Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Simpterpenoid A, a Meroterpenoid with a Highly Functionalized Cyclohexadiene Moiety Featuring gem-Propane-1,2-dione and Methylformate Groups, from the Mangrove-Derived Penicillium simplicissimum MA-332 | |
Li, Hong-Lei1![]() ![]() ![]() ![]() | |
2018-03-02 | |
Source Publication | ORGANIC LETTERS
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ISSN | 1523-7060 |
Volume | 20Issue:5Pages:1465-1468 |
Corresponding Author | Li, Xiao-Ming(lixmqdio@126.com) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
Abstract | Simpterpenoid A (1), an unprecedented meroterpenoid possessing a highly functionalized cyclohexadiene moiety (ring C) featuring gem-propane-1,2-dione and methylformate groups, was characterized from mangrove-derived Penicillium simplicissimum MA-332. Due to the highly oxygenated and functionalized ring C and lack of some key correlations, the unambiguous assignment of the planar structure and steric configuration was solved by X-ray crystallographic analysis. Compound 1 exhibited inhibitory activity against influenza neuraminidase in nanomolar quantities. |
DOI | 10.1021/acs.orglett.8b00327 |
Indexed By | SCI |
Language | 英语 |
Funding Project | Natural Science Foundation of China[31570356] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; Taishan Scholar Project from Shandong Province of China ; Natural Science Foundation of China[31570356] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; Taishan Scholar Project from Shandong Province of China |
WOS Research Area | Chemistry |
WOS Subject | Chemistry, Organic |
WOS ID | WOS:000426804200049 |
Publisher | AMER CHEMICAL SOC |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.qdio.ac.cn/handle/337002/158129 |
Collection | 实验海洋生物学重点实验室 |
Corresponding Author | Li, Xiao-Ming; Wang, Bin-Gui |
Affiliation | 1.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Inst Oceanol, Key Lab Expt Marine Biol,Lab Marine Biol & Biotec, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Heze Univ, Dept Life Sci, Daxue Rd 2269, Heze 274015, Peoples R China |
First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
Recommended Citation GB/T 7714 | Li, Hong-Lei,Xu, Rui,Li, Xiao-Ming,et al. Simpterpenoid A, a Meroterpenoid with a Highly Functionalized Cyclohexadiene Moiety Featuring gem-Propane-1,2-dione and Methylformate Groups, from the Mangrove-Derived Penicillium simplicissimum MA-332[J]. ORGANIC LETTERS,2018,20(5):1465-1468. |
APA | Li, Hong-Lei,Xu, Rui,Li, Xiao-Ming,Yang, Sui-Qun,Meng, Ling-Hong,&Wang, Bin-Gui.(2018).Simpterpenoid A, a Meroterpenoid with a Highly Functionalized Cyclohexadiene Moiety Featuring gem-Propane-1,2-dione and Methylformate Groups, from the Mangrove-Derived Penicillium simplicissimum MA-332.ORGANIC LETTERS,20(5),1465-1468. |
MLA | Li, Hong-Lei,et al."Simpterpenoid A, a Meroterpenoid with a Highly Functionalized Cyclohexadiene Moiety Featuring gem-Propane-1,2-dione and Methylformate Groups, from the Mangrove-Derived Penicillium simplicissimum MA-332".ORGANIC LETTERS 20.5(2018):1465-1468. |
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