IOCAS-IR
Internalization of large particles by turbot (Scophthalmus maximus) IgM(+) B cells mainly depends on macropinocytosis
Li, Yi-qun1,2,3; Sun, Li1,2; Li, Jun4,5
2018-05-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN0145-305X
Volume82Pages:31-38
Corresponding AuthorSun, Li(lsun@qdio.ac.cn) ; Li, Jun(jli@lssu.edu)
AbstractIncreasing evidence has demonstrated support for the endocytic capacities of teleost B cells. In the present study, the ability of turbot IgM(+) B cells to ingest microspheres of different sizes and the corresponding internalization pathways were investigated. The results showed that IgM(+) B cells exhibited relatively high endocytic capacities for 0.5 mu m and 1 mu m latex beads, and that different mechanisms were employed for IgM(+) and IgM(-) cells to uptake 0.5 gm and 1 gm beads. For 0.5 gm beads, IgM(+) B cells apparently employed macropinocytosis-dependent endocytic pathway, whereas IgM(-) cells utilized a different process involving both clathrin-and caveolae-mediated pathways. For the uptake of 1 mu m beads, IgM(+) cells relied mainly on macropinocytosis and partially on caveolae-mediated pathway, while IgM(-) cells utilized the routes similar to that of internalizing 0.5 mu m beads. Consistently, the internalized microspheres were co-localized with high-molecular-mass dextran in IgM(+) phagocytic cells. In addition to latex beads, IgM(+) B cells could also ingest inactivated bacteria predominately through macropinocytosis and caveolae-mediated endocytosis. These results collectively indicated that macropinocytosis is principally responsible for particle uptake by turbot IgM(+) B cells. (C) 2018 Elsevier Ltd. All rights reserved.
KeywordScophthalmus maximus IgM(+) cells Endocytosis Macropinocytosis
DOI10.1016/j.dci.2017.12.028
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31528019] ; AoShan Talents Program from Qingdao National Laboratory for Marine Science and Technology[2015ASTP] ; Taishan Scholar Program of Shandong Province
WOS Research AreaFisheries ; Immunology ; Zoology
WOS SubjectFisheries ; Immunology ; Zoology
WOS IDWOS:000427668700003
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/158342
Collection中国科学院海洋研究所
Corresponding AuthorSun, Li; Li, Jun
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266071, Peoples R China
5.Lake Super State Univ, Sch Biol Sci, Sault Ste Marie, MI 49783 USA
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Yi-qun,Sun, Li,Li, Jun. Internalization of large particles by turbot (Scophthalmus maximus) IgM(+) B cells mainly depends on macropinocytosis[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2018,82:31-38.
APA Li, Yi-qun,Sun, Li,&Li, Jun.(2018).Internalization of large particles by turbot (Scophthalmus maximus) IgM(+) B cells mainly depends on macropinocytosis.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,82,31-38.
MLA Li, Yi-qun,et al."Internalization of large particles by turbot (Scophthalmus maximus) IgM(+) B cells mainly depends on macropinocytosis".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 82(2018):31-38.
Files in This Item:
File Name/Size DocType Version Access License
Internalization of l(2306KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Yi-qun]'s Articles
[Sun, Li]'s Articles
[Li, Jun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Yi-qun]'s Articles
[Sun, Li]'s Articles
[Li, Jun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Yi-qun]'s Articles
[Sun, Li]'s Articles
[Li, Jun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.