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The Evaluation and Utilization of Marine-derived Bioactive Compounds with Anti-Obesity Effect
Jin, Qiu1,2,3; Yu, Huahua1,2; Li, Pengcheng1,2
2018
Source PublicationCURRENT MEDICINAL CHEMISTRY
ISSN0929-8673
Volume25Issue:7Pages:861-878
Corresponding AuthorYu, Huahua(yuhuahua@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
AbstractBackground: Obesity is a global epidemic throughout the world. There is thus increasing interest in searching for natural bioactive compounds with anti-obesity effect. A number of marine compounds have been regarded as potential sources of bioactive compounds and are associated with an anti-obesity effect. Objective: Marine-derived compounds with anti-obesity effect and their current applications, methods and indicators for the evaluation of anti-obesity activity are summarized in this review. in order to make contributions to the development of marine-derived functional food against obesity. Results: In this review, an overview of marine-derived compounds with anti-obesity effect, including marine polysaccharides, marine lipid, marine peptides, marine carotenoids is intensively made with an emphasis on their efficacy and mechanism of action. Meanwhile, methods and indicators for the evaluation of anti-obesity activity are discussed. We summarize these methods into three categories: in vitro assay (including adsorption experiments and enzyme inhibitory assay), cell line study, animal experiments and clinical experiments. In addition, a brief introduction of the current applications of marine bioactive compounds with anti-obesity activity is discussed. Conclusion: Marine environment is a rich source of both biological and chemical diversity. In the past decades, numerous novel compounds with anti-obesity activity have been obtained from marine organisms, and many of them have been applied to industrial production such as functional foods and pharmaceuticals. Further studies are needed to explore the above-mentioned facts.
KeywordAnti-obesity marine-derived digestive enzyme appetite fat absorption adipogenesis thermogenesis utilization
DOI10.2174/0929867324666170602082620
Indexed BySCI
Language英语
Funding ProjectNSFC-Shandong Joint Fund[U1606403] ; major projects of independent, Shandong[2013CXB80203]
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000427719500006
PublisherBENTHAM SCIENCE PUBL LTD
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Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/158391
Collection实验海洋生物学重点实验室
Corresponding AuthorYu, Huahua; Li, Pengcheng
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd,7 Qingdao,Nanhai Rd, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Jin, Qiu,Yu, Huahua,Li, Pengcheng. The Evaluation and Utilization of Marine-derived Bioactive Compounds with Anti-Obesity Effect[J]. CURRENT MEDICINAL CHEMISTRY,2018,25(7):861-878.
APA Jin, Qiu,Yu, Huahua,&Li, Pengcheng.(2018).The Evaluation and Utilization of Marine-derived Bioactive Compounds with Anti-Obesity Effect.CURRENT MEDICINAL CHEMISTRY,25(7),861-878.
MLA Jin, Qiu,et al."The Evaluation and Utilization of Marine-derived Bioactive Compounds with Anti-Obesity Effect".CURRENT MEDICINAL CHEMISTRY 25.7(2018):861-878.
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