Mat & Nanodevices, Ningbo Inst Mat Technol & Engn, 1219 ZhongGuan West Rd, Ningbo 315201, Zhejiang, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gong, Qiuyu,Zou, Ruifen,Xing, Jie,et al. A Ultrasensitive Near-Infrared Fluorescent Probe Reveals Pyroglutamate Aminopeptidase 1 Can Be a New Inflammatory Cytokine[J]. ADVANCED SCIENCE,2018,5(4):7. |
| APA | Gong, Qiuyu,Zou, Ruifen,Xing, Jie,Xiang, Lingchao,Zhang, Renshuai,&Wu, Aiguo.(2018).A Ultrasensitive Near-Infrared Fluorescent Probe Reveals Pyroglutamate Aminopeptidase 1 Can Be a New Inflammatory Cytokine.ADVANCED SCIENCE,5(4),7. |
| MLA | Gong, Qiuyu,et al."A Ultrasensitive Near-Infrared Fluorescent Probe Reveals Pyroglutamate Aminopeptidase 1 Can Be a New Inflammatory Cytokine".ADVANCED SCIENCE 5.4(2018):7. |
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