Simpterpenoid A, a Meroterpenoid with a Highly Functionalized Cyclohexadiene Moiety Featuring gem-Propane-1,2-dione and Methylformate Groups, from the Mangrove-Derived Penicillium simplicissimum MA-332

doi:10.1021/acs.orglett.8b00327

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	Simpterpenoid A, a Meroterpenoid with a Highly Functionalized Cyclohexadiene Moiety Featuring gem-Propane-1,2-dione and Methylformate Groups, from the Mangrove-Derived Penicillium simplicissimum MA-332
	Li, Hong-Lei1 ; Xu, Rui1,2 ; Li, Xiao-Ming 1; Yang, Sui-Qun 1; Meng, Ling-Hong1 ; Wang, Bin-Gui1
	2018-03-02
Source Publication	ORGANIC LETTERS
ISSN	1523-7060
Volume	20 Issue:5 Pages:1465-1468
Corresponding Author	Li, Xiao-Ming(lixmqdio@126.com) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
Abstract	Simpterpenoid A (1), an unprecedented meroterpenoid possessing a highly functionalized cyclohexadiene moiety (ring C) featuring gem-propane-1,2-dione and methylformate groups, was characterized from mangrove-derived Penicillium simplicissimum MA-332. Due to the highly oxygenated and functionalized ring C and lack of some key correlations, the unambiguous assignment of the planar structure and steric configuration was solved by X-ray crystallographic analysis. Compound 1 exhibited inhibitory activity against influenza neuraminidase in nanomolar quantities.
DOI	10.1021/acs.orglett.8b00327
Indexed By	SCI
Language	英语
Funding Project	Natural Science Foundation of China[31570356] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; Taishan Scholar Project from Shandong Province of China
WOS Research Area	Chemistry
WOS Subject	Chemistry, Organic
WOS ID	WOS:000426804200049
Publisher	AMER CHEMICAL SOC
Citation statistics	Cited Times:12[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.qdio.ac.cn/handle/337002/158129
Collection	实验海洋生物学重点实验室
Corresponding Author	Li, Xiao-Ming; Wang, Bin-Gui
Affiliation	1.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Inst Oceanol, Key Lab Expt Marine Biol,Lab Marine Biol & Biotec, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Heze Univ, Dept Life Sci, Daxue Rd 2269, Heze 274015, Peoples R China
First Author Affilication	Institute of Oceanology, Chinese Academy of Sciences
Corresponding Author Affilication	Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation GB/T 7714	Li, Hong-Lei,Xu, Rui,Li, Xiao-Ming,et al. Simpterpenoid A, a Meroterpenoid with a Highly Functionalized Cyclohexadiene Moiety Featuring gem-Propane-1,2-dione and Methylformate Groups, from the Mangrove-Derived Penicillium simplicissimum MA-332[J]. ORGANIC LETTERS,2018,20(5):1465-1468.
APA	Li, Hong-Lei,Xu, Rui,Li, Xiao-Ming,Yang, Sui-Qun,Meng, Ling-Hong,&Wang, Bin-Gui.(2018).Simpterpenoid A, a Meroterpenoid with a Highly Functionalized Cyclohexadiene Moiety Featuring gem-Propane-1,2-dione and Methylformate Groups, from the Mangrove-Derived Penicillium simplicissimum MA-332.ORGANIC LETTERS,20(5),1465-1468.
MLA	Li, Hong-Lei,et al."Simpterpenoid A, a Meroterpenoid with a Highly Functionalized Cyclohexadiene Moiety Featuring gem-Propane-1,2-dione and Methylformate Groups, from the Mangrove-Derived Penicillium simplicissimum MA-332".ORGANIC LETTERS 20.5(2018):1465-1468.

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