Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Integrated transcriptomic and proteomic analyses reveal potential mechanisms linking thermal stress and depressed disease resistance in the turbot Scophthalmus maximus | |
Yue, Xin1; Huan, Pin1; Hu, Yonghua1; Liu, Baozhong1,2
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| 2018-01-30 | |
| 发表期刊 | SCIENTIFIC REPORTS
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| ISSN | 2045-2322 |
| 卷号 | 8页码:13 |
| 通讯作者 | Liu, Baozhong(bzliu@qdio.ac.cn) |
| 摘要 | A worldwide increase in the reports of diseases affecting marine organisms has paralleled the climate warming over the past few decades. In this study, we applied omics to explore the mechanisms underlying thermo-linked epizootics, by comparing both the transcriptome- and proteome-wide response of turbots to a mimic pathogen (poly I:C) between high temperature and low temperature using a time-course approach. Our results showed that myeloperoxidase (MPO) and insulin were differentially expressed transcripts shared by all five time-points post poly I:C-injection between high and low temperature and also had a consistent expression trend as differentially expressed proteins at 24 h post injection. Combined with other data, it was suggested that the elevated temperature enhanced neutrophil-mediated immunity and the resultant MPO-mediated oxidative stress, which lasted for at least 5 days. The contents of malondialdehyde and protein carbonyls, markers of oxidative damage for lipids and proteins, respectively, were compared between different temperature groups, and the results further implied the emergence of oxidative damage under high temperature. It was also suggested that metabolism disorder likely occur considering the sustained expression changes of insulin. Hence, prolonged MPO-mediated oxidative stress and metabolic disorder might be involved in the thermo-linked epizootic. |
| DOI | 10.1038/s41598-018-20065-1 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Basic Research Program of China[2012CB114400] ; Scientific and Technological Innovation Project from Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02] ; National Basic Research Program of China[2012CB114400] ; Scientific and Technological Innovation Project from Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02] |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000423508900067 |
| 出版者 | NATURE PUBLISHING GROUP |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/157999 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Liu, Baozhong |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, 1 Wenhai Rd, Qingdao 266000, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 通讯作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Yue, Xin,Huan, Pin,Hu, Yonghua,et al. Integrated transcriptomic and proteomic analyses reveal potential mechanisms linking thermal stress and depressed disease resistance in the turbot Scophthalmus maximus[J]. SCIENTIFIC REPORTS,2018,8:13. |
| APA | Yue, Xin,Huan, Pin,Hu, Yonghua,&Liu, Baozhong.(2018).Integrated transcriptomic and proteomic analyses reveal potential mechanisms linking thermal stress and depressed disease resistance in the turbot Scophthalmus maximus.SCIENTIFIC REPORTS,8,13. |
| MLA | Yue, Xin,et al."Integrated transcriptomic and proteomic analyses reveal potential mechanisms linking thermal stress and depressed disease resistance in the turbot Scophthalmus maximus".SCIENTIFIC REPORTS 8(2018):13. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Integrated transcrip（1951KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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