The Evaluation and Utilization of Marine-derived Bioactive Compounds with Anti-Obesity Effect

doi:10.2174/0929867324666170602082620

IOCAS-IR > 实验海洋生物学重点实验室

	The Evaluation and Utilization of Marine-derived Bioactive Compounds with Anti-Obesity Effect
	Jin, Qiu1,2,3 ; Yu, Huahua1,2 ; Li, Pengcheng1,2
	2018
发表期刊	CURRENT MEDICINAL CHEMISTRY
ISSN	0929-8673
卷号	25 期号:7 页码:861-878
通讯作者	Yu, Huahua(yuhuahua@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
摘要	Background: Obesity is a global epidemic throughout the world. There is thus increasing interest in searching for natural bioactive compounds with anti-obesity effect. A number of marine compounds have been regarded as potential sources of bioactive compounds and are associated with an anti-obesity effect. Objective: Marine-derived compounds with anti-obesity effect and their current applications, methods and indicators for the evaluation of anti-obesity activity are summarized in this review. in order to make contributions to the development of marine-derived functional food against obesity. Results: In this review, an overview of marine-derived compounds with anti-obesity effect, including marine polysaccharides, marine lipid, marine peptides, marine carotenoids is intensively made with an emphasis on their efficacy and mechanism of action. Meanwhile, methods and indicators for the evaluation of anti-obesity activity are discussed. We summarize these methods into three categories: in vitro assay (including adsorption experiments and enzyme inhibitory assay), cell line study, animal experiments and clinical experiments. In addition, a brief introduction of the current applications of marine bioactive compounds with anti-obesity activity is discussed. Conclusion: Marine environment is a rich source of both biological and chemical diversity. In the past decades, numerous novel compounds with anti-obesity activity have been obtained from marine organisms, and many of them have been applied to industrial production such as functional foods and pharmaceuticals. Further studies are needed to explore the above-mentioned facts.
关键词	Anti-obesity marine-derived digestive enzyme appetite fat absorption adipogenesis thermogenesis utilization
DOI	10.2174/0929867324666170602082620
收录类别	SCI
语种	英语
资助项目	NSFC-Shandong joint Fund[U1606403] ; major projects of independent, Shandong[2013CXB80203] ; NSFC-Shandong Joint Fund[U1606403] ; major projects of independent, Shandong[2013CXB80203]
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:000427719500006
出版者	BENTHAM SCIENCE PUBL LTD
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/158391
专题	实验海洋生物学重点实验室
通讯作者	Yu, Huahua; Li, Pengcheng
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd,7 Qingdao,Nanhai Rd, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Jin, Qiu,Yu, Huahua,Li, Pengcheng. The Evaluation and Utilization of Marine-derived Bioactive Compounds with Anti-Obesity Effect[J]. CURRENT MEDICINAL CHEMISTRY,2018,25(7):861-878.
APA	Jin, Qiu,Yu, Huahua,&Li, Pengcheng.(2018).The Evaluation and Utilization of Marine-derived Bioactive Compounds with Anti-Obesity Effect.CURRENT MEDICINAL CHEMISTRY,25(7),861-878.
MLA	Jin, Qiu,et al."The Evaluation and Utilization of Marine-derived Bioactive Compounds with Anti-Obesity Effect".CURRENT MEDICINAL CHEMISTRY 25.7(2018):861-878.

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