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A Ultrasensitive Near-Infrared Fluorescent Probe Reveals Pyroglutamate Aminopeptidase 1 Can Be a New Inflammatory Cytokine
Gong, Qiuyu1,2,3; Zou, Ruifen1,2,3,4; Xing, Jie1,2,3,4; Xiang, Lingchao1,2,3; Zhang, Renshuai5; Wu, Aiguo1,2,3
2018-04-01
Source PublicationADVANCED SCIENCE
ISSN2198-3844
Volume5Issue:4Pages:7
Corresponding AuthorWu, Aiguo(aiguo@nimte.ac.cn)
AbstractPrevious study showed that pyroglutamate aminopeptidase 1 (PGP-1) has a relationship with the immune response in cells. However, whether PGP-1 is involved in inflammatory response in vivo and can serve as a new inflammatory cytokine are still unclear. To address these issues, a new near-infrared fluorescent probe, which exhibits high selectivity and super sensitivity, is developed. With this probe, the up-regulation of PGP-1 (evidenced by western blot) in BALB/c mice legs and livers under the stimulation of two main immunopotentiators is revealed for the first time. The occurrence of inflammatory process (including tissue necrosis) in mice is determined by up-regulation of tumor necrosis factor-alpha and hematoxylin-eosin staining. Interestingly, it is revealed for the first time that knocking down PGP-1 leads to the weakness of inflammatory process in RAW264.7 cells. These new findings suggest that PGP-1 is indeed involved in inflammatory response in vivo and can be a new inflammatory cytokine.
Keywordinflammatory cytokine near-infrared fluorescent probes pyroglutamate aminopeptidase 1
DOI10.1002/advs.201700664
Indexed BySCI
Language英语
Funding ProjectChina Postdoctoral Science Foundation[2016M601983] ; National Nature Science Foundation of China[21705157] ; National Nature Science Foundation of China[U1432114] ; Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund[U1501501] ; Hundred Talents Program of Chinese Academy of Sciences[2010-735] ; Key Breakthrough Program of Chinese Academy of Sciences[KGZD-EW-T06] ; Science & Technology Bureau of Ningbo City[2015C50004] ; Science & Technology Bureau of Ningbo City[2015B11002] ; Science & Technology Bureau of Ningbo City[2017C110022] ; Zhejiang Province Financial Supporting[2017C03042] ; Zhejiang Province Financial Supporting[LY18H180011]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000430460200012
PublisherWILEY
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/158709
Collection实验海洋生物学重点实验室
Corresponding AuthorWu, Aiguo
Affiliation1.Chinese Acad Sci, Key Lab Magnet Mat & Devices CAS, 1219 ZhongGuan West Rd, Ningbo 315201, Zhejiang, Peoples R China
2.Chinese Acad Sci, Key Lab Addit Mfg Mat Zhejiang Prov, 1219 ZhongGuan West Rd, Ningbo 315201, Zhejiang, Peoples R China
3.Chinese Acad Sci, Div Funct Mat & Nanodevices, Ningbo Inst Mat Technol & Engn, 1219 ZhongGuan West Rd, Ningbo 315201, Zhejiang, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Gong, Qiuyu,Zou, Ruifen,Xing, Jie,et al. A Ultrasensitive Near-Infrared Fluorescent Probe Reveals Pyroglutamate Aminopeptidase 1 Can Be a New Inflammatory Cytokine[J]. ADVANCED SCIENCE,2018,5(4):7.
APA Gong, Qiuyu,Zou, Ruifen,Xing, Jie,Xiang, Lingchao,Zhang, Renshuai,&Wu, Aiguo.(2018).A Ultrasensitive Near-Infrared Fluorescent Probe Reveals Pyroglutamate Aminopeptidase 1 Can Be a New Inflammatory Cytokine.ADVANCED SCIENCE,5(4),7.
MLA Gong, Qiuyu,et al."A Ultrasensitive Near-Infrared Fluorescent Probe Reveals Pyroglutamate Aminopeptidase 1 Can Be a New Inflammatory Cytokine".ADVANCED SCIENCE 5.4(2018):7.
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