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Comparative study of the effect of different fucoidans from Sargassum maclurei and Saccharina japonica on FGFs/FGFR signaling activation in BaF3 cells
Geng, Lihua1,2,3; Hou, Ningning1,2,3; Zhang, Meng4; Xu, Yingjie4; Zhang, Qi1,2,3; Wang, Jing1; Zhang, Lijuan4; Zhang, Quanbin1,3
2018-02-01
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
Volume107Pages:2429-2435
Corresponding AuthorZhang, Lijuan(zhanglj@qduhospital.cn) ; Zhang, Quanbin(qbzhang@qdio.ac.cn)
AbstractDifferent sulfated polysaccharides have distinct abilities to activate specific fibroblast growth factor (FGF) signaling pathways in FGFR1c-expressing BaF3 cells. In the current study, we first isolated and characterized different fucoidan fractions from Sargassum maclurei and Saccharina japonica. All of the fucoidan fractions were incubated with BaF3 cells in the presence of FGF-1, -2, -7, -8, -9, and -10, respectively, to evaluate their FGFs/FGFR1c signal-activating ability. Our data showed that low molecular weight fucoidan fraction from S. japonica with highest sulfate content (LMWF-2M) had the most potent activity among all of the six tested FGFs. Low sulfated heteropolysacchairde fraction LMWF-0.5M, along with SMP-1, SMP-D-1, and SMP-A-1, only activated the FGF-2/FGFR1c pair (P<0.05). In contrast, SMP, SMP-A, and SMP-D stimulated BaF3 cell proliferation except for FGF-8. Both LMWF-1M and LMWF-2M facilitated FGF-1-, -2-, -8-, and -9-based signaling. The sulfate content was the major contributing factor to the observed activity followed by the molecular weight. The monosaccharide composition also affected the activity, in that SMP and its derivatives with varied monosaccharide composition could not induce BaF3 cell proliferation in the presence of FGF-8. The structure-activity relationships revealed in current study provided useful information for the potential application of fucoidans in FGF/FGFR signaling regulation. (C) 2017 Published by Elsevier B.V.
KeywordFucoidan Sulfated polysaccharides Fibroblast growth factor (FGF) Fibroblast growth factor receptor (FGFR)
DOI10.1016/j.ijbiomac.2017.10.122
Indexed BySCI
Language英语
Funding ProjectSpecial Fund for Marine Scientific Research in the Public Interest[201405040] ; Natural Science Foundation of China[81672585] ; Key Technology Fund of Shandong Province[2016ZDJS07A07] ; Key Research and Development Project of Shandong Province[2016YYSP002] ; Key Research and Development Project of Shandong Province[2016GSF115031] ; Youth Innovation Promotion Association of CAS[2016190]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS IDWOS:000424062300117
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/158079
Collection实验海洋生物学重点实验室
Corresponding AuthorZhang, Lijuan; Zhang, Quanbin
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Qingdao Univ, Inst Cerebrovasc Dis, Affiliated Hosp, Qingdao 266003, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Geng, Lihua,Hou, Ningning,Zhang, Meng,et al. Comparative study of the effect of different fucoidans from Sargassum maclurei and Saccharina japonica on FGFs/FGFR signaling activation in BaF3 cells[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,107:2429-2435.
APA Geng, Lihua.,Hou, Ningning.,Zhang, Meng.,Xu, Yingjie.,Zhang, Qi.,...&Zhang, Quanbin.(2018).Comparative study of the effect of different fucoidans from Sargassum maclurei and Saccharina japonica on FGFs/FGFR signaling activation in BaF3 cells.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,107,2429-2435.
MLA Geng, Lihua,et al."Comparative study of the effect of different fucoidans from Sargassum maclurei and Saccharina japonica on FGFs/FGFR signaling activation in BaF3 cells".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 107(2018):2429-2435.
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