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Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet
Cai, Zhenyuan1,2; Wang, Liuyang3; Song, Xiaoying4; Tagore, Somnath5; Li, Xiangfeng2; Wang, Huihua6; Chen, Jiarui1,2; Li, Kexin6,7; Frenkel, Zeev7; Gao, Dahai8; Frenkel-Morgenstern, Milana5; Zhang, Tongzuo1,9; Nevo, Eviatar7
2018-03-16
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume8Pages:11
Corresponding AuthorFrenkel-Morgenstern, Milana(milana.morgenstern@biu.ac.il) ; Zhang, Tongzuo(zhangtz@nwipb.cas.cn) ; Nevo, Eviatar(nevo@research.haifa.ac.il)
AbstractAnimals living at high altitudes have evolved distinct phenotypic and genotypic adaptations against stressful environments. We studied the adaptive patterns of altitudinal stresses on transcriptome turnover in subterranean plateau zokors (Myospalax baileyi) in the high-altitude Qinghai-Tibetan Plateau. Transcriptomes of zokors from three populations with distinct altitudes and ecologies (Low: 2846 m, Middle: 3282 m, High: 3,714 m) were sequenced and compared. Phylogenetic and principal component analyses classified them into three divergent altitudinal population clusters. Genetic polymorphisms showed that the population at H, approaching the uppermost species boundary, harbors the highest genetic polymorphism. Moreover, 1056 highly up-regulated UniGenes were identified from M to H. Gene ontologies reveal genes like EPAS1 and COX1 were overexpressed under hypoxia conditions. EPAS1, EGLN1, and COX1 were convergent in high-altitude adaptation against stresses in other species. The fixation indices (FST and GST)-based outlier analysis identified 191 and 211 genes, highly differentiated among L, M, and H. We observed adaptive transcriptome changes in Myospalax baileyi, across a few hundred meters, near the uppermost species boundary, regardless of their relatively stable underground burrows' microclimate. The highly variant genes identified in Myospalax were involved in hypoxia tolerance, hypercapnia tolerance, ATP-pathway energetics, and temperature changes.
DOI10.1038/s41598-018-22483-7
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31370405] ; Key Technology Research and Development Program of Qinghai Province[2014-NS-113] ; CAS Key Technology Talent Program ; Ancell-Teicher Research Foundation for Genetics and Molecular Evolution ; Agricultural Science and Technology Innovation Program[CAAS-ASTIP-2016-IAR] ; VATAT ; VATAT[22351] ; Israel Cancer Association[204562]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000427585900005
PublisherNATURE PUBLISHING GROUP
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/158419
Collection实验海洋生物学重点实验室
Corresponding AuthorFrenkel-Morgenstern, Milana; Zhang, Tongzuo; Nevo, Eviatar
Affiliation1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810008, Qinghai, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27708 USA
4.Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Henan, Peoples R China
5.Bar Ilan Univ, Azrieli Fac Med, IL-13195 Safed, Israel
6.Chinese Acad Sci, Inst Apicultural Res, Beijing 100093, Peoples R China
7.Univ Haifa, Inst Evolut, 199 Aba Khoushy Ave, IL-3498838 Haifa, Israel
8.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China
9.Qinghai Prov Key Lab Anim Ecol Genom, Xining 810008, Qinghai, Peoples R China
Recommended Citation
GB/T 7714
Cai, Zhenyuan,Wang, Liuyang,Song, Xiaoying,et al. Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet[J]. SCIENTIFIC REPORTS,2018,8:11.
APA Cai, Zhenyuan.,Wang, Liuyang.,Song, Xiaoying.,Tagore, Somnath.,Li, Xiangfeng.,...&Nevo, Eviatar.(2018).Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet.SCIENTIFIC REPORTS,8,11.
MLA Cai, Zhenyuan,et al."Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet".SCIENTIFIC REPORTS 8(2018):11.
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